Volume : 10, Issue : 01, January – 2023
Title:
53.BIOMARKERS OF BRONCHIAL ASTHMA
Authors :
Vinuth Chikkamath, J. S. Venkatesh, Varsha K*, Vamshi D*, Jahangir Alom*
Abstract :
Asthma is a complex disease with a variable course. Biomarker research has expanded greatly with the advancement of molecular research techniques. A biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient. An ideal biomarker should be suitable to identify the disease as well the specific endotype/phenotype, useful in the monitoring of the disease and to determine the prognosis, easily to obtain with minimum discomfort or risk to the patient – exhaled breath analysis, blood cells and serum biomarkers, sputum cells and mediators and urine metabolites could be potential biomarkers of asthma bronchiale. Presently an ideal biomarker doesn’t exist and the overlap between the biomarkers is a reality.
Key words: Biomarkers, Bronchial asthma
Cite This Article:
Please cite this article in press Vinuth Chikkamath et al, Biomarkers Of Bronchial Asthma., Indo Am. J. P. Sci, 2023; 10 (01).
Number of Downloads : 10
References:
1. PAPI A, BRIGHTLING C, PEDERSEN SE, REDDEL HK: Asthma. Lancet 391: 783-800, 2018.
2. FITZPATRICK AM: Biomarkers of asthma and allergic airway diseases. Ann Allergy Asthma Immunol 115: 335-340, 2015.
3. MEDREK SK, PARULEKAR AD, HANANIA NA: Predictive biomarkers for asthma therapy. Curr Allergy Asthma Rep 17: 69, 2017.
4. DWEIK RA, BOGGS PB, ERZURUM SC, IRVIN CG, LEIGH MW, LUNDBERG JO, OLIN AC, PLUMMER AL, TAYLOR DR: American Thoracic Society Committee on Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med 184: 602-615, 2011.
5. ANTOSOVA M, MOKRA D, PEPUCHA L, PLEVKOVA J, BUDAY T, STERUSKY M, BENCOVA A: Physiology of nitric oxide in the respiratory system. Physiol Res 66 (Suppl 2): S159-S172, 2017a.
6. ANTOSOVA M, MOKRA D, TONHAJZEROVA I, MIKOLKA P, KOSUTOVA P, MESTANIK M, PEPUCHA L, PLEVKOVA J, BUDAY T, CALKOVSKY V, BENCOVA A: Nasal nitric oxide in healthy adults – reference values and affecting factors. Physiol Res 66 (Suppl 2): S247-S255, 2017b.
7. TOPERCEROVA J, KOLOMAZNIK M, KOPINCOVA J, NOVA Z, URBANOVA A, MOKRA D, MOKRY J, CALKOVSKA A: The effect of pulmonary surfactant on the airway smooth muscle after lipopolysaccharide exposure and its mechanisms. Physiol Res 68 (Suppl 3): S275-S285, 2019.
8. CHUNG KF, WENZEL SE, BROZEK JL, BUSH A, CASTRO M, STERK PJ, ADCOCK IM, BATEMAN ED, BELEH, BLEECKER ER, BOULET LP, BRIGHTLING C, CHANEZ P, DAHLEN SE, DJUKANOVIC R, FREY U, GAGA M, GIBSON P, HAMID Q, JAJOUR NN, MAUAD T, SORKNESS RL, TEAGUE WG: International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 43: 343-373, 2014.
9. ROBROEKS CM, VAN BERKEL JJ, JÖBSIS Q, VAN SCHOOTEN FJ, DALLINGA JW, WOUTERS EF, DOMPELING E: Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study. Eur Respir J 42: 98-106, 2013.
10. EGUILUZ-GRACIA I, TAY TR, HEW M, ESCRIBESE MM, BARBER D, O’HEHIR RE, TORRES MJ: Recent developments and highlights in biomarkers in allergic diseases and asthma. Allergy 73: 2290-2305, 2018.
11. KOH GC, SHEK LP, GOH DY, VAN BEVER H, KOH DS: Eosinophil cationic protein: is it useful in asthma? A systematic review. Respir Med 101: 696-705, 2007.
12. TIOTIU A: Biomarkers in asthma: state of the art. Asthma Res Pract 4: 10, 2018.
13. GRAYSON MH, FELDMAN S, PRINCE BT, PATEL PJ, MATSUI EC, APTER AJ: Advances in asthma in 2017: Mechanisms, biologics, and genetics. J Allergy Clin Immunol 142: 1423-1436, 2018.
14. LOPEZ-GUISA JM, POWERS C, FILE D, COCHRANE E, JIMENEZ N, DEBLEY JS: Airway epithelial cells from asthmatic children differentially express proremodeling factors. J Allergy Clin Immunol 129: 990-997, 2012.
15. SEMPRINI R, CASWELL-SMITH R, FINGLETON J, HOLWEG C, MATTHEWS J, WEATHERALL M, BEASLEY R, BRAITHWAITE I: Periostin Study Team. Longitudinal variation periostin levels in adults with stable asthma. J Allergy Clin Immunol 139: 1687-1688, 2017
16. SILKOFF PE, LAVIOLETTE M, SINGH D, FITZGERALD JM, KELSEN S, BACKER V, PORSBJERG CM, GIRODET PO, BERGER P, KLINE JN, CHUPP G, SUSULIC VS, BARIBAUD F, LOZA MJ, Airways Disease Endotyping for Personalized Therapeutics (ADEPT) study investigators: Identification of airway mucosal type 2 inflammation by using clinical biomarkers in asthmatic patients. J Allergy Clin Immunol 140: 710-719, 2017.
17. PORTELLI MA, MOSELEY C, STEWART CE, POSTMA DS, HOWARTH P, WARNER JA, HOLLOWAY JW, KOPPELMAN GH, BRIGHTLING C, SAYERS I: Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients. Allergy 72: 473-482, 2017.
18. MIDYAT L, GULEN F, KARACA E, OZKINAY F, TANAC R, DEMIR E, COGULU O, ASLAN A, OZKINAY C, ONAY H, ATASEVER M: MicroRNA expression profiling in children with different asthma phenotypes. Pediatr Pulmonol 51: 582-587, 2016.
19. SHIMODA T, OBASE Y, KISHIKAWA R, IWANAGA T: Serum high-sensitivity C-reactive protein can be an airway inflammation predictor in bronchial asthma. Allergy Asthma Proc 36: e23-8, 2015.
20. NAIK SP, P A M, B S J, MADHUNAPANTULA SV, JAHROMI SR, YADAV MK: Evaluation of inflammatory markers interleukin-6 (IL-6) and matrix metalloproteinase-9(MMP-9) in asthma. J Asthma 54: 584-593, 2017.
21. LIU HC, LU MC, LIN YC, WU TC, HSU JY, JAN MS, CHEN CM: Differences in IL-8 in serum and exhaled breath condensate from patients with exacerbated COPD or asthma attacks. J Formos Med Assoc 113: 908-914, 2014.
22. MOORE WC, HASTIE AT, LI X, LI H, BUSSE WW, JARJOUR NN, WENZEL SE, PETERS SP, MEYERS DA, BLEECKER ER, National Heart, Lung, and Blood Institute’s Severe Asthma Research Program: Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis. J Allergy Clin Immunol 133: 1557-1563, 2014.
23. DEMARCHE SF, SCHLEICH FN, PAULUS VA, HENKET MA, VAN HEES TJ, LOUIS RE: Asthma control and sputum eosinophils: a longitudinal study in daily practice. J Allergy Clin Immunol Pract 5: 1335-1343, 2017.
24. COWAN DC, TAYLOR DR, PETERSON LE, COWAN JO, PALMAY R, WILLIAMSON A, HAMMEL J, ERZURUM SC, HAZEN SL, COMHAIR SA: Biomarker-based asthma phenotypes of corticosteroid response. J Allergy Clin Immunol 135: 877-883, 2015.
25. NAIR P, OCHKUR SI, PROTHEROE C, RADFORD K, EFTHIMIADIS A, LEE NA, LEE JJ: Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. Allergy 68: 1177-1184, 2013.
26. MAES T, COBOS FA, SCHLEICH F, SORBELLO V, HENKET M, DE PRETER K, BRACKE KR, CONICKX G, MESNIL C, VANDESOMPELE J, LAHOUSSE L, BUREAU F, MESTDAGH P, JOOS GF, RICCIARDOLO FL, BRUSSELLE GG, LOUIS R: Asthma inflammatory phenotypes show differential microRNA expression in sputum. J Allergy Clin Immunol 137: 1433-1446, 2016
27. IWAMOTO H, GAO J, KOSKELA J, KINNULA V, KOBAYASHI H, LAITINEN T, MAZUR W: Differences in plasma and sputum biomarkers between COPD and COPD-asthma overlap. Eur Respir J 43: 421-429, 2014.
28. CANONICA GW, FERRANDO M, BAIARDINI I, PUGGIONI F, RACCA F, PASSALACQUA G, HEFFLER E: Asthma: personalized and precision medicine. Curr Opin Allergy Clin Immunol 18: 51-58, 2018.