23.Issue 03 march 23 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 10, Issue : 03, March – 2023

Title:

23.SOLID LIPID NANOPARTICLES: A REVIEW
‬

Authors :

Yerragopu Nagasurekha*, R Saravanan, Kole Shivakumar

Abstract :

Solid lipid nanoparticles (SLN) are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery and research. Due to their unique size dependent properties, lipid nanoparticles offer possibility to develop new therapeutics. The ability to incorporate drugs into nanocarriers offers a new prototype in drug delivery that could use for drug targeting. Hence solid lipid nanoparticles hold great promise for reaching the goal of controlled and site specific drug delivery and hence attracted wide attention of researchers. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. Appropriate analytical techniques for the characterization of SLN like photon correlation spectroscopy, scanning electron microscopy, differential scanning calorimetry are highlighted. Aspects of SLN route of administration and the in vivo fate of the carriers are also discussed.
Key words: Colloidal drug carriers, Homogenization, TEM, PCS, Biodistribution targeting.

Cite This Article:

Please cite this article in press Y.Naga Surekha et al, Solid Lipid Nanoparticles: A Review., Indo Am. J. P. Sci, 2023; 10 (03).

Number of Downloads : 10

References:

1. S. Mukherjee, S. Ray and R. S. Thakur, Ind. J. Pharm. Sci., 349-358 (2009). M. R. Mozafari, 41-50 (2006).
2. Rainer H. Muller, Karsten Mader and Sven Gohla, Eur. J. Pharm. Biopharm., 50(1), 161-177 (2000).
3. Wolfgang Mehnart and Karsten Mader, Adv. Drug. Deliv. Rev., 47, 165-196 (2001).
4. Houli Li, Xiaobin Zhao, Yukun Ma and Guangxi Zhai, Ling Bing Li and Hong Xiang, Lou. J. Cont. Release, 133, 238-244 (2009).
5. Melike Uner, Gulgun Yener, Int. J. Nanomedicine, 2(3), 289-300 (2007).
6. Annette Zur Mehlen, Cora Schwarz and Wolfgang Mehnart, Eur. J. Pharm. Biopharm., 45, 149-155 (1998).
7. Elena Ugazia, Roberta Cavalli and M. R. Gasco, Int. J. Pharm., 241, 341-344 (2002).
8. Indu Pal Kaur, Rohit Bhandari, Swati Bhandari and Kakkur. J. Cont. Rel., 127, 97-109 (2008).
9. Ghada Abdelbary and Rania H. Fahmy, AAPS Pharm. Sci. Tech., 10(1) (2009).
10. N. Al-Haj and A. Rasedee, Int. J. Pharmacol., 5(1), 90-93 (2009).
11. Dong Zhi Hou, Chang Sheng Xie, Kaijn Huang and Chang Hong Zhu, Biomaterials, 24, 1781-1785 (2003).
12. Alessandro Bargoni, Roberto Cavalla, Otto Caputo and M. R Gasco, Pharm. Res., 15(5), 745-750 (1998).
13. Milan Stuchlík and Stanislav Žák, Biomed, Papers, 145(2), 17-26 (2001).
14. C. Olbrich and R. H. Muller, Int. J. Pharm., 180, 31-39 (1999).
15. D. Schwarz, W. Mehnert, J. S. Lucks and R. H. Muller, J. Cont. Release, 30, 83-96 (1994).
16. Wei Liu, Meling Hu, Wehsuang Liu and Chengbin Xue, Huibi Xu, Int. J. Pharm., 364, 141-146 (2008).
17. Qing Zhi Lu, Aihua Yu, Yanwei Xi and Houli Li, Zhimei Song, Jing Cui and Fengliang Cao, Guangxi Zhai, Int. J. Pharm., 372, 191 – 198 (2009).
18. Yi Fan Luo, DaWei Chen, Li Xiang Ren and Xiu Li Zhao, Jing Qin, J. Cont. Release, 114, 53–59 (2006).
19. Rishi Paliwal, Shivani Rai, Bhuvaneshwar Vaidya, Kapil Khatri, Amit K. Goyal, Neeraj Mishra, Abhinav Mehta and Suresh P. Vyas, PhD. Nanomedicine, Nanotechnology, Biology and Medicine, 5(2), (2009) pp. 184-191.
20. Zhenghong Xu, Lingli Chen, Wangwen Gu and Yu Gao, Liping Lin, Zhiwen Zhang and Yong Xi, Yaping Li, Biomaterials, 30, 226 (2009).
21. Rathapon Asasutjarit, Sven – Iver Lorenzen, Sunee Sirivichayakul and Kiat Ruxrungtham, Uracha Ruktanonchi and Garnpimol C. Ritthidej, Pharm. Res., 24(6), 1098 – 1107 (2007).
22. Carsten Rudolph, Ulrike Schillinger, Aurora Ortiz and Kerstin Tabatt, Christian Plank, Rainer H. Müller and Joseph Rosenecker, Pharm. Research, 21(9), 1662-1669 (2004).
23. Robhash Kusam Subedia, Keon Wook Kanga and Hoo-Kyun Choi, Eur. J. Pharm. Sci., 37(3-4), 508- 513 (2009).
24. Suresh Gande, Kopparam Manjunath, Vobalaboina Venkateswarlu and Vemula Satyanarayana, AAPS Pharm. Sci. Tech., 8(1), Article 24 (2007).
25. Nagi A. Alhaj, Rasedee Abdullah, Siddig Ibrahim and Ahmed Bustamenn, Amer. J. Pharmacology and Toxicology, 3(3), 219 – 224 (2008).
26. Michael D. Triplett, E. James, F. Rathman, J. Nanopart Res., 11, 601–614 (2009).
27. Yung-Chih Kuo and Hung-Hao Chen, Int. J. Pharm., 365, 206-213 (2009).
28. K. Vivek, Harivardhan Reddy and Ramachandra S. R. Murthy, AAPS Pharm. Sci. Tech., 8(4), Article 83 (2007).
29. S. Mukherjee, Subhabrata Ray and R. S. Thakur, Pak. J. Pharm. Sci., 22(2), 131-138 (2009).
30. E. Q. Hu, H. Yuan, H. H. Zhang and M. Fang, Int. J. Pharm., 239, 121-128 (2002).
31. Niladi Chattopadhyay, Jason Zastre, Ho-Lun Wong and Xiao Yu Wu, Reina Bendayan, Pharm. Research, 25(10), (2008).
32. Katja Jores, Annekathrin Haberland, Siegfried Wartewig and Karsten Mader, Wolfgang Mehnart, Pharm. Res., 22(11), 1887-1879 (2005).
33. Bin Lua, Su-Bin Xionga, Hong Yanga and Xiao-Dong Yina, Ruo- Bing Chaoa, Eur. J. Pharmaceutical Sci., 28(1-2), 86-95 (2006).
34. Meyer E Heinzelmann and Wiesendanger R. Springer Verlogg, 99-149 (1992).
35. Pallavi V. Pople and Kamalinder K. Singh, AAPS Pharm. Sci. Tech., 7(4), Article 91 (2006).
36. Lang Sc, Lu L. F, Cai Y and Zhu J. B, Liang BW and Yang CZ, J. Controlled Release, 59, 299-307 (1999).
37. Biswajit Basu, Kevin Garala, Ravi Bhalodia and Bhavik Joshi, Kuldeep Mehta, J. Pharm. Res., 3(1),84-92 (2010).
38. Wolfgang Mehnert and Karsten Mader, Adv. Drug Delivery Rev., 47, 165-196 (2001).
39. Vivek Ranjan Sinha, Saurabh Srivastava and Honey Goel, Int. J. Adv. Pharm. Sci., 1, 212-238 (2010).
40. Melike Uner, Gulgun Yener, Int. J. Nanomedicine, 2(3), 289-300 (2007).
41. Karsten Mader, 187-212.
42. Antonio J. Almeida and Eliana Souto, Adv. Drug Delivery Rev., 59, 478-490 (2007).
43. Manisha Misra, P. Muthuprasanna and K. Surya Prabha, Int. J. Pharm. Tech. Res., 1(4), 1354-1365 (2009).
44. Malgorzata Smola, Thierry Vandamme and Adam Sokolowski, Int. J. Nanomedicine, 1-9 (2008).
45. Jessy Shaji and Vinay Jain, Int. J. Pharmacy and Pharm. Sci., 2(3), 8-17 (2010).
46. Biswajit Basu, Kevin Garala, Ravi Bhalodia and Bhavik Joshi, Kuldeep Mehta, J. Pharm. Res., 3(1), 84-92 (2008).
47. Suphiya Pareev and Sanjeeh K. Sahoo, Nanomedicine, Nanotechnology, Biology and Medicine, xx. xxx-xxx (2011).
48. S. Mukherjee, S. Ray and R. S. Thakur, Ind. J. Pharm. Sci., 349-358 (2009).
49. Hania Degobert, Adv. Drug Delivery Reviews, 1688-1713 (2006).
50. Sven Gohla, Eur. J. Pharm. Biopharm., 50, 161-177 (2000).
51. S. P. Vyas and R. K. Khar, Controlled Drug Delivery – Concepts and Advances, First Edition, Vallabh Prakashan (2002) pp. 38-50.
52. N. K. Jain, Controlled and Novel Drug Delivery, First Edition, CBS Publishers and Distributors, (1997) pp. 3-28.
53. Y. W. Chien, Novel Drug Delivery, 2nd Edition, (2005) pp. 1-5.
54. S. P. Vyas and R. K. Khar, Targeted Drug Delivery System, 112-146 (2000).
55. Joseph Robinson and Vincent H. L. Lee, Controlled Drug Delivery – Fundamentals and Applications, 2nd Edition, 4-33.
56. Shuyu Xie, Luyan Zhu, Zhao Dong and Yan Wang, Colloids and Surfaces B: Biointerfaces, 83, 382- 387 (2011).
57. Vinay Kumar V, AAPS Pharm. Sci. Tech., Feb, 42-49 (2010).
58. Maria Luisa Bondi, Antonina Azzolina and Melchiorre Cervello, Current Nanoscience, 5, 39-44 (2009).
59. Waree Tiyaboonchai, Watcharaphorn Tungpradit and Ponyupa Plianbangchang, Int. J. Pharm., 337, 299-306 (2007).
60. Ziyaur Rahman, Ahmed S. Zidan and Mansoor K. Khan, Eur. J. Pharm. Biopharm., 76, 127-137 (2010).
61. Pallavi V. Pople and Kamalinder K. Singh, AAPS Pharm. Sci. Tech., 7(4), 91 (2006).
62. Nagi A. ALHaj, Rasedee Abdullah, Siddig Ibrahim and Ahmad Bustamam, Amer. J. Pharmacol. Toxicol., 3(3), 219-224 (2008).
63. Franscesco Lai, Sylvia A. Wissing and Anna M. Fadda, AAPS Pharm. Sci. Tech., 7(1), 2 (2006).
64. Alaa Eldeen B. Yassin, Md Khalid Anwer and Ibrahim A. Alsarra, Int. J. Medical Sci., 7(6), 398-408 (2010).
65. L. Harivardhan Reddy and R. S. R. Murthy, AAPS Pharm. Sci. Tech., 6(2), 24 (2005).
66. Ambikanandan Misra and Mayor Kalariya, Drug Delivery Technol., 4(8), (2004).
67. K. Vivek, Harivardhan Reddy and Ramachandra S.R. Murthy, AAPS Pharm. Sci. Tech., 8(4), 83 (2007).
68. Gande Suredh, Kopparam Manjunath, Vobalaboina Venkateswarlu and Vemula Styanarayana, AAPS Pharm. Sci. Tech., 8(1), 24 (2007).
69. T. Helgason, T. S. Awas, K. Kristbergsson and J. Weiss, J. Colloid, Interface Science, 334, 75-81 (2009).
70. Zaida Urban-morlan, Adriana Ganem- rondero and David Quintanar-guerrero, Int. J. Nanomedicine, 5, 611-620 (2010).
71. Venishetty Vinay Kumar, Durairaj Chandrasekar and Prakash Vamanrao Diwan, Int. J. Pharm., 335, 167-175 (2007).
72. Robhash Kusam Subedi, Keon Wook Kang and Hoo-Kyun Choi, Eur. J. Pharm. Sci., 37, 508-513 (2009).
73. R. C. Doijad, F. V. Manvi and N. V. Deahmukh, Int. J. Pharm. Sci., 203-207 (2008).
74. M. Sedef Erdal, Sevgi Gungor and Ahmet Araman, Acta Pharmaceut. Sci., 51, 203-210.
75. Qing-Yu Xiang, Tao Gong and Yuan Huang, Arch. Pharm. Res., 30(4), 519-525.
76. Vanna Sanna, Nathalie Kirscvink and Brigitte Evrard, AAPS Pharm. Sci. Tech., 5(2), 27 (2003).
77. Mangesh R. Bhalekar, Vasha Pokhakar, Nilam Patil and Nilkanh Patil, AAPS Pharm. Sci. Tech., 10(1)
(2009).
78. Matteo Mazzena, Santo Scalia and Daniela Traini, The AAPS Jounal, 11(4) (2009).
79. Behzad Sharif Makhmal Zadeh and Fakher Rahim, Int. J. Res. Pharm. Sci., 1(4), 466-472 (2010).
80. Qingzhi Lv, Aihua Yu and Houli Li, Int. J. Pharm., 372, 191-198 (2009).
81. N. P. Aditya, S. Patankar, B. Madhusudhan, Eur. J. Pharm. Sci., 40, 448 (2010).
82. Yingchao Li. Lei Dong, Xinming Chang and Hui Xue, Int. J. Biological Macromolecules, 38, 296-299 (2006).
83. Srinivas Ganta, William A. Denny and Sanjay Garg, Int. J. Pharm., 367, 187-194 (2009).
84. Vobalaboina Venkateswarlu and Kopparam Manjunath, J. Controlled Rel., 95, 627-638 (2004).
85. Vanna Sanna, Giuseppe Caria and Alberto Mariani, Powder Technol., 201, 32-36 (2010).
86. Ander Estella-Hermoso de Mendoza, Marta Rayo and Faustino Mollinedo, Eur. J. Pharm. Biopharm.,
68, 207-213 (2008).
87. A. A. Attama, B. C. Schicke, T. Paepenmu¨ller and C. C. Mu¨ller-Goymann, Eur. J. Pharm. Biopharm.,
67, 48-57 (2007).
88. Tzu-Hui Wu, Feng-Lin Yen and Thau-Ming Cham, Int. J. Pharm., 346(1-2), 160-168 (2008).
89. F. Q. Hu, H. Yuan, H. H. Zhang and M. Fang, Int. J. Pharm., 239(1-2), 121-128 (2002).
90. S. Tamizhrasi, A. Shukla, T. Shivkumar and V. Rathi, Int. J. Pharm. Tech. Research, 1(3), 411-415, July-Sept (2009).
91. Apurva R. Patel, Tanise Jackson, Prasad N. V. Tata and Mandip Singh, J. Cont. Rel., 144, 233-241 (2010).
92. Soheila Kheradmandnia and Ebrahim Vasheghani-Farahani, Nanomedicine: Nanotechnol., Biol., Med., 6, 753-759 (2010).
93. M. R. Aji Alex, A. J. Chacko, S. Jose and E. B. Souto, Eur. J. Pharmaceut. Sci., 42, 11-18 (2011).
94. Mi-Kyung Lee, Soo-Jeong Lim and Chong-Kook Kim, Biomater., 28, 2137-2146 (2007).
95. Jia-You Fang, Chia-Lang Fang, Chi-Hsien Liu and Yu-Han Su, Eur. J. Pharm. Biopharm., 70, 633- 640 (2008).
96. Guihua Huang, Na Zhang, Xiuli Bi and Mingjin Dou, Int. J. Pharm., 355, 314-320 (2008).
97. Hazem Ali, Amit B. Shirode, Paul W. Sylvester and Sami Nazzal, Colloids and Surfaces, A: Physicochem. Eng. Aspects, 353, 43-51 (2010).
98. Kumar A. Shah, Abhijit A. Date, Medha D. Josh and Vandana B. Patravale, Int. J. Pharm., 345, 163- 171 (2007).
99. Jing Dong, Yajiang Yang, Xiangliang Yang and Huibi Xu, Eur. Polymer J., 41, 375-382 (2005).
100. Praveen Kumar Gupta, J. K. Pandit, Ajay Kumar and Pallavi Swaroop, Sanjiv gupta, T. Ph. Res.,3, 117-138 (2010).
101. P. Ahlin, J. Kristl, A. Kristl and F. Vrecer, Int. J. Pharm., 239, 113–120 (2002).