Volume : 09, Issue : 10, October – 2022



Authors :

Anwar khan, Nimbra Ishfaq

Abstract :

Idiopathic granulomatous mastitis, a breast disease which often occurs in women. Some studies and according to the media sources it is obtained that the treatment of this disease is always in trouble. In some studies, it is obtained that with the proper treatment of doctor and through some medicines this disease can be cured affectionately.
Total above eighty women participated in this study, the data is obtained from different hospitals in Pakistan. After the cure, the result is obtained that through the proper method how many women were cured completely and how much percentage that this disease come back to the patient again.
A total of eighty-five women participated in this study. The age of women is from twenty-three to fifty-four. All the patients suffering from this disease above fifty percent of patients have pain in the breast. And above fifty-five percent of the patient suffer from swelling and above four percent of a patient have another disease. The total duration of monitoring the patients is from nine to fifty months after the cure ness or before the cure. Above thirty percent patients undergoing surgery and above thirty percent of patients give high range of dose and low dose with the drainage given to fifteen percent of patients.
In this study, three methods are used to cure breast disease, first one is the high dose, second one is the low dose with drainage and third is the surgery. In this study, we conclude that the method named low dose along with the drainage is a more effective method and perfect method. This method has side effects but this method is effective as compared to other two methods.
Keywords: Surgery, Drainage, Analysis, Idiopathic.

Cite This Article:

Please cite this article in press Anwar khan et al, Idiopathic Granulomatous Mastitis, A Breast Disease, Occurs In Women, Study Of Trouble Of Treatment Of This Disease In Chinese Women., Indo Am. J. P. Sci, 2022; 09(10).


1. Kessler E, Wolloch Y. Granulomatous mastitis: a lesion clinically simulating carcinoma. Am J Clin Pathol. 1972;58(6):642-6. doi: 10.1093/ajcp/58.6.642.
2. Martinez-Ramos D, Simon-Monterde L, Suelves-Piqueres C, Queralt-Martin R, Granel-Villach L, Laguna-Sastre JM, et al. Idiopathic granulomatous mastitis: A systematic review of 3060 patients. Breast J. 2019;25(6):1245-50. doi: 10.1111/tbj.13446.
3. Metanat S, Jobaneh YS, Noori M, Sadeghi F, Mirzapour A, Mashoori N, et al. Global Distribution of Idiopathic Granulomatous Mastitis: A Scoping Review: IGM Global Distribution. Archives of Breast Cancer. 2022;9(special Issue).
4. Azlina AF, Ariza Z, Arni T, Hisham AN. Chronic granulomatous mastitis: diagnostic and therapeutic considerations. World journal of surgery. 2003;27(5):515-8. doi:10.1007/S00268-003-6806-1
5. Tamura Y. Granulomatous Mastitis with Corynebacterium Infection: IGM with Corynebacterium. Archives of Breast Cancer. 2022;9(special Issue).
6. Lei X, Chen K, Zhu L, Song E, Su F, Li S. Treatments for Idiopathic Granulomatous Mastitis: Systematic Review and Meta-Analysis. Breastfeed Med. 2017;12(7):415-21. doi: 10.1089/bfm.2017.0030.
7. Gunduz Y, Altintoprak F, Tatli Ayhan L, Kivilcim T, Celebi F. Effect of topical steroid treatment on idiopathic granulomatous mastitis: clinical and radiologic evaluation. The breast journal. 2014;20(6):586-91. doi: 10.1111/TBJ.12335.
8. Tekgöz E, Çolak S, Çinar M, Yilmaz S. Treatment of idiopathic granulomatous mastitis and factors related with disease recurrence. Turkish Journal of Medical Sciences. 2020;50(5):1380-. doi: 10.3906/SAG-2003-93.
9. Karanlik H, Ozgur I, Simsek S, Fathalizadeh A, Tukenmez M, Sahin D, et al. Can Steroids plus Surgery Become a First-Line Treatment of Idiopathic Granulomatous Mastitis? Breast care (Basel, Switzerland). 2014;9(5):338-42. doi: 10.1159/000366437.
10. Pandey TS, MacKinnon JC, Bressler L, Millar A, Marcus EE, Ganschow PS. Idiopathic granulomatous mastitis–a prospective study of 49 women and treatment outcomes with steroid therapy. The breast journal. 2014;20(3):258-66. doi: 10.1111/TBJ.12263.
11. Curtis JR, Westfall AO, Allison J, Bijlsma JW, Freeman A, George V, et al. Population-based assessment of adverse events associated with long-term glucocorticoid use. Arthritis Rheum. 2006;55(3):420-6. doi: 10.1002/art.21984.
12. Waljee AK, Rogers MA, Lin P, Singal AG, Stein JD, Marks RM, et al. Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study. Bmj. 2017;357:j1415. doi: 10.1136/bmj.j1415.
13. Aghajanzadeh M, Hassanzadeh R, Alizadeh Sefat S, Alavi A, Hemmati H, Esmaeili Delshad MS, et al. Granulomatous mastitis: Presentations, diagnosis, treatment and outcome in 206 patients from the north of Iran. Breast (Edinburgh, Scotland). 2015;24(4):456-60. doi: 10.1016/J.BREAST.2015.04.003.
14. Akcan A, Öz AB, Dogan S, Akgün H, Akyüz M, Ok E, et al. Idiopathic Granulomatous Mastitis: Comparison of Wide Local Excision with or without Corticosteroid Therapy. Breast care (Basel, Switzerland). 2014;9(2):111-5. doi: 10.1159/000360926.
15. Akin M, Karabacak H, Esendağli G, Yavuz A, Gültekin S, Dikmen K, et al. Coexistence of idiopathic granulomatous mastitis and erythemanodosum: successful treatment with corticosteroids. Turkish journal of medical sciences. 2017;47(5):1590-2. doi: 10.3906/SAG-1611-100.
16. Altintoprak F. Topical steroids to treat granulomatous mastitis: a case report. The Korean journal of internal medicine. 2011;26(3):356-9. doi: 10.3904/KJIM.2011.26.3.356
17. Alungal J, Abdulla MC, Narayan R. Idiopathic granulomatous mastitis with erythema nodosum and polyarthritis. Reumatismo. 2016;68(2):97-9. doi: 10.4081/REUMATISMO.2016.844.
18. Atak T, Sagiroglu J, Eren T, Özemir IA, Alimoglu O. Strategies to treat idiopathic granulomatous mastitis: retrospective analysis of 40 patients. Breast disease. 2015;35(1):19-24. doi: 10.3233/BD-140373.
19. Berkesoglu M, Dag A, Tuncel F, Ustun RO. Management of Granulomatous Mastitis Following Aesthetic Breast Surgery. Aesthetic plastic surgery. 2021;45(3):875-81. doi: 10.1007/S00266-020-01992-9.
20. Binesh F, Shiryazdi M, Owlia MB, Azimi S. Idiopathic granulomatous mastitis, erythema nodosum and bilateral ankle arthritis in an Iranian woman. BMJ case reports. 2013;2013. doi: 10.1136/BCR-2012-007636.
21. Nguyen MH, Molland JG, Kennedy S, Gray TJ, Limaye S. Idiopathic granulomatous mastitis: case series and clinical review. Intern Med J. 2021;51(11):1791-7. doi: 10.1111/imj.15112.
22. Al Manasra ARA, Al-Hurani MF. Granulomatous Mastitis: A Rare Cause of Male Breast Lump. Case Reports in Oncology. 2016;9(2):516-9. doi: 10.1159/000448990.
23. Barreto DS, Sedgwick EL, Nagi CS, Benveniste AP. Granulomatous mastitis: etiology, imaging, pathology, treatment, and clinical findings. Breast Cancer Research and Treatment. 2018;171(3):527-34. doi: 10.1007/s10549-018-4870-3.
24. Benson JR, Dumitru D. Idiopathic granulomatous mastitis: presentation, investigation and management. Future Oncol. 2016;12(11):1381-94. doi: 10.2217/fon-2015-0038.
25. V S, R K, Murthy VS. Multinucleate Giant Cells in FNAC of Benign Breast Lesions: Its Significance. Journal of clinical and diagnostic research : JCDR. 2014;8(12):Fc01-4. doi: 10.7860/JCDR/2014/9654.5256.
26. Pala EE, Ekmekci S, Kilic M, Dursun A, Colakoglu G, Karaali C, et al. Granulomatous Mastitis: A Clinical and Diagnostic Dilemma. Turk Patoloji Derg. 2022;38(1):40-5. doi: 10.5146/tjpath.2021.01554.
27. Tse GM, Poon CS, Ramachandram K, Ma TK, Pang LM, Law BK, et al. Granulomatous mastitis: a clinicopathological review of 26 cases. Pathology. 2004;36(3):254-7. doi: 10.1080/00313020410001692602.
28. Helal TE, Shash LS, Saad El-Din SA, Saber SM. Idiopathic Granulomatous Mastitis: Cytologic and Histologic Study of 65 Egyptian Patients. Acta cytologica. 2016;60(5):438-44. doi: 10.1159/000448800.
29. D’Alfonso TM, Moo TA, Arleo EK, Cheng E, Antonio LB, Hoda SA. Cystic Neutrophilic Granulomatous Mastitis: Further Characterization of a Distinctive Histopathologic Entity Not Always Demonstrably Attributable to Corynebacterium Infection. The American journal of surgical pathology. 2015;39(10):1440-7. doi: 10.1097/PAS.0000000000000479.
30. Gautham I, Radford DM, Kovacs CS, Calhoun BC, Procop GW, Shepardson LB, et al. Cystic neutrophilic granulomatous mastitis: The Cleveland Clinic experience with diagnosis and management. The breast journal. 2019;25(1):80-5. doi: 10.1111/tbj.13160.
31. Johnstone KJ, Robson J, Cherian SG, Wan Sai Cheong J, Kerr K, Bligh JF. Cystic neutrophilic granulomatous mastitis associated with Corynebacterium including Corynebacterium kroppenstedtii. Pathology. 2017;49(4):405-12. doi: 10.1016/j.pathol.2017.01.006.
32. Naik MA, Korlimarla A, Shetty ST, Fernandes AM, Pai SA. Cystic Neutrophilic Granulomatous Mastitis: A Clinicopathological Study With 16s rRNA Sequencing for the Detection of Corynebacteria in Formalin-Fixed Paraffin-Embedded Tissue. International journal of surgical pathology. 2020;28(4):371-81. doi: 10.1177/1066896919896021.
33. Wu JM, Turashvili G. Cystic neutrophilic granulomatous mastitis: an update. Journal of clinical pathology. 2020;73(8):445-53. doi: 10.1136/jclinpath-2019-206180.
34. Patel A, Sung S, Hoda SA, Westblade LF, D’Alfonso T, Rao R. Cytomorphological features of cystic neutrophilic granulomatous mastitis on ThinPrep. Diagnostic cytopathology. 2018;46(11):966-70. doi: 10.1002/dc.23988.
35. Li XQ, Wu HL, Yuan JP, Liu TG, Sun SR, Chen C. Bacteria Associated with Granulomatous Lobular Mastitis and the Potential for Personalized Therapy. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2022;35(1):164-70. doi: 10.1080/08941939.2020.1833262.
36. Li XQ, Yuan JP, Fu AS, Wu HL, Liu R, Liu TG, et al. New Insights of Corynebacterium kroppenstedtii in Granulomatous Lobular Mastitis based on Nanopore Sequencing. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2022;35(3):639-46. doi: 10.1080/08941939.2021.1921082.