Volume : 09, Issue : 10, October – 2022

Title:

45.EVALUATION OF ANTI HYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF AMARANTHUS ROXBHURGIANUS IN ALBINNO RATS

Authors :

Saniya Sadaf, I. Veena rani

Abstract :

Hyperlipidemia is a disorder of lipid metabolism manifested by increase of plasma concentrations of the various lipid and lipoprotein fractions such as increase of serum total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG) concentrations, and a decrease in the high-density lipoprotein (HDL) concentration. The aim of the present study is to promote a potential new herbal formulation to prevent atherosclerosis at a low cost. In this study ethanolic extract of Amaranthus roxbhurgianus- showed positive to following phytochemical constituent’s Carbohydrates, Glycosides, Flavonoids, Proteins, Sterols. The significant reduction in serum cholesterol,TG,LDL, ,AI, and also increased in total HDL level in the different dose level(100,200 mg/kg) in high cholesterol diet. Hence it is going to be concluded that the potential benefits of the extracts of Amaranthus roxbhurgianus has been demonstrated well in advance and can be used further to demonstrate the antihyperlipidemic as well as controlling of both triglyceride levels and reducing the risk of factors of cholesterol inducers. The aforementioned results of the research suggest that the Amaranthus roxbhurgianus found to have the potential antihyperlipidemic action.
Keywords: Anti-hyperlipidemic activity, Amaranthus Roxbhurgianus, Albino rats

Cite This Article:

Please cite this article in press I. Veena rani et al, Evaluation Of Anti Hyperlipidemic Activity Of Ethanolic Extract Of Amaranthus Roxbhurgianus In Albinno Rats., Indo Am. J. P. Sci, 2022; 09(10).

References:

1. Ansarullah, Jadeja RN, Thounaojam MC, Patel V, Devkar RV, Ramachandran AV. Antihyperlipidemic potential of a polyherbal preparation on triton WR 1339 (Tyloxapol) induced hyperlipidemia: A comparison with lovastatin. Int J Green Pharm. 2009;3:119–24
2. Ghule BV, Ghante MH, Saoji AN, Yeole PG. Hypolipidemic and antihyperlipidemic effects of Lagenariasiceraria (Mol.) fruit extracts. Indian J Exp Biol. 2006;44:905–
a. 9. [PubMed] [Google Scholar]
3. Nomura H, Kimura Y, Okamoto O, Shiraishi G. Effects of antihyperlipidemic drugs and diet plus exercise therapy in the treatment of patients with moderate Hypercholesterolemia. Clin Ther. 1996;18:196. [PubMed] [Google Scholar]
4. Ajzen I. The theory of planned behavior reactions and reflections. Health Psychology Review. 1991; 5:97-144.
5. Alimi, Ajewole, Olubode A, Idowu EO. Organic and inorganic fertilizer for vegetable production under tropical conditions. Journal of agricultural and rural development. 2007; (1): 120-136.
6. Rang HP, Dale MM, Ritter JM, Flower RJ. Rang and dale’s Pharmacology. 6th ed. London: Publisher: Elsevier;2007.p.323-327.
7. Sankara Rao, K., Raja K Swamy, Deepak Kumar, Arun Singh R. and K. Gopalakrishna Bhat (2019). Flora of Peninsular India. http://peninsula.ces.iisc.ac.in/plants.php?name=Amaranthus roxburghianus. Downloaded on 6 November 2022.
8. Swapnil SA, Anup BT, Shukla VJ, Ashok BK, Ravishankar B. Evaluation of anti-hyperlipidemic activity of Lekhana Basti in albino rats. Ayu. 2013 Apr;34(2):220-5
9. 32. Olaiya CO, Omolekan TO. Antihypercholesterolemic activity of ethanolic extract of Buchholzia coriacea in rats. Afr Health Sci. 2013 Dec;13(4):1084-90.
10. Kadam, P., Chaware, V., & Redasani, V. (2021). Evaluation of Anti-hyperlipidemic Activity of Red Onion In Experimental Animals. Asian Journal of Pharmaceutical Research and Development, 9(4), 52-62.
11. Dinesh Dhingra,Deepak Lamba,1Ramesh Kumar,2Pashupati Nath,2and Satyaprakash Gauttam. Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase. International Scholarly Research Notices.2014
12. B.V.S. Lakshmi, N.Neelima, N.Kasthuri, V.Umarani, M. Sudhakar. Antihyperlipidemic activity of Bauhinia purpurea extracts in hypercholesterolemic albino rats. International Journal of PharmTech Research.2011,3(3),1265-1272
13. Rohit Gundamaraju, Kim Kah Hwi, Rajeev K Singla, Ravi Chandra Vemuri, and Sartaj Banu Mulapalli. Antihyperlipidemic Potential of Albizia amara (Roxb) Boiv. Bark Against Triton X-100 Induced Hyperlipidemic Condition in Rats. Pharmacognosy research, vol 6, issue 4, oct-dec, 2014