Volume : 10, Issue : 01, January – 2023

Title:

61.PHARMACOLOGICAL EVALUATION OF EUPHORBIA HIRTA L. FOR DIABETES AND DIABETIC DYSLIPIDEMIA

Authors :

Shailendra Kumar Gupta *, Sailesh kumar Ghatuary, Satkar Prasad, Saurav Jain

Abstract :

The present research study was entitled focused on the importance of crude plant extract as promising treatments. In continuation, the active component responsible for medicinal properties from this plant were isolated and assessed for its mechanism by α-glucosidase and DPP IV inhibitory activity. In-vivo toxicity studies and pharmacological activity of extract and isolated compounds were carried out and compared with standard drugs; sitagliptin and miglitol.
Experimental work performed in this thesis consists of four parts. The first part dealt with phytochemical evaluation and isolation of active constituents. In second part, the in-vitro enzyme inhibitory activity was carried out and third part involves toxicity assessments of the plant and isolated compounds. Final part dealt with in-vivo efficacy of extract and potent isolated compounds in HFD fed and low STZ induced type 2 DM model.
Qualitative phytochemical analysis have shown the presence of flavonoids, tannins, phenolic compound, triterpenoids, glycosides and absence of alkaloids, saponins, steroids and anthraquinone glycosides. Total phenolic content was almost double to the total flavonoid contents. Both these contents were found higher in the methano l extract than aqueous and hydroalcoholic extract.
Conclusively, isolated compounds hirtacoumaroflavonoside (HCF) and hirtaflavonoside- A (HFA) and extract as such could be a potential agent for treating diabetes and diabetic dyslipidemia. In addition, they have showed in-vitro enzyme inhibition. Moreover they demonstrated better safety profile. These compounds can be further taken up for the detailed pharmacokinetic (PK) study, pharmacokinetic (PK) and pharmacodynamic (PD) correlation and toxicological studies. If aforementioned experiments provide promising results, preclinical to clinical translation of isolated compounds hirtacoumaroflavonoside (HCF) and hirtaflavonoside-A (HFA) and extract in diabetes is possible.
Key words: Glibenclamide, Antihyperlipidemic, Euphorbia hirta, Streptozotocin.

Cite This Article:

Please cite this article in press Shailendra Kumar Gupta et al, Pharmacological evaluation of euphorbia hirta l. For diabetes and diabetic dyslipidemia, Indo Am. J. P. Sci, 2023; 10 (01).

Number of Downloads : 10

References:

1. Sachi Saharma, Manoj Kumar, Pharmacological evaluation of Euphorbia hirta L. for diabetes and diabetic dyslipdemia vol. 8 Issue 1January 2023
2. Muhammad Zeeshan Ali, Malik Hassan, Mehmud, , Abdul Malik, Pharmacological Evaluation of Euphorbia hirta, Fabonia Indica and Capparis Decidua and hyper tension through in-vivo and in –vitro- assays.
3. S. Kumar, R . Malhotra , D. Kumar, Antidiabetic and free radicles Scavenging potential of Euphorbia hirta flower extract.
4. Anup Kumar Mourya, Smriti Tripathi Zabir Ahmad, Ram Kumar Sahu, Antidiabetic and antihyperlipidemic effect of Euphorbia hirta in streptozotacin induced to diabetic rats.
5. Sunil Kumar , Rashmi, D. Kumar , Evaluation of antidiabetic activity of Euphorbia hoirta linn. In streptozotacin induced diabetic mice vol. 1(2), June, 2010
6. Vibha Rani, Anubhuti Gupta, Sanya Verma antidiabetic activity of Indian medicinal plant.
7. S. Subramanian, S. Bhubneswari, G. Prasath antidiabetic and antioxidant potentials of euphoria hirta leaves extract studied and streptozotocin induced experimental diabetes in rats . Issue:1st September 2011
8. Tahira Shamim, Mehmud Ahmed , Muhammad Muktar antihyperglycemic and hypolipidimic effects of mythanolic extract of euphorbia prostrator on alloxal induced diabetic rabbits. Issue August 2014
9. S. Pradeepa, S. Subramanian, B. Kaviyarasan Biochemical evaluation of antidiabetic properties of Pithecellobium dulce fruits studied in streptozotocin induced experimental diabetic rats.
10. S. Gupta, L. Azmi, P.K. Mohapatra, C.Rao Flavonoids from whole Plant of Euphorbia hirta and their Evaluation against Experimentally induced Gastroesophageal Reflux Disease in Rats ,Issue 2017
11. D. Katare, Effect of ethanolic extract of Euphorbia hirta on chronic diabetes mellitus and associated cardiorenal damage in rats, Issue 2018
12. Nasirzadeh Mr., Nourazar Ar Effect of Alcoholic Extract of Euphorbia cyparissias on Serum Glucose and Antioxidant Enzymes Level in Diabetic Male Rats , issue 2-014
13. Le Thi Bach , L. Dung, Nguyen Trong Tuan, N. Thanh THE PROTECTIVE EFFECT OF SOME EXTRACTS AND ISOLATED COMPOUNDS FROM EUPHORBIA HIRTA ON PANCREATIC β-CELLS MIN6 , Issue 2018
14. B. Bading Taika, M. Bouckandou, A. Souza, H.P. Bourobou Bourobou, L. MacKenzie and L. Lione, An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology, Journal of Ethnopharmacology,
15. https://doi.org/10.1016/j.jep.2017.12.036