Volume : 09, Issue : 10, October – 2022



Authors :

K. Sadiya Samreen Sultana, I. Veena rani

Abstract :

Nephroprotective agents are material that has potential to minimize the effects of nephrotoxic agents. Medicinal plants have curative properties due to the presence of various complex chemical substances. Morinda citrifolia L (Noni) also known as Indian mulberry is a common plant known to grow in the tropical countries. The present study was focused on the investigation of Nephroprotective activity of the ethanolic extract of fruit Juice of Morinda citrifolia on cisplatin induced nephrotoxicity in Wistar albino rats. The phytochemical investigation revealed the presence of carbohydrate, alkaloids, flavanoids, glycosides, saponins, tannins, phenols and anthroquinone in EEMC. The administration of cisplatin during experimentation is effectively induced apoptosis and necrosis, which was similar to acute renal failure in human. Therefore, it is an effective and an ideal model for nephrotoxicity research. The evaluation of renal parameters on nephrotoxic rats with EEMC showed significantly elevate the attenuated body weight, urine volume, creatinine clearance and significantly reduce in elevated serum creatinine level, which supports its Nephroprotective activity.
Key words: Nephroprotective activity, Mornido citrofolia, Albino rats, phytochemical screenin

Cite This Article:

Please cite this article in press Veena rani et al, Evaluation Of Nephroprotective Activity Of Mornido Citrofolia In Albino Rats., Indo Am. J. P. Sci, 2022; 09(10).


1. S. Y. Kim and A. Moon, “Drug-induced nephrotoxicity and its biomarkers,” Biomolecules & erapeutics, vol. 20, no. 3, pp. 268–272, 2012.
2. K. Yapar, A. Kart, M. Karapehlivan et al., “Hepatoprotective efect of l-carnitine against acute acetaminophen toxicity in mice,” Experimental and Toxicologic Pathology, vol. 59, no. 2, pp. 121–128, 2007.
3. S. D. Nelson, “Mechanisms of the formation and disposition of reactive metabolites that can cause acute liver injury,” Drug Metabolism Reviews, vol. 27, no. 1-2, pp. 147–177, 1995. [4] U. A. Boelsterli, “Specifc targets of covalent drug-protein interactions in hepatocytes and their toxicological signifcance in drug-induced liver injury,” Drug Metabolism Reviews, vol. 25, no. 4, pp. 395–451, 1993.
4. J. L. Holtzman, “Te role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen,” Drug Metabolism Reviews, vol. 27, no. 1-2, pp. 277–297, 1995.
5. S. Palani, S. Raja, R. Praveen Kumar, S. Jayakumar, and B. Senthil Kumar, “Terapeutic efcacy of Pimpinella tirupatiensis (Apiaceae) on acetaminophen induced nephrotoxicity and oxidative stress in male albino rats,” International Journal of PharmTech Research, vol. 1, no. 3, pp. 925–934, 2009.
6. M. E. Placke, D. S. Wyand, and S. D. Cohan, “Extrahepatic lesions induced by acetaminophen in the mouse,” Toxicologic Pathology, vol. 15, no. 4, pp. 381–387, 1987.
7. L. Trumper, L. A. Monasterolo, and M. M. Elias, “Probenecid protects against in vitro acetaminophen-induced nephrotoxicity in male Wistar rats,” Journal of Pharmacology and Experimental erapeutics, vol. 283, pp. 606–610, 1998.
8. A. Ghosh and P. C. Sil, “Anti-oxidative efect of a protein from Cajanus indicus L. against acetaminophen-induced hepatonephro toxicity,” Biochemistry & Molecular Biology Journal, vol. 40, no. 6, pp. 1039–1049, 2007.
9. S. Palani, N. Kumar, R. Gokulan et al., “Evaluation of nephroprotective and antioxidant potential of Tragia involucrata,” Drug Discovery Today, vol. 1, no. 1, pp. 55–60, 2009.
10. S. D. Ray, V. R. Mumaw, R. R. Raje et al., “Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pre-treatment,” Journal of Pharmacology and Experimental erapeutics, vol. 279, pp. 1470– 1483, 1996.
11. P. A. Webster, D. W. Roberts, R. W. Benson, and G. L. Kearns, “Acetaminophen toxicity in children diagnostic confrmation using specifc antigen biomarker,” e Journal of Clinical Pharmacology, vol. 36, no. 5, pp. 397–402, 1996.
12. S. Palani, S. Raja, R. Naresh, and B. S. Kumar, “Evaluation of nephroprotective, diuretic and antioxidant activities of Plectranthus amboinicus on acetaminophen induced nephrotoxicity,” Informa Healthcare, vol. 20, no. 4, pp. 213–221, 2010.
13. R. C. Blantz, “Acetaminophen: Acute and chronic efects on renal function,” American Journal of Kidney Diseases, vol. 28, no. 1, pp. S3–S6, 1996.
14. P. Montilla, M. Barcos, M. C. Munoz, I. Bujalance, J. R. MunozCastaneda, and I. Tunez, “Red Wine Prevents Brain Oxidative Stress and Nephropathy in Streptozotocin-induced Diabetic Rats,” BMB Reports, vol. 38, no. 5, pp. 539–544, 2005.
15. R. Afroz, E. M. Tanvir, Md. F. Hossain et al., “Protective efect of sundarban honey against acetaminophen-induced acute hepatonephrotoxicity in rats,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 143782, 8 pages, 2014.
16. A. S. Abdel-Azeem, A. M. Hegazy, K. S. Ibrahim, A.-R. H. Farrag, and E. M. El-Sayed, “Hepatoprotective, antioxidant, and ameliorative efects of ginger (zingiber ofcinale roscoe) and vitamin e in acetaminophen treated rats,” Journal of Dietary Supplements, vol. 10, no. 3, pp. 195–209, 2013.
17. V. U. Ezeonwu and D. Dahiru, “Protective efect of biherbal formulation of Ocimum grasissimum and Gongronema latifolium aqueous leaf extracts on acetaminophen-induced hepato-nephrotoxicity in rats,” American Journal of Biochemistry, vol. 3, no. 1, pp. 18–23, 2013.
18. Z. Abdul Hamid, S. B. Budin, N. Wen Jie et al., “Nephroprotective of Zingier zerumbet smith ethyl acetate extract against paracetamol-induced nephrotoxicity and oxidative stress in rats,” Journal of Zhejiang University Science B, vol. 13, no. 3, pp. 176–185, 2012.
19. Parmar Sr., PH. Vashrambhai, and K. Kalia, “Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in rats,” Journal of Herbal Medicine and Toxicology, vol. 4, no. 2, pp. 101–106, 2010.
20. A. A. Adeneye and A. S. Benebo, “Protective efect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced neprotoxic rats,” Journal of Ethnopharmacology, vol. 118, no. 2, pp. 318–323, 2008.
21. K. Gaikwad, P. Dagle, P. Choughule et al., “A review on some nephroprotective medicinal plants,” International Journal of Pharmaceutical Sciences and Research, vol. 3, no. 8, pp. 2451– 2454, 2012.
22. AK. Rad, R. Mohebbati, and S. Hosseinian, “Drug-induced nephrotoxicity and medicinal plants,” Iranian Journal of Kidney Diseases, vol. 11, pp. 169–179, 2017.
23. Q. Zaid Ahmad, Herbs as nephroprotective agent: an over view with reference to unani system of medicine, vol. 1, Austin Publishing Group, 1 edition, 2016.
24. E. Yarnell and K. Abascal, “Herbs for relieving chronic renal failure,” Alternative and Complementary erapies, vol. 13, no. 1, pp. 18–23, 2007. [26] S. M. Talbott, J. A. Talbott, A. George, and M. Pugh, “Efect of Tongkat Ali on stress hormones and psychological mood state in moderately stressed subjects,” Journal of the International Society of Sports Nutrition, vol. 10, article no 28, 2013.
25. Ying WM, West BJ, Jensen CJ, Nowicki D, Chen SU, Paul AK, et al. Morinda citrofolia (Noni): A literature review and recent advances in noni research. Acta Pharmacol Sin. 2002;23(12):1127-41.
26. Wang MY, Nowicki D, Anderson G, Jenson J, West B. Liver protective effects of Morinda citrifolia (Noni). Plant Foods Hum Nutr. 2008;63:59–63.
27. McClatchey W. From Polynesian healers to health food stores: Changing perspectives of Morinda citrifolia (Rubiaceae). Integr Cancer Ther. 2002;1(2): 110-20.
28. Mckoy MG, Thomas EA, Simon OR, Preliminary investigations of anti-inflammatory properties of an aqueous extract from Morinda citrifolia (Noni). Proc West Pharmacol Soc. 2002;45:76-78.
29. Ma D, West BJ, Su CX, Gao J, Liu T, Liu YW. Evaluation of ergogenic potential of noni juice. Photother Res. 2007;21:1100-01.