Volume : 09, Issue : 10, October – 2022

Title:

46.EVALUATION OF ANALGESIC AND ANTIINFLAMMATORY EFFECTS OF ETHANOLIC LEAVES EXTRACT OF AMARANTHUS ROXBURGHIANUS
‬

Authors :

Mukkagalla Vandana, I. Veena rani

Abstract :

Amaranthus roxburghianus is one of the traditionally well-known plants with outstanding therapeutic properties, and is used mostly in treating different diseases in India. Thus, based on these medicinal properties, various investigations have been undertaken in order to appraise the pharmacological activities and the chemical composition of these species. Here, we elucidate the analgesic and anti-inflammatory activity of Amaranthus roxburghianus ethanolic leaves extract. phytochemical screening of Amaranthus roxburghianus extract showed the presence of alkaloids, Carbohydrates, Glycosides, Flavonoids, Tannins, Proteins, Amino Acids. the ethanolic leaves extract of Amaranthus roxburghianus, possess peripheral and central analgesic activity in animal model. The Amaranthus roxburghianus leaves extract shows anti-inflammatory activity in different animal model. Flavonoids and tannins are the major constituents of Amaranthus roxburghianus leaves, which may be responsible for its Analgesic, Anti-inflammatory activity.
KEYWORDS: Amaranthus roxburghianus, Phytochemical screening, Analgesic activity, Anti-inflammatory activity

Cite This Article:

References:

1. Tousoulis D, Davies G, Stefanadis C, Toutouzas P, Ambrose JA. Inflammatory and thrombotic mechanisms in coronary atherosclerosis. Heart. 2003;89(9):993–997.
2. Rus H, Niculescu FI. Inflammation, aspirin, and the risk of cardiovascular disease. The New England Journal of Medicine. 1997;337(6):p. 422. author reply 423-424.
3. Ferreira SH. Peripheral analgesia: mechanism of the analgesic action of aspirin like drugs and opiate-antagonists. British Journal of Clinical Pharmacology. 1980;10(supplement 2):237S–45S.
4. Hajhashemi V, Ghannadi A, Pezeshkian SK. Antinociceptive and anti-inflammatory effects of Satureja hortensis L. extracts and essential oil . Journal of Ethnopharmacology. 2002;82(2-3):83–87.
5. Chakrabarti R, Damarla RK, Mullangi R, Sharma VM, Vikramadithyan RK, Rajagopalan R. Insulin sensitizing property of Amaranthus roxburghianus extract. J Ethnopharmacol 2006; 105:102-6.
6. Chetty KM, Sivaji K, Rao KT. Flowering Plants of Chittoor District Andhra Pradesh, India. Tirupati: Student Offset Printers; 2008.
7. Khandelwal K R, Practical Pharmacognosy— Techniques and Experiments, Nirali Prakashan, 9th edition, 2002.
8. Kokate C K, Purohit A P, and Gokgale S B, Pharmacognosy, Nirali Prakashan, 4th edition, 2002.
9. Khan H, Saeed M, Gilani AUH, Khan MA, Dar A, Khan I: The antinociceptive activity of Polygonatumverticillatum rhizomes in pain models. J Ethnopharmacol. 2010, 127 (2): 521-527.
10. 10.Brochet D, Micó JA, Martin P, Simon P: Antinociceptive activity of beta-adrenoceptor agonists in the hot plate test in mice. Psychopharmacol. 1986, 88 (4): 527-528.
11. 11.Singh S, Majumdar D, Rehan H: Evaluation of anti-inflammatory potential of fixed oil of Ocimum sanctum (Holybasil) and its possible mechanism of action. J Ethnopharmacol. 1996, 54 (1): 19-26.
12. 12.J.P. Dzoyem, L.J. McGaw, V. Kuete, U. Bakowsky, Chapter 9 – Anti-inflammatory and Anti-nociceptive Activities of African Medicinal Spices and Vegetables,Editor(s): Victor Kuete,Medicinal Spices and Vegetables from Africa,Academic Press, 2017, 239-270,