Volume : 09, Issue : 09, September – 2022
Title:
40.OPTIMIZATION AND CHARACTERIZATION OF MICROEMULSION FOR NASAL DRUG DELIVERY
Authors :
Rathod Sayali P*., Jadhao U.T., Ghogare Jyoti . D, Panchal Pranita P.
Abstract :
The present study was aimed to develop and evaluate micro emulsion of Ibuprofen for intranasal delivery. Micro emulsion formed by Capmul PG8, tween 80, propylene glycol is clear, transparent and stable. Among various formulations formulated ME-1, ME-2, ME-3, ME-4, ME-5, ME-6 were clear, transparent and stable. Globule size of final optimized formulation ME-5 had a diameter of 155.4 nm and width of 36.65 nm; this confirms the Isotropic nature of micro emulsion In vitro diffusion study was also done on bovine nasal mucosa. the release of the drug from the formulation showed a lag time of 30 min. 42.11% of drug was released Micro emulsion showed higher drug release which may be due to solubility enhancing of surfactant and co-surfactant. The microemulsion systems are transparent and stable at ambient conditions for 1 month. Stability study was carried out at 40ºC & 75% RH for one month. Formulation was stable for total period of study.
Keywords- Microemulsion, Capmul, Nasal drug delivery, surfactant.
Cite This Article:
Please cite this article in Sayali P.Rathod et al, Optimization And Characterization Of Microemulsion For Nasal Drug Delivery., Indo Am. J. P. Sci, 2022; 09(09).
Number of Downloads : 10
References:
1. Hicke A.J., Pharmaceutical Inhalation Aerosol Technology, 2nd ed Marcel Dekker, Inc: NewYork, 2004
2. Illum L. Nasal drug delivery-possibilities, problems and solutions. J Control Release.2003; 87: 187–198.
3. Arora P., Sharma. Gary S. Permeability issues in nasal drug delivery. Drug Discov Today. 2002; 7: 967–975.
4. Graff L.C., Pollock G.M. Nasal drug administration: potential for targeted central nervous system delivery. J Pharm Sci. 2005; 94:1187-1195.
5. CIllum L. Nasal drug delivery: new developments and strategies. Drug Discov Today. 2002; 7:1184- 1189.
6. Lipworth B.J., and Jackson C.M. Safety of inhaled and intranasal corticosteroids: lessons for the new millennium. Drug Saf. 2000; 23: 11–33.
7. Duquesnoy C., Mamet J.P., Sumner D., and Fuseau E. Comparative clinical pharmacokinetics of single doses of sumatriptan following subcut anus, oral, rect al and intranasal administration. Eur J Pharm Sci. 1998; 6:99-104.
8. Behl C,R., Pimplaskar N.K., Sileno A.P., Demeireles J., Romeo VD. Effect of physicochemical properties and other factors on nasal drug delivery. Advanced drug delivery Reviews. 1998; 89-116.
9. Dhembre N. Gunesh, Formulation and evaluation of nanosponge gel containing ketoconazole. Innov Pharm Pharmacother 2021;9(1):15-24.
10. Rathod Sayali P,., Formulation and critical evaluation of piroxicam gel., The Pharma Innovation Journal 2021; 10(3): 89-94
11. Duerst, M., 2007. Spectroscopic methods of analysis: Infrared spectroscopy. In: Swarbrick J., Boylon J.C., Encyclopedia of Pharmaceutical Technology. 3rd Ed. vol. 5. Marcel Dekker Inc. New York, pp. 3405- 3418
12. Hoar TP, Schulman JH. Transparent Water in oil dispersions: the oleopathic hydromicelle. Nature 1943; 152:102-103.
13. Thoke S.T, Formulation And Development Of Indomethacin Polymeric Sustain Release Microsponges., IAJPS 2021, 08 (9), 317-325.,
14. Rupesh Patil,., Formulation and in-vitro evaluation of oral Hydrogel containing miconazole nitrate., AJPER October – December 2017;6, (4) ;45-56.
15. Hsiu-O Ho, Chih-Chuan Hsiao, Ming-Thau Sheu, preparation of microemulsions using polyglycerol fatty acid esters as surfactant for the delivery of protein drugs. J. pharm. Sci. 1996; 58: 138-143.
16. Ohwaki K., Ando H., Watanabe S., Miyake Y. Effects of Krenistsky, Amino acid ester prodrugs of acyclovir, Antiviral dose, pH, and osmolarity on nasal absorption of secretin in Chem. Chemother., 1992;3:157–164.
17. Clement P., Roovers M.H., Francillon C., Dodion P. Dose ranging, placebo controlled study of cetrizine nasal spray in adults with perennial allergic rhinitis. Allergy 1994; 49: 668–672.
18. Tekade B. W., Development and In-Vitro Evaluation of Capecitabine Microspheres by Emulsification Solvent Evaporation Method. Ijppr. Human, 2017; Vol. 10 (2): 149-162.
19. ICH Harmonised Tripartite Guideline, Stability Testing of New Drug Substance and Products Q1A (R2). Current step 4 version: 8.
20. Watson, D.G., 1999. Pharmaceutical Analysis A textbook for pharmacy students and pharmaceutical chemists, first ed. London, Churchill Livingstone. Pp.100-03.
21. Skoog, D.A., Holler, F.J., Nieman, T.A., 2004. Principles of Instrumental Analysis. 5 th ed. Sounder’s College Publishing, pp. 798- 808.