Volume : 10, Issue : 01, January – 2023



Authors :

Upendra N , J S Venkatesh , Josy Varghese , Jeeshna Jayan , Devi Dileep , Jeena M Jacob

Abstract :

An autoimmune disease called rheumatoid arthritis affects 0.5% to 1 of the general population. Due to hormonal factors, women are more likely to experience it. Pain and swelling are the main symptoms brought on by synovial inflammation, despite the fact that the specific etiopathology is unknown. Even while analgesics and biological treatments can put rheumatoid arthritis into remission, the condition is generally thought to be incurable. The 2019 coronavirus infection outbreak that it created had a devastating impact on the entire world. COVID-19 disease affected or killed people who had autoimmune conditions, compromised immune systems, or elderly people. Although there is a substantial danger of transmission, it seldom causes death. Organ failure and cytokine storm are two of the disease’s main clinical signs and symptoms. A patient would find it extremely difficult to live with such a clinical picture, which necessitates serious medical treatment.
Key words: Rheumatoid arthritis, Covid-19, Cytokine storm, Immunoglobulins, Interleukins.

Cite This Article:

Please cite this article in press Upendra N et al, A Correlation Between Rheumatoid Arthritis And Covid-19., Indo Am. J. P. Sci, 2023; 10 (01).

Number of Downloads : 10


1. Okamoto H, Cuje TP, Yamanaka H, Kamatani N (2008) Molecular Aspects of Rheumatoid Arthritis: Role Oftranscription Factors. The Febs Journal 275(18): 4463-4470.
2. Oliver JE, Silman AJ (2006) Risk Factors for the Development of Rheumatoid Arthritis. Scand J Rheumatol 35(3): 169-174.
3. Colak A, Sertpoyraz FM, Baysol A, Girgin EM, Taylan A (2020) IschemiaModified Albumin as an Indicator of Disease Activity in Rheumatoid Arthritis. Journal of Turkish Clinical Biochemistry 18(3): 144-149.
4. Visser H (2005) Early Diagnosis of Rheumatoid Arthritis. Best Practice & Research Clinical Rheumatology 19(1): 55-72.
5. Park SE (2020) Epidemiology, Virology, and Clinical Features of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2; Coronavirus Disease-19). Clinical and Experimental Pediatrics 63(4): 119-124.
6. Ladner U, Pap T, Gay R, Neidhart M, Gay S (2005) Mechanisms of Disease: The Molecular and Cellular Basis of Joint Destruction in Rheumatoid Arthritis. Nature Clinical Practice 1(2): 102-110.
7. Firestein G, McInnes IB (2017) Immunopathogenesis of Rheumatoid Arthritis. Immunity 46(2): 183-192.
8. Edwards CJ (2008) Commensal Gut Bacteria and the Etiopathogenesis of Rheumatoid Arthritis. The Journal of Rheumatology 35(8): 1477-1479.
9. Sceherer HU, Häupl T, Burmester GR (2020) The Etiology of Rheumatoid Arthritis. Journal of Autoimmunity 110: 102400.
10. Cojocaru M, Cojocaru IM, Silosi I, Vrabie CD, Tanasescu R (2010) Extraarticular Manifestations in Rheumatoid Arthritis. Maedica 5(4): 286-291.
11. Kulle S (2009) The Relationship of Anti-CCP Antibody Levels with Clinical, Laboratory and Radiological Findings in Patients with Rheumatoid Arthritis. Specialization Thesis, Ankara University, Institute of Health Sciences.
12. Bes C (2015) Rheumatoid Arthritis-Associated Interstitial Lung Disease. J Turk Soc Rheumatol 7(2): 41-46.
13. Zhang M, Wang M, Tai Y, Tao J, Zhou W, et al. (2021) Triggers of Cardiovascular Diseases in Rheumatoid Arthritis. Curr Probl Cardiol 0: 100853.
14. Vreugdenhil G, Wognum AW, Eijk HG, Swaak AJ (1990) Anaemia in Rheumatoid Arthritis: The Role of Iron, Vitamin B12 and Folic Acid Deficiency and Arythropoietin Responsiveness. Annals of the Rheumatic Diseases 49(2): 93-98.
15. Keenan RT, Swearingen CJ, Yazici Y (2008) Erythrocyte Sedimentation Rate and C-Reactive Protein Levels are Poorly Correlated with Clinical Measures of Disease Activity in Rheumatoid Arthritis, Systemic Lupus Erythematosus and Osteoarthritis Patients. Clinical and Experimental Rheumatology 26(5): 814-819.
16. Pope JE, Choy EH (2021) C-Reactive Protein and Implications in Rheumatoid Arthritis and Associated Comorbidities. Seminars in Arthritis and Rheumatism 51(1): 219-229.
17. Kokubun M, Imafuku Y, Okada M, Ohguchi Y, Ashikawa T, et al. (2005) Serum Amyloid A (SAA) Concentration Varies Among Rheumatoid Arthritis Patients Estimated by SAA / CRP Ratio. Clinica Chimica Acta 360(1-2): 97-102.
18. Nakamura RM (2000) Progress in the Use of Biochemical and Biological Markers for Evaluation of Rheumatoid Arthritis. Journal of Clinical Laboratory Analysis 14(6): 305-313.
19. Ingegnoli F, Castelli R, Gualtierotti R (2013) Rheumatoid Factors: Clinical Application. Disease Markers 35(6): 727-734.
20. Block DR, Jenkins SM, Dalenberg DA, Balsanek JG, Snyder MR, et al. (2012) Analytical and Clinical Comparison of Anti-CCP Assays with Rheumatoid Factor for the Diagnosis of Rheumatoid Arthritis. Clinica Chimica Acta 413(11-12): 1015-1017.
21. Reparon Schuijt CC, Esch WJE, Kooten C, Schellekens GA, Jong B, et al. (2001) Secretion of Anti-citrulline Containing Peptide Antibody by B Lymphocytes in Rheumatoid Arthritis. Arthritis & Rheumatism 44(1): 41-47.
22. Wang Q, Zhang Y, Wu L, Niu S, Sarkı C, et al. (2020) Structural andFunctional Basis of SARS-CoV-2 Entry by Using Human ACE2. Cell181(4): 894-904.
23. Świerkot J, Szechiński J (2006) Methotrexate in Rheumatoid Arthritis. Pharmacogical Reports 58(4): 473-492.
24. Goldenberg MM (1999) Leflunomide, A Novel Immunomodulator for the Treatment of Active Rheumatoid Arthritis. Clinical Therapeutics 21(11):1837-1852.
25. Dhama K, Han S, Tiwari R, Sircar S, Bhat S, et al. (2020) Coronavirus Disease 2019-COVID-19. Clinical Microbiology Reviews 33(4).
26. Schoeman D, Fielding BC (2019) Coronavirus Envelope Protein: Current Knowledge. Virology Journal 16(1): 69.
27. Duart G, García Murria MJ, Mingarro I (2021) The SARS-CoV-2 Envelope (E) Protein Has Evolved Towards Membrane Topology Robustness. BBABiomembranes 1863(7): 183608.
28. Masters PS (2006) The Molecular Biology of Coronaviruses. Advances in Virus Research 66: 193-292.
29. Nile SH, Nile A, Qiu J, Li L, Jia X, et al. (2020) COVID -19: Pathogenesis, Cytokine Storm and Therapeutic Potential of Interferons. Cytokine and Growth Factor Reviews 53: 66-70.
30. Hoffmann M, Kleine Weber H, Schroeder S, Krüger N, Herrler T, et al. (2020) SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and is Blocked by a Clinically Proven Protease Inhibitor. Cell 181(2): 271-280.
31. Fehr AR, Perlman S (2015) Coronaviruses: An Overview of Their Replication and Pathogenesis. Nature Public Healthy Emergency Collection 1282: 1-23.
32. Setti L, Passarini F, De Gennaro G, Barbieri P, Licen S, et al. (2020) Potential Role of Particulate Matter in the Spreading of COVID-19 in Northern Italy: First Observational Study Based on Initial Epidemic Diffusion. BMJ Open 10(9): e039338.
33. Rothan HA, Byrareddy SN (2020) The Epidemiology and Pathogenesis of Coronavirus Disease (COVID-19) Outbreak. Journal of Autoimmunity 109: 102433.
34. Jin Y, Yang H, Ji W, Wu W, Chen S, et al. (2020) Virology, Epidemiology, Pathogenesis, and Control of COVID-19. Viruses 12(4): 1-17.
35. Yang L, Liu S, Liu J, Zhang Z, Wan X, et al. (2020) COVID-19: Immunopathogenesis and Immunotherapeutics. Signal Transduction and Targeted Therapy 5(1): 128.
36. Pechous RD, Sivaraman V, Price PA, Stasulli NM, Goldman WE (2013) Early Host Cell Targets of Yersinia Pestis During Primary Pneumonic Plaque. PLoS Pathogens 9(10): e1003679.
37. Fajgenbaum DC, June CH (2020) Cytokine Storm. The New England Journal of Medicine 383(23): 2255-2273.
38. Chen Z, Xu W, Ma W, Shi X, Li S, et al. (2021) Clinical Laboratory Evaluation of COVID-19. Clinica Chimica Acta 519: 172-182.
39. Liu DX, Liang JQ, Fung TS (2020) Human Coronavirus-229E, OC43, NL63, and HKU1 (Coronaviridae). Encyclopedia of Virology 2: 428-440.
40. Guan W, Ni Y, Liang W, Ou C, He J, et al. (2020) Clinical Characteristics of Coronavirus Disease 2019 in China. The New England Journal of Medicine 382(18): 1708-1720.
41. Yao XH, Li TY, He ZC, Ping YF, Liu HW, et al. (2020) A Pathological Report of Three COVID-19 Cases by Minimal Invasive Autopsies. Chinese Journal of Pathology 49(5): 411-417.
42. Riawati T, Indrarto W, Fauzi AR, Widitjiars W, Gunadi (2021) Various Radiological Findings in Patients with COVID-19: A Case Series. Annals of Medicine and Surgery 62: 269-273.
43. Amano Y, Kage H, Tanaka G, Gonoi W, Nakai Y, et al. (2021) Diagnostic Prediction of COVID-19 Based on Clinical and Radiological Findings in A Relatively Low COVID-19 Prevalence Area. Respiratory Investigation 59(4): 446-453.
44. Chamorro EM, Tascόn AD, Sanz LI, Vѐlez SO, Nacenta SB (2021) Radiologic Diagnosis of Patients with COVID-19. Radiología 63(1): 56-73.
45. Li J, Long X, Wang X, Fang F, Lv X, et al. (2021) Radiology Indispensable for Tracking COVID-19. Diagnostic and Interventional Imaging 102(2): 69-75.
46. Lester M, Sahin A, Pasyar A (2020) The Use of Dexamethasone in the Treatment of COVID-19. Annals of Medicine and Surgery 56: 218-219.
47. Hassan ME, Hasan HMSN, Sridharan K, Elkady A, ElSeirafi MMA (2020) Dexamethasone in Severe COVID-19 Infection: A Case Series, Respiratory Medicine Case Reports 31: 101205.
48. Lam S, Lombardi A, Ouanounou A (2020) COVID-19: A Review of the Proposed Pharmacological Treatments. European Journal of Pharmacology 886: 173451.
49. Furuta Y, Takahashi K, Fukuda Y, Kuno M, Kamiyama T, et al. (2002) In Vitro and in Vivo Activities of Anti-Influenza Virus Compound T-705. Antimicrob Agents Chemother 46(4): 977-981.
50. Delang L, Abdelnabi R, Neyts J (2018) Favipiravir As a Potential Countermeasure Against Neglected and Emerging RNA Viruses. Antiviral Research 153: 85-94.
51. Terracina KA, Tan FK (2021) Flare of Rheumatoid Arthritis After COVID -19 Vaccination. The Lancet Rheumatology 3(7): e469-e470.
52. Favalli EG, Ingegnoli F, Lucia O, Cincinelli G, Cimaz R, et al. (2020) COVID-19 Infection and Rheumatoid Arthritis: Faraway, So Close!. Autoimmunity Reviews 19(5): 102523.
53. Conway R, Konig MF, Graef ER, Webb K, Yazdany J, et al. (2021) Inflammatory Arthritis in Patients with COVID-19. Translational Research 232: 49-59.