Volume : 10, Issue : 03, March – 2023
Title:
19.EVALUATION OF METRONIDAZOLE TABLETS FORMULATED WITH DIFFERENT DISINTEGRANTS USING MOISTURE ACTIVATED DRY GRANULATION (MADG)
Authors :
*Ezegbe Chekwube Andrew, Ezegbe Amarachi Grace, Chime Amarachi Salome, Ugwu Calister Elochukwu, Boniface Christian Izuchukwu, Ugwuoke Kenneth Ejiofor , Chukwuemeka Chizoba Lorritaa, Onunkwo Godswill
Abstract :
Introduction: Metronidazole is a synthetic oral nitroimidazole antibiotic used in the treatment of infections caused by anaerobic bacteria and protozoa. It also has amebicidal and antiprotozoal properties.
Aim: The purpose of the study was to formulate and evaluate metronidazole tablets formulated with polymers (PVP and PEG) and maize starch as disintegrant using moisture activated dry granulation (MADG).
Method: Twenty-four (24) batches of metronidazole granules and tablets were prepared by moisture activated dry granulation. Metronidazole (200 mg), lactose and gelatin (1,2,4 and 8 %) were mixed, followed by continuous mixing. Prior to compression, micro-crystalline cellulose, disintegrants and magnesium stearate were added. The dried granules were passed via 1.0 mm sieve after which they were labelled and stored in an air tight container. All other batches were also similarly prepared.
Result: The result showed that the mean weight of the tablets ranged from 0.33 ± 0.01 to 0.35 ± 0.04 g. Tablet hardness ranged from 5.00 ± 0.85 to 6.36 ± 1.43. The results showed that batch 11 tablets had higher crushing strength than batch 24 with a significant difference. Table 2 shows the hardness test results and clearly indicates that the results of all the samples significantly differ from each other (p < 0.05). The tablet friability test ranged from 0.21 ± 0.17 for batch 24 and 0.60 ± 0.16 for batch 11. The formulated tablets showed average disintegration time ranges from 0.52 ± 0.01 to 14.03 ± 0.03. According to USP, the disintegration time must be in the range of 15 min for uncoated tablets, and 30 mins for film coated tablets
Conclusion: The study established that polyethylene glycol and polyvinyl pyrrolidone polymers had better dissolution profile than maize starch which has the best disintegration properties.
Keywords: Metronidazole, Moisture activated dry granulation, Disintegrants, Polymers.
Cite This Article:
Please cite this article in press Ezegbe Chekwube Andrew et al, Evaluation Of Metronidazole Tablets Formulated With Different Disintegrants Using Moisture Activated Dry Granulation (MADG).,Indo Am. J. P. Sci, 2023; 10(03).
Number of Downloads : 10
References:
1. Shilpa PC, Pradeep SP. Pharmaceutical excipients: A review. Int J Adv Pharm Biol Chem 2012;1:21-34.
2 Das AS, Das S, Samanta A. Formulation and evaluation of controlled release floating capsules of ciprofloxacin HCL. Der Pharm Sin 2013;4:72-5.
3. Chukwu A. Studies on detarium microcarpium gum II. Investigation as a prolonged release matrix for encapsulated chlorpheniramine maleate. STP Pharma Sci 1994;4:399-403.
4. Disanto AR. Bioavailability and bioequivalency testing in remington. Sci Pract Pharm 1995;19:606.
5. Eichie FE, Amalime AE. Evaluation of the binder effects of the gum mucilages of Cissus populinea sand Acacia senegal on the mechanical properties of paracetamol tablets. Afr J Biotechnol 2007;19:2208-11.
6. Emeje M, Isimi C, Kunle O. Effect of Grewia gum on the mechanical properties of paracetamol tablet formulations. Afr J Pharm Pharmacol 2007;2:1-6.
7. Ibezim EC, Ofoefule SI, Omeje EO, Onyishi VI, Odoh UE. The role of ginger starch as a binder in acetaminophen tablets. Sci Res Essay 2008;3:46-50.
8. Jani JK, Shah DP, Jain VC, Patel MJ, Vithalan DA. Evaluating mucilage from Aloe barbadensis Miller as a pharmaceutical excipient for sustained release matrix tablets. Pharm Technol 2007;31:90-8.
9. Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules 2008;13:1599-616.
10. Kotke MK, Chueh HR, Rodes CT. Comparison of disintegrant and binder activity of three corn starch products. Drug Dev Ind Pharm 1992;18:2207-23.
11. Prescott JK, Barnum RA. Powder flowability. Pharm Technol 2000;24:60-84.
12. Ankit Sharma, Pooja sethi, Dinesh pawar. “Granulation techniques and innovations”, Inventi Rapid: Pharmtech, Vol.10, 2011.
13. Aniruddha MR, Joseph BS. Use of a moist granulation technique to develop controlled-release dosage forms of acetaminophen. Drug Dev Ind Pharm 4 ; 27,337 -43, 2001.
14. . B.Venkateswara Reddy, K. Navaneetha, P. Sandeep. Improved tablet production by modified granulation techniques, International Journal of research in pharmacy and life sciences, 2(2), 224-235, 2014.
15 Das S, Roy D. Formulation and evaluation of beta-cyclodextrin complex tablets of ibuprofen. Int J Pharm Res Health Sci 2016;4:1022 4.
16. Nag D, Das S, Samanta A. Formulation and evaluation of immediate release tablet of isoniazid and pyridoxine hydrochloride. World J Parm Pharm Sci 2015;4:1726-40.
17 Haritha B. A review on evaluation of tablets. J Formul Sci Bioavailab 2017;1:2-3.
18. Das S, Samanta A, Dey HS. Formulation, in vitro release kinetics and stability interpretation of sustained release tablets of metformin hydrochloride. Int J Pharm Pharm Sci 2015;7:418-22.
19. Uzondu Akueyinwa Lovet, Okafo Sinodukoo and Eziuzo oe- Ob Christian. L. Modification of drug release profile of metronidazole tablet using co-precipitate of irvingia and egg albumin – A proven good technology. World J. Pharm Sci. 2015; 3(3): 588-595.
20 Kumar, Vijay & Reus-Medina, Maria & Yang, Dong. Preparation, characterization, and tabletting properties of a new cellulose-based pharmaceutical aid. International journal of pharmaceutics. 2002, 235. 129-40. 10.1016/S0378-5173(01)00995-4.
21. United States Pharmacopeia (2006). United States Pharmacopeial Convention Inc. Rockville.
22. Lavanya K, Senthil V, Rathi V. Pelletization technology: a quick review. International Journal of Pharmaceutical Sciences and Research. 2011 Jun 1;2(6):1337.
23. Noor, Sadia, et al. “Comparative in-vitro quality evaluation of some brands of Metronidazole tablet available in Bangladesh.”International Journal of Applied Research 3.7 (2017): 753-8.
24. United States Pharmacopeia National Formulary, the United States Pharmacopeial Convention. Inc., Rockville, MD, 2008.