Volume : 09, Issue : 09, September – 2022

Title:

29.EVALUATION OF ANTI –INFLAMATORY AND ANALGESIC ACTIVITY OF PAINOFF BY FOLLOWING ANIMAL MODELS

Authors :

K. Sivaji, B. Harika, Y. Surya Chandra Mani, P. Satyavathi, D. Jasmine, K. Harshitha

Abstract :

There have been several attempts to define pain. McCafferey in the (1972) states that “pain is whatever the experiencing person says it is, existing whenever he or she says it does” . Inflammation is the bodies immediate response to damage to its tissues and cell by pathogens Noxious stimuli such as chemicals are physical injury.It is a protect to attempt by the Organism to remove the injurious stimuli as well as initiate the healing process for the tissue. Information can be classified as either acute or chronic status depending upon onset time Inflammation response is a serious off well coordinate dynamic mechanism consisting of specific vascular humoral and cellular events. Though a variety of chemical mediator or signaling molecule such as histamine, serotonin, leucotrienes, prostaglandins, are involved in the inflammatory response the mechanism of inflammatory injury is attributed in Part to release of ROS from activated neutrophils and macro phases.
Keywords: Painoff, Carrageenan, Poly-herbal, Eddy’s hot plate, Nociceptive pain.

Cite This Article:

Please cite this article in K Sivaji et al, Evaluation Of Anti –Inflammatory And Analgesic Activity Of Painoff By Following Animal Models., Indo Am. J. P. Sci, 2022; 09(9).

Number of Downloads : 10

References:

1. Ghosh S, May MJ, Kopp EB. “NF-k B and Rel proteins: Evolutionarily conserved mediators of immune responses”. Annu Rev Immunol. 1998; 16:225–60. [PubMed: 9597130]
2. http://holisticonline.com/Remedies/Backpain/back_pain-killers.htm
3. A text book of “Pharmacology and Pharmacotherapeutics” by R.S.Satoskar, N.Rege, S.D.Bhandarkar & Nirmai.
4. Divakar K, Pawar AT, Chandrasekhar SB, dighe SB, Divakar G. “Protective effect of hydro-alcoholic extract of rubia cordifolia roots against glycol indused urolithiasis in rats. Food and toxicology”. Article In press.
5. A text book of “Clinical Pharmacy and Therapeutics” by Roger Walker, Cate Whittlesea.
6. A text book of “Pharmacology” by H.P.Rang, M.M.Dale, J.M.Ritter, R.J.Flower.
7. A text book of “Essentials of Medical Pharmacology” by K.D.Tripathi.
8. A text book of “screening methods on pharmacology” by N. S. Parmar and Shiv Prakash
9. A text book of “Pharmacognosy” by C.K.Kokate, A.P.Purohit, S.B.Gokhale.
10. Seifried HE, Anderson DE, Fisher EI, Milner J.”A review of the interaction among dietary antioxidants and reactive oxygen species”. Journal of Nutritional Biochemistry.
11. Jagetia GC, Baliga MS (2005) “Radioprotection by mangiferin in DBAxC57BL mice: a preliminary study”. Phytomedicine 12, 209-215
12. Sarkar A, Sreenivasan Y, Ramesh GT, Manna SK (2004) “β-D-glucoside suppresses tumor necrosis factor-induced activation of nuclear transcription factor κB but potentiates apoptosis”. The Journal of Biological Chemistry 279, 33768-33781
13. Rivera DG, Balmaseda IH, Leon AA, Hernandez BC, Montiel LM, Garrido GG, Cuzzocrea S, Hernandez RD (2006) “Anti-allergic properties of Mangifera indica L. extract (Vimang) and contribution of its glucosylxanthone mangiferin”. Journal of Pharmacy and Pharmacology 58, 385-392
14. Garrido G, Gonzalez D, Lemus Y, Garcia D, Lodeiro L, Quintero G, Delporte C, Nuñez Selles AJ, Delgado R (2004) “In vivo and in vitro anti-inflammatory activity of Mangifera indica L. extract (Vimang®)”. Pharmacological Research 50, 143-149
15. Yoshimi N, Matsunaga K, Katayama M, Yamada Y, Kuno T, Qiao Z, Hara A, Yamahara J, Mori H (2001) “The inhibitory effects of mangiferin, a naturally occuring glucosylxanthone, in bowel carcinogenesis of male F344 rats”. Cancer Letters 163, 163-170
16. Muruganandan S, Gupta S, Kataria M, Lal J, Gupta PK (2002) “Mangiferin protects the streptozotocin-induced oxidative damage to cardiac and renal tissues in rats”. Toxicology 176, 165-173
17. Yoshikawa M, Nishida N, Shimoda H, Takada M, Kawahara Y, Matsuda H (2001) “Polyphenol constituents from Salacia species: Quantitative analysis of mangiferin with alpha-glucosidase and aldose reductase inhibitory activities”. Journal of the Pharmaceutical Society of Japan 121, 371-378
18. Stoilova I, Gargova S, Stoyanova A, Ho L (2005) “Antimicrobial and antioxidant activity of the polyphenol mangiferin”. Herbal Polonica 51, 37-44
19. Perrucci S, Fichi G, Buggiani C, Rossi G, Flamini G (2006) “Efficacy of mangiferin against Cryptosporidium parvum in a neonatal mouse model”. Parasitology Research 99, 184-188
20. A text book of “Pharmacognosy” by C.K.Kokate, A.P.Purohit, S.B.Gokhale.
21. Gülçin I, Elmastaş M, Aboul-Enein HY. “Antioxidant activity of clove oil-A powerful antioxidant source”. Arab J Chem 2012; 5(4): 489-499.
22. Devi KP, Nisha SA, Sakthivel R, Pandian SK. “Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane”. J Ethnopharmacol 2010; 130(1): 107-115.
23. Daniel AN, Sartoretto SM, Schimidt G, Caparroz-Assef SM, Bersani-Amado CA, Cuman RK. “Anti-inflamatory and antinociceptive activities of eugenol essential oil in experimental animal models”. Rev Bras Farmacogn 2009; 19(1B): 212-217.
24. Kurokawa M, Hozumi T, Basnet P, Nakano M, Kadota S, Namba T, et al. “Purification and characterization of eugeniin as an antiherpesvirus compound from Geum japonicum and Syzygium aromaticum”. J Pharmacol Exp Ther 1998; 284(2): 728-735.
25. Slamenová D, Horváthová E, Wsólová L, Sramková M, Navarová J. “Investigation of anti-oxidative, cytotoxic, DNA-damaging and DNA-protective effects of plant volatiles eugenol and borneol in human-derived HepG2, Caco-2 and VH10 cell lines”. Mutat Res 2009; 677(1-2): 46-52.
26. Sritabutra D, Soonwera M, Waltanachanobon S, Poungjai S. “Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) And Anopheles dirus Peyton & Harrion”. Asian Pac J Trop Biomed 2011; 1(Suppl 1): S124-S128.
27. Evaluation of analgesic, anti-pyretic and anti-inflammatory activities of the ethanol and dichloromethane extract from scaphium lychnophorum fruit in experiment animals
28. A text book of “Evaluation of Drug Activities: sPharmacometrics” by D.R. Laurence and A.L.Bacharach.
29. Nikajoo LT, “Analgesic activity of Aqueous and Alcohol root extracts of Pergularia daemia (forsk.) Chiov”. International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 1, Suppl 1, Nov.-Dec. 2009.
30. Janssen P A J, Niemegeers C J E & Dony J C G, “the inhibitory effect of fetanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflexe in rats”, drug res, 13 (1963) 502.
31. Eming, S. A.; Krieg, T.; Davidson, J. M. (2007). “Inflammation in wound repair: molecular and cellular mechanisms”. Journal of Investigative Dermatology.
32. Abbas A.B.; Lichtman A.H. (2009). “Ch.2 Innate Immunity”.Basic Immunology. Functions and disorders of the immune system (3rd ed.). ISBN 978-1-4160-4688-2.
33. Essentials of Pharmacology, 6th edition, K.D. Tripathi.
34. Acacia melanoxylon Porter, Terry (2006). Wood: Identification and Use. East Sussex, GB: Guild of Master Craftsman Publications Ltd. pp.37.
35. This species was first named and described in Bijdragen tot de Flora van Nederlandsch Indie 13: 657. 1826 “Plant Name Details for Sambucusjavanica”.
36. Ozaki, Y; Kawahara, N; Harada, M (1991). “Anti-inflammatory effect of ZingibercassumunarRoxb. And its active principles”. Chemical & pharmaceutical bulletin.
37. Krishnaveni B, Neeharica V,Srikanth AV, Madavareddy B ,Anti-inflammatory activity of Carallia brachiata bark,Department of pharmacognasy and phytochemistry,G Pulla reddy college of pharmacy
38. WHO guidelines,1990 – Acute toxicity studies..
39. Kokate CK, Purohit AP, GokhaleSb, Pharmacognosy, 3rd edition, NiraliPrakashan, Pune
40. Khandelwal KR (2006). Practical Pharmacognosy. NiraliPrakashan, Pune.
41. Anti-inflammatory activity of Caralliabrachiata bark, Krishnaveni B, NeeharicaV,Srikanth AV, MadavareKhandelwal KR (2006). PracticalPharmacognosy. NiraliPrakashan, Pune.