Volume : 09, Issue : 09, September – 2022
Title:
37.DEVELOPMENT AND EVALUATION OF PHYTOSOMES OF EXTRACT OF HELICTERES ISORA FOR EFFECTIVE TREATMENT OF DIABETES
Authors :
Tejesh Harode*, Dr. Vishnu Raj, Dr. Brijesh Sirohi, Dr. Shailendra Lariya
Abstract :
Helicteres isora L. is a large arborescent shrub of the family Sterculiaceae. It is used as an anti gastro spasmodic, anthelmintic, antispasmodic, antipyretic, anti diarrheal, anti dysenteric and as a tonic after childbirth. Stems of this plant are used as anthelmintic, colic, and aphtha, while fruits are used as colic, anticonvulsant, and abdominalgia. The aim of present work to prepare and characterize Helicteresisora extracts loaded phytosomes for effective treatment diabetes. Entrapment efficiency is an important parameter for characterizing phytosomes. In order to attain optimal encapsulation efficiency, several factors were varied, including the concentration of the lipid, concentration of drug and concentration of alcohol. The entrapment efficiency of all the prepared formulations is shown in Table 7.6. The entrapment efficiency of the phytosomes was found in the range of 55.85 to 70.25%. Particle size of all formulations found within range 310.32-385.45nm. Concentration of lipid has shows significant impact on size of phytosomes. Formulation F10 was found best one which is further evaluated for drug release study, transmission electron microscopy (TEM), and stability studies. In this study, the combined hydroalcoholic extract of Helicteres isora in ratio of 2:1:1 found to exhibit significant results. Phytosomes has better physical characteristics than that of extract. In-vitro studies revealed that phytosomes showed control release of phytoconstituents. Hence, phytosomal formulation of this herbal drug combination can be used for clinical application to enhance the therapeutic effect.
Key Words: Helicteresisora, Phytosomes, Formulation, Evaluation.
Cite This Article:
Please cite this article in Tejas Harode et al, Development And Evaluation Of Phytosomes Of Extract Of Helicteres Isora For Effective Treatment Of Diabetes., Indo Am. J. P. Sci, 2022; 09(9).
Number of Downloads : 10
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