Volume : 09, Issue : 10, October – 2022
54.DESIGN AND DEVELOPMENT OF TRIMETAZIDINE HYDROCHLORIDE SUSTAINED RELEASE MICROSPHERES
Vadla saipreethi, Dr Alladi Saritha
The meaning of microencapsulation is converting liquids to solids, altering colloidal and surface properties, providing environmental protection and controlling the release characteristics by using the coating materials. Trimetazidine is indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies. Aim of the study is to formulate Trimetazidine hydrochloride double walled microspheres using different polymers by solvent evaporation method. In the present work, twofold walled microspheres of Trimetazidine hydrochloride utilizing Sodium alginate alongside Carbopol 934 and HPMC K100, Guar gum as copolymers were planned to convey Trimetazidine hydrochloride by means of oral course. Among all plans F7 shows Maximum medication discharge in 12hrs when contrasted and different details. Examination of medication discharge system showed that the medication discharge from the definitions followed the Non fickian dissemination instrument and follows zero request kinectics. In light of the consequences of assessment tests definition coded F7 was closed as best plan.
Key words: Trimetazidine hydrochloride, Sustained release microspheres, Formulation, Evaluation.
Cite This Article:
Please cite this article in press Alladi Saritha et al, Design And Development Of Trimetazidine Hydrochloride Sustained Release Microspheres., Indo Am. J. P. Sci, 2022; 09(10).
1. Jayakrishnan A, Latha MS. Biodegradable polymeric microspheres as drug carriers. In: Jain NK, Editor. Controlled and Novel drug delivery. New Delhi: CBS publishers. 1997. pp 236-255.
2. Vyas SP, Khar RK. Proteins and peptides delivery considerations. In: Vyas SP, Khar RK, Editor. Controlled drug delivery concepts and advances. 1st ed. New Delhi: CBS publisher and Distributor. 2002; pp 549.
3. Fu, X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behavior in vitro of huperzine A-PLGA microspheres. J Microencap 2005; 22(7): 705-714.
4. Jalil R, Nixon JR. Biodegradable poly(lactic acid) and poly(lactide-co-glycocide) microcapsules: problems associated with preparative techniques and release properties. J Microencap 1990b; 7: 297–325.
5. Kawaguchi H. Functional polymer microspheres. Prog Polym Sci 2000; 25: 1171–1210.
6. Mueller RH, Jacobs C, Kayser O. Nanosuspensions as particulate drug formulations in therapy rationale for development and what we can expect for the future. Adv Drug Deliv Review 2001; 47: 3–19.
7. Edlund U, Albertsson AC. Degradable polymer microspheres for controlled drug delivery. Adv Polymeric Science 2002; 157: 67–112.
8. Vasir JK, Tambwekar K, Garg GS. Bioadhesive microspheres as a controlled drug delivery system. Int J Pharm 2003; 255: 13–32.
9. O’Donnell PB, McGinity JW. Preparation of microspheres by the solvent evaporatin technique. Adv Drug Deliv Reviews 1997; 28: 25-42.
10. Leelarasamee N, Howard SA, Malanga CJ, Ma JKH. A method for the preparation of poly(lactic acid) microcapsules of controlled particle size and drug loading. J Microencap 1988; 52: 147-157.
11. Bain DF, Munday DL, Smith A. Solvent influence on spray dried biodegradable microspheres. J Microencap 1999; 16: 453-474.
12. Trimetazidine is indicated for the symptomatic treatment of stable angina pectoris in patients inadequately controlled or intolerant to first line therapies.
13. MacInnes A, Fairman DA, Binding P, Rhodes Ja, Wyatt MJ, Phelan A, Haddock PS, Karran EH: The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circ Res. 2003 Aug 8;93(3):e26-32. doi: 10.1161/01.RES.0000086943.72932.71. Epub 2003 Jul 17. (PubMed ID 12869391)