Volume : 09, Issue : 10, October – 2022
28.FORMULATION DEVELOPMENT AND EVALUATION OF POLYHERBAL GEL OF EFFECTIVE TREATMENT OF ACNE
Anand bharatpure, Dr. Navjot Singh, Dr. Anwar Iqbal khan
The present research work deals with formulation and evaluation of herbal gels against this etiologic agent of acne vulgaris. Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. The crude extracts so obtained after the maceration process, each extracts were further concentrated on water bath evaporation the solvents completely to obtain the actual yield of extraction. To obtain the percentage yield of extraction is very important phenomenon in phytochemical extraction to evaluate the standard extraction efficiency for a particular plant, different parts of same plant or different solvents used. The extractive value of Embelia ribes, Acacia nilotica and Chenopodium album was found 6.98, 5.77, and 7.23% respectively. The prepared gel were evaluated for Psycho Rheological Characteristists, washability and Extrudability, spreadability, Determination of pH, Viscosity, and phenol content Formulations of gel the spreadibility ranging 9.25±2.10 to 13.25±1.25 the optimized formulation PHG4 is good (10.23±2.36). The formulation PHG4 has good viscosity 2545±11. The polyherbal gel obtained from plant used to suitably dilute upto the concentrations of 100, 50 and 25 microgram per ml and applied on to the test organism using well diffusion method.
Keywords: Viscosity, extrudability, rheology, drug content, extraction
Cite This Article:
Please cite this article in Anand bharatpure et al, Formulation Development And Evaluation Of Polyherbal Gel Of Effective Treatment Of Acne., Indo Am. J. P. Sci, 2022; 09(10).
1. Abel Nosereme Agbon, Helen Ochuko Kwaneshie and Wilson Oliver Hamman, Antidiarrheal Activity of Aqueous Fruit Extract of Phoenix dactylifera (Date Palm) in Wistar Rats, British Journal of Pharmacology and Toxicology 4(3): 121- 127, 2013.
2. Ansari Sufiyamohdazam Farhana, Antimicrobial and Synergistic Activity of Phoenix Dactylifera Seeds, Indian J.L.Sci. 4 (1) : 95-100, 2014.
3. Ayesha mateen, P.V.K. Suresh, Parwez Ahmed, Evaluation of antibacterial activity of cuscuta reflexa and abutilon indicum, international journal of pharma and bio sciences, 2011, (2) 4, pp. 355-361
4. Balakrishnan BR, Sangameswaran B, Bhaskar VH, Effect of methanol extract of Cuscuta reflexa aerial parts on hepatotoxicity induced by antitubercular drugs in rats, International Journal of Applied Research in Natural Products Vol. 3(1), pp. 18-22, March-April 2010
5. Bele A. A. Jadhav V M, Kadam V J. Formulation and evaluation of herbal drug. Drug invert today. 2010 2 (7) 369- 372.
6. Carl AB, Edward RA, David EB, Tietz NW, Text book of clinical chemistry and molecular diagnostics, 4th rev. ed., W.B Saunders Philadelphia, 2001.
7. Ch. Muhammad Tahir. Pathogenesis of Acne Vulgaris: Simplified. Journal of Pakistan Association of Dermatologists 2010; 20: 93-97.
8. Chukwugozie N Okwuosa, Theophilus K Udeani, Joshua E Umeifekwem, Augustine C Onuba, Innocent C Anioke1 and Romanus. E. Madubueze, Hepatoprotective Effect of Methanolic Fruit Extracts of Phoenix dactylifera (Arecaceae) on Thioacetamide Induced Liver Damage in Rats, American Journal of Phytomedicine and Clinical Therapeutics 2(3)2014 pp290-300.
9. Collected from Different Hosts, J Food Process Technol 2013, 4:5 pp 1-6.
10. Dandopani Chatterjee, Ram K Sahu, Arvind K Jha and Jaya Dwivedi, Evaluation of Antitumor Activity of Cuscuta Reflexa Roxb (Cuscutaceae) Against Ehrlich Ascites Carcinoma in Swiss Albino Mice, Tropical Journal of Pharmaceutical Research August 2011; 10 (4): 447-454.