Volume : 09, Issue : 09, September – 2022
10.FORMULATION AND EVALUATION OF CONTROLLED DRUG DELIVERY SYSTEM CONTAINING ACARBOSE
Tripathi Sanskrit, Patel Arun, Patel Shailendra
Oral controlled drug delivery systems refer to those products where in a release controlling technology is instigated which in turn modulates the release pattern of drug from the device into gastro intestinal tract. The tablets are coated with cellulose acetate polymer contain polyethylene glycol 400 and polyvinyl pyrrolidine K30 (20 %) as pore former in varying concentration, which is dissolved in acetone (60 %) solution. In EOP the delivery orifice had been drilled on the surface of the coated tablet by mechanical method. The stability determination recommended by ICH guidelines testing parameters were carried with designed formulation for the 12-month study reveals, the osmotic tablets were stable under the standard operational conditions. The post compression parameter like thickness, hardness, uniform drug content, in vitro release kinetics and average weight of tablets are comparable with standard reference of Acarbose. The in vitro release data of optimized formulation CP5 determined by USP type II dissolution apparatus shows 96.6 ± 0.15 % at 12 hr. The kinetic modelling of release data gives the information of release mechanism from osmotic pump was mainly by diffusion and osmosis.
Cite This Article:
Please cite this article in press Tripathi Sanskrit et al, Formulation And Evaluation Of Controlled Drug Delivery System Containing Acarbose., Indo Am. J. P. Sci, 2022; 09(9).
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