Volume : 09, Issue : 10, October – 2022



Authors :

Mamatha Kola, SweythaVeeraganti, Vadnala Sravani

Abstract :

Transdermal drug delivery is an alternative route for systemic drug delivery which increases bioavailability and minimizes absorption. Orally ketoconazole (KTC) causes serious liver injury, increases dosing frequency, undergoes first pass hepatic and gastrointestinal metabolism. The purpose of this research work was to formulate and evaluate the matrix type of transdermal drug delivery system of ketoconazole. KTC patches were developed by using polymers HPMC (E15LV), Eudragit-L-100, PVP, Eudragit-S-100 by employing solvent casting method and reducing toxic effects. Oleic acid and Tween 80 were selected as permeation enhancer and PEG400 as plasticizer. F1-F9 formulations were prepared and evaluatedfor physicochemical characteristics (Thickness, flatness, uniformity of weight, moisture content, moisture loss, swelling index, folding endurance), drug content and in-vitro drug release studies. Based on the drug release and physicochemical values obtained, the formulation KTC4 showed a high percentage of drug release of 97.1% in 12 hr and was considered as an optimized formulation. FTIR and DSC studies indicated that there was no interaction between drug and excipients. From the present study it was concluded that KTC4 formulation followed zero order mechanism of drug release, promoting controlled release of the drug and successfully avoiding first pass hepatic and gastro intestinal metabolism.
Keywords: Solvent casting method, Ketoconazole (KTC), Permeation enhancer, Matrix transdermal patch and FTIR.

Cite This Article:

Please cite this article in Mamatha Kolaet al., Formulation And In-Vitro Evaluation Of Ketoconazole Patches For Transdermal Drug Delivery System., Indo Am. J. P. Sci, 2022; 09(10).


1.Balaji P, Thirumal M, Gowri R, Divya V, Ramaswamy V. Design and evaluation of matrix type of transdermal patches of methotrexate. Int J Pharm Chem Biol Sci. 2012; 2:464-71.
2. Lee VH. Controlled drug delivery: fundamentals and applications. CRC Press; 1987 Jan 30; 524-552.
3. Patel KN, Patel HK, Patel VA. Formulation and characterization of drug in adhesive transdermal patches of diclofenac acid. Int. J. Pharm. Pharm. Sci. 2012;4(1):296-9.
4. Chien YW. Novel drug delivery systems (Drugs and the pharmaceutical sciences). Transdermal Drug Delivery and Delivery Systems. 1992.
5. Aulton ME. Pharmaceutics. The science of dosage form design. 2002; 2;398-411
6. Allen L, Ansel HC. Ansel’s pharmaceutical dosage forms and drug delivery systems. Lippincott Williams & Wilkins; 2013 Dec 23;298-313.
7. Geeta Aggarwal and Sanju Dhawan Development, Fabrication and Evaluation of Transdermal Drug Delivery System – A Review, Pharmainfo.net, 2009.
8.Guy RH. Current status and future prospects of transdermal drug delivery. Pharm Res 1996; 13:1765-9
9.Patel HC, Parmar G, Seth AK, Patel JD, Patel SR. Formulation and evaluation of o/w nanoemulsion of ketoconazole. Pharm Sci Monit 2013; 4:338-51.
10. Ramzan M, Kaur G, Trehan S, Agrewala JN, Michniak-Kohn BB, Hussain A, Mahdi WA, Gulati JS, Kaur IP. Mechanistic evaluations of ketoconazole lipidic nanoparticles for improved efficacy enhanced topical penetration cellular uptake (L929 and J774A.1) and safety assessment: in vitro and in vivo studies. J Drug Deliv Sci Technol. 2021; 2:102743
11.Patel RR, Patel ZK, Patel KR, Patel MR. Formulation and evaluation of microemulsion based gel of ketoconazole. Int J Univers Pharm Bio Sci 2014;3:93-111.
12.Rajesh, N., Siddaramaiah, Gowda, D.V., Somashekar. C.N., Formulation and evaluation of biopolymer based transdermal drug delivery, Int. J. Pharmacy Pharm. Sci., 2010; 2, 142-147
13. Vijayan, V., Sumanth, M.H., Suman, L., vinay, T., Srinivasrao, D., Kumar. K.J., Development and physicochemical, in-vitro evaluation of Antihypertensive transdermal Patches. J. Pharm. Sci. & Res., 2010; 2(3), 171-177.
14.Shivaraj, A. Selvam, R.P., Mani, T.T., Sivakumar, T., Design and evaluation of transdermal drug delivery of ketotifen fumarate, Int. J. Pharm. Biomed. Res. 2010; 1(2), 42-47.
15.Ramkanth. S., Alagusundaram M., Gnanaprakash K., Rao K.M., Mohammed S.T.S., Paneer, K., Chetty M.C., Design and characterization of matrix type transdermal drug delivery System using metoprolol tartrate, Int. J. Pharm Res. 2010; 1 (1) 1-5.
16.Jufri M, Natalia M. Physical stability and antibacterial activity of black cumin oil (Nigella sativa L.) nanoemulsion gel. Int J PharmTech Res 2014;6:1162-9.
17. Derie DV, Burade KB, Kotwal RS, Galkwad VB. Formulation and evaluation of microemulsion based gel for topical delivery of ketoconazole. Indian Drugs 2008;45:138-40.
18. Rajesh N, Gowda D, Somasheka R. Formulation And Evaluation of Biopolymer Based Transdermal Drug Delivery. International Journal of Pharmacy & Pharmaceutical Sciences.2010; 2.
19. Mahanthesha.M.K., NagrajaT.S. and DR. Bharti,R.Yogendra, Desing and evaluation of Timolol maleate buccal patches using Tween as Permeation enhancer, Int. J. Uni. Phar. Bio.Sci, 2013, 2(3), 71.
20.Ubaidulla U., Reddy Molugu V.S., Ruckmani K., Ahmad Farhan J. and Khar Roop K Transdermal Therapeutic System of Carvedilol: Effect of Hydrophilic and Hydrophobic Matrix on In Vitro and In Vivo Characteristics. AAPS Pharm SciTech 2007, 81, E1-E8.