Volume : 09, Issue : 10, October – 2022

Title:

73.PREDICTION OF DRUG-DRUG INTERACTION POTENTIAL NANOSPONGES: A NOVEL CLASS OF DRUG DELIVERY SYSTEM AND ITS APPLICATIONS
‬

Authors :

Ranjith kumar.S, Anto.A , Vigneshwaran L.V, Senthil Kumar.M ⃰

Abstract :

Small, mesh-like structures called nanosponges have a size range of less than 1 m. They can readily bind poorly soluble pharmaceuticals because of their small size and porous structure, which improves the solubility and, in turn, the bioavailability of the same drugs.Both lipophilic and hydrophilic drugs can be loaded into nanosponges. Nanosponges play a major role in targeting drug delivery systems. These can move through the body until they come into contact with the intended target spot, where they adhere to the surface and start to release the medicine in a regulated and predictable manner.The application of nanosponges, its preparation processes, and assessment criteria have been covered in this review article. Nanosponges are solid by nature and can be produced as oral, parenteral, topical, or inhalation dosage forms.
Keywords: Nanosponge , Drug delivery , Therapeutic applications.

Cite This Article:

References:

1. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Valero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges. EP 1 786 841 B1; 2007.
2. David F. Nanosponge drug delivery systems are more effective than direct injection. www.physorg.com 01.06.2010, accessed on 20.12.2011.
3. Trotta F, Tumiatti V, Cavalli R, Rogero C, Mognetti B, Berta G. Cyclodextrin-based nanosponges as a vehicle for Antitumoral drugs. WO 2009/003656 A1; 2009.
4. Jenny A, Merima P, Alberto F, Francesco T. Role of β- cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86: 127– 135.
5. Renuka S, Roderick BW, Kamla P. Evaluation of the kinetics and mechanism of drug release from Econazole Nitrate nanosponge loaded carbopol hydrogel. Ind J Pharm Edu Res, 2011; 45(1): 25-31.
6. Renuka S, Kamla P. Polymeric nanosponges as an alternative carrier for improved retention of
econazole nitrate onto the skin through topical hydrogel formulation Pharm Dev Technol. 2011; 16(4):367-376.
7.18. Gilardi G, Trota F, Cavalli R, Ferruti P, Ranucci E, Di Nardo G, Roggero C, Tumiatti V. Cyclodextrin nanosponges as carriers for biocatalysts, and in the delivery and release of enzymes, proteins, vaccines and antibodies. WO2009149883 A1; 2009.
8.Divya Singh , G.C. Soni, S.K. Prajapati. Recent Advances inNanosponges as Drug Delivery
System: A Review Article.EurJPharmaceut and Med Res.2016; 3(10): 364-371.
9.Balasaheb Murlidhar Targe, Moreshwar P. Patil, Amol C. Jahagirdar, Baliram D. Khandekar.Nanosponges – An Emerging Drug Delivery System.Int J Inst Pharm and Life Sci.2015:5(6).
10. Swaminathan S, Pastero L, Serpe L, Trotta F, Vavia P, Aquilano D et al. (2010). Cyclodextrin-based nanosponges encapsulating camptothecin: physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm, 74:193–201.
11. Castiglione V, Crupi D, Majolino D, Mele A, Panzeri W. et al. Vibrational dynamics and hydrogen bond properties of β-CD nanosponges: an FTIR-ATR, Raman and solid-state NMR spectroscopic study. J Incl Phenom Macrocycl Chem. 2012; doi 10.1007/s10847-012-0106-z
12. Dhavala PB, Kumar VS. An Interesting Nanosponges as a Nanocarrier for Novel drug delivery: A Review, Int J of Pharm and Med Res. 2017; 5(2)
13. Khan KA, Bhargav E, Reddy KR, Sowmya C. Nanosponges: A New Approach for Drug Targeting. Int. J pharm. pharm. res. 2016; 7(3):381-396.
14. Subramanian S, Singireddy A, Krishnamoorthy K, Rajappan M. A Novel Class of Drug Delivery System-Review. J Pharm Pharm Sci. 2012; 15(1):103-111.
15. Singh A. Development and Evaluation of Cyclodextrin Based Nanosponges for Bioavailability Enhancement of Poorly Bioavailable Drug. World J. Pharm Pharm Sci. 2017; 6(2):805-836.
16. Jenny A, Merima P, Alberto F, Francesco T. Role of β- cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86: 127– 135.
17. . Lala R, Thorat A, Gargote C. Current trends in β-cyclodextrin based drug delivery systems. Int J Res Ayur Pharm, 2011; 2(5): 1520-1526.
18. Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z,
Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm, 2010; 74: 193-201.