Volume : 09, Issue : 09, September – 2022
Title:
38.SMART POLYMERS FOR STIMULI RESPONSIVE DRUGS
Authors :
Pradip Ganesh Landge*, Dr. Sameer Shafi , Avinash Ramling Swami, Pankaj Dattatray Dhage, Vishweshwar Dharashive
Abstract :
Smart polymers are the polymeric materials which respond to minute external stimuli are of utmost significance in the domain of pharmaceutical sciences. It has also been known as “stimuli responsive” materials or “intelligent” materials. The stimuli which induce the conformational changes in the polymers includes salt, UV irradiation, temperature, pH, magnetic or electric field, and ionic variables. Emphasizing on the delivery of the therapeutic molecule at the site of action, smart polymer’s responsiveness to the stimuli makes it a perfect candidate of the novel drug delivery system. Besides delivery the therapeutic molecule it is also employed in cell culture, gene carriers, textile engineering, oil recovery, radioactive waste, and protein purification. Possibility of administering therapeutic agents to a patient in an optimum release pattern has been an ultimate aim of researchers in the domain of drug delivery. Soft materials with similar shear modulus or mechanical strength to human body tissues have been highly focused in the decades, especially those soft materials with unique properties that we called “smart polymeric materials”. Smart materials, which are synthetic materials with one or more properties that can be significantly altered in a controlled manner by external stimuli. Internal stimuli-responsive smart biomaterials include those that respond to specific enzymes or changes in microenvironment pH; external stimuli can consist of electromagnetic, light, or acoustic energy; with some smart biomaterials responding to multiple stimuli. In the present article effects are taken to give overview on type of smart polymer, their mechanisms, components and applications.
Keywords :- Smart polymers, Stimuli Responsive, Soft Materials, Shear Modulus, Stimuli
Cite This Article:
Please cite this article in Pradip Ganesh Landge et al, Smart Polymers For Stimuli Responsive Drugs., Indo Am. J. P. Sci, 2022; 09(9).
Number of Downloads : 10
References:
1) Aguilar MR, San Román J. Smart polymers and their applications, 2rd ed. Woodhead Publishing; 2019.
2) Hollingshead S, Lin CY, Liu JC. Designing Smart Materials with Recombinant Proteins. Macromol Biosci. 2017;17(7).
3) Wei M, Gao Y, Li X, Serpe MJ. Stimuli-responsive polymers and their applications. Polym Chem. 2017;8(1):127–43.
4) Liu Y, Hsu SH. Synthesis and biomedical applications of self-healing hydrogels. Front Chem. 2018; 6:449.
5) Michael Harris, Landon Choi. Stimuli-Responsive Drug Release from Smart Polymers, Published; 2019.
6) Ganta, S.; Devalapally, H.; Shahiwala, A.; Amiji, M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Contr. Release 2008, 126, 187–204.
7) Wei, M.; Gao, Y.; Li, X.; Serpe, M.J. Stimuli-responsive polymers and their applications. Polym. Chem. 2017, 8, 127–143.
8) Kocak, G.; Tuncer, C.; Butun, V. Ph-responsive polymers. Polym. Chem. 2017, 8, 144–176.
9) Son, S.; Shin, E.; Kim, B.-S. Light-responsive micelles of spiropyran initiated hyperbranched polyglycerol for smart drug delivery. Biomacromolecules 2014, 15, 628–634.
10) De La Rica, R.; Aili, D.; Stevens, M.M. Enzyme-responsive nanoparticles for drug release and diagnostics. Adv. Drug Deliv. Rev. 2012, 64, 967–978.
11) Hu, Q.; Katti, P.S.; Gu, Z. Enzyme-responsive nanomaterials for controlled drug delivery. Nanoscale 2014, 6, 12273–12286.
12) Fleige, E.; Quadir, M.A.; Haag, R. Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications. Adv. Drug Deliv. Rev. 2012, 64, 866–884.
13) Hung-Jin Huang , Yu-Liang Tsai. Smart polymers for cell therapy and precision medicine, publishing; 2019.
14) Gore SA, Gholve SB, Savalsure SM, Ghodake KB, Bhusnure OG, Thakare VM. Smart polymer and their applications: A review. Int. J. Curr. Pharm. Rev. Res. 2017;8:298-310.
15) Ward MA, Georgiou TK. Thermoresponsive polymers for biomedical applications. Polymers. 2011 Sep;3(3):1215-42.
16) R Jadhav K, S Pacharane S, V Koshy P, J Kadam V. Smart polymers and their role in drug delivery: A review. Current Drug Therapy. 2010 Nov 1;5(4):250-61.
17) Aguilar MR, San Román J, editors. Smart polymers and their applications. Woodhead publishing; 2019 Feb 15.
18) Alarcon CD. de las H., Pennadam, S. & Alexander, C. Stimuli responsive polymers for biomedical applications. Chem. Soc. Rev. 2005;34(3):276-85.
19) Pandey S, Pandey S. Smart Polymers: A boon in Drug delivery. International Journal of Pharmacy & Life Sciences. 2021 Feb 1;12(2).
20) Subham Ghosh, Smita Rai. A review on the therapeutic efficacy of Smart polymers in the pharmaceutical domain. Volume 7, Issue 2 Mar-Apr 2022, pp: 421-431
21) Honey Priya James, Anju Alex, Smart polymers for the controlled delivery of drugs. Publishing; 2014.