Volume : 09, Issue : 09, September – 2022
Title:
42.DEVELOPMENT AND CHARACTERIZATION OF BILAYER TABLET DOSAGE FORM FOR TREATMENT OF BACTERIAL DISEASE
Authors :
Ravikant Thakur, RS Kushwaha, Neeraj Sharma, Naveen Gupta, Dharmendra S Rajput, Ankita Shukla
Abstract :
Controlled-release buoyant bilayer tablets reduce dosage system improve patient compliance with enhanced therapeutic action. It is a single dosage system have, two different tablets layers of clarithromycin and lansoprazole, respectively, are given for the treatment of bacterial infection and it might be worth incorporating both in a single tablet. The main objective of the present research work was emphasized on development and characterizes a bilayer tablet of Clarithromycin and Lansoprazole with separate layers to avoid incompatibility. The bilayered tablet gives biphasic drug release through loading dose; prepared using croscarmellose sodium as a superdisintegrant for immediate release of lansoprazole and HPMC K 15 polymer used for maintenance dose of clarithromycin using several viscosity grades of hydrophilic polymers. Bilayered tablet were evaluated for hardness, thickness, friability, drug content uniformity and in vitro drug dissolution.
Keywords: Controlled release, buoyant bilayer tablets, Clarithromycin and Lansoprazole
Cite This Article:
Please cite this article in Ravikant thakur et al, Development And Characterization Of Bilayer Tablet Dosage Form For Treatment Of Bacterial Disease., Indo Am. J. P. Sci, 2022; 09(9).
Number of Downloads : 10
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