10.Issue 05 may 23 - INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES

Volume : 10, Issue : 05, May – 2023

Title:

10.INVESTIGATION OF ANTICANCER ACTIVITY ON CURCUMIN DENDRIMERIC NANOFORMULATION
‬

Authors :

Poonam Yadav , Sarika Chaturvedi, Purnima Tiwari , Shilpi Chaturvedi

Abstract :

Curcumin (diferuloylmethane) is a polyphenol derivedfrom the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer. The anticancer potential of curcumin stems from its ability to suppress proliferation of a wide variety of tumor cells, down-regulatetranscription factors NF-κB, AP-1 and Egr-1; down-regulate theexpression of COX2, LOX, NOS, MMP-9, uPA, TNF,chemokines, cell surface adhesion molecules and cyclin D1;down-regulate growth factor receptors (such as EGFR andHER2); and inhibit the activity of c-Jun N-terminal kinase,protein tyrosine kinases and protein serine/threonine kinases.
One draw-back holding curcumin back is its insolublility in water and therefore has poor absorption and subsequently poor bioavailability.
Dendrimer, being well defined and highly branched macromolecule, their multifunctionality and specific shape have been recognized as powerful tool in drug delivery. Polyamidation (PAMAM) dendrimers consist of core dendr-termini (i.e. DAB-dendr -(NH2)64) is a diaminobutanecore dendritic poly(propylene mine) having 64 primary amine termini, also named as DAB-dendr -(PA)64, where PA stands for polyamine, and its repeating units and terminal groups potent for interaction of oppositely charged component and produces surfactant like effects by forming a nanoparticles for drug delivery. In the context of drug delivery, the use of fatty acids as permeation enhancer limits the metabolism of drug in liver when administered orally and allowed for plasma binding in blood readily. The application f this study could be sustained for oral delivery and improved absorption through gastrointestinal tract for overall enhancement in therapeutic efficacy.
Based on these reports, the present study is designed to overcome pharmacokinetic drawbacks by conjugating with dendrimer and understanding there physicochemical properties of curcumin/dendrimer/fatty acids complex system and to evaluate its suitability for sustained drug release, which is further allowed for oral drug delivery for screening as potent anticancer agents by using in vitro and in vivo model.

Cite This Article:

Please cite this article in press Poonam Yadavet al, Investigation Of Anticancer Activity On Curcumin Dendrimeric Nano formulation.,Indo Am. J. P. Sci, 2023; 10 (05).

Number of Downloads : 10

References:

1. Aggarwal BB, Sundaram C, Malani N, Ichikawa H., 2007. Curcumin: the Indian solid gold. Adv Exp Med Biol, 595, pp 1-75.
2. Aggarwal, B.B., Shishodia, S., Takada, Y., Banerjee, S., Newman, R.A., Bueso-Ramos C.E., and Price, J.E., 2005. Curcumin suppresses the paclitaxel-induced nuclear factorkappaBpathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nudemice. Clinical Cancer Research, 11, pp. 7490-7498.
1. 3.Aggarwal,S. , Takada, Y. , singh, S., Myers, J.N., and Aggarwal, B.B., 2004.Inhibition ofgrowth and survival of human head and neck squamous cell carcinoma cells by curcumin viamodulation of nuclear factor kappa B signaling,International journal of cancer, 111, pp 679-692.
2. Akiskal ,K.K., Savino,M.,Akiskal,H.S. ,2005. Temperament profiles in physicians,lowyers, managers, industrialists, architects, journalists, and artists; a study in psychiatric outpatients. Journal of Affective disorders 85, pp 201-206.
3. Anand, P.; Kunnumakkara, A. B.; Newman, R. A.; Aggarwal, B. B.,2007. Bioavailabilityof curcumin: problems and promises. Molecular Pharmaceutics 4 (6), pp 807–818.
4. Ansari;S.H.;Islam Farha .,and Sameem Mohd., 2012.Influence of nanotechnology onherbal drug, 3(3), pp 142-146.
5. B.Bharat., Aggarwal, Kumar Anushree and C. Bharti Alok., Anticancer potential ofcurcumin ; preclinical and clinlcal studies; 23:363-398(2003).
6. Bhanot, A., R. Sharma, S. Singh and M.N. Noolvi, 2012. Antioxidant activity of variousfractions of ethanol extract on Aerva lanata Linn. Inventi Impact: Planta Act, pp: 1-5
7. Bond JH: Colorectal cancer update: prevention, screening, treatment,andsurveillance for high- risk groups. Med Clin North Am 84, 1163–1182,2000.
8. Brouk B. Plants Consumed by Man. New York, NY: Academic Press, 1975.
9. 11.C. Moorthi, C. Senthil kumar , K.Kathiresan; “Synergistic Anti-cancer Activity ofcurcumin and bioenhancers combination against various cancer cell line” volume 6, suppl 2,2014 ISSN- 0975-1491.
10. D.Lagnoux., T. Darbre., M.L.Schmitz., J.L.Revmond.,”Inhibition of mitosis byglycopeptides dendrimer conjugates of calchicine, 2005 jun 20;11(13):3941-50.
11. 13.Debnath S. Soloum D. , Dolai S. , Sunc, Averick S. ,Raja K., And Fata J. F. , 2013.Dendrimer curcumin conjugate
12. 14.Ferlay J, Soerjomataram I, Ervik M, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM,Forman D, Bray, F. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide:IARC CancerBase No. 11 [Internet]. Lyon, France: International Agency for Research onCancer; 2013 Mar 1;132(5):1133-45.
13. J. Cao., H.Zhang., Y.Wang., J.Yang., F. Jiang; “Investigation on the interaction behaviorbetween curcumin and PAMAM dendrimer by spectral and docking studies; 2013 may; 108:251-5.
14. J.Drbohlavova., J.Chomoucka., V.Adam, M.Ryvolova ., T.Echschlager., J.Hubalek.,R.Kizek “Nanocarriers for anticancer drugs –new trends in nanomedicine” .2010 sep 1.18
15. (17):6589-97.
16. Jabara, A. G. ,Marks , G. N. , Summers, J. E. , Anderson, P. S., Br. J. Cancer 1979.
17. Jemal A, Thomas A, Murray T, Thun M. Cancer statistics, 2002. CA Cancer J Clin.2002;52: 23–47.
18. K.Adams Brian ,M. Ferstl Eva, C.Davis Matthew, Herold Marike ,Kurtkaya serdar,F.Camalier Richard , G. Holligshead Melinda , Kaur Gurmeet, A . Sausville Edward , R.
19. Rickles Frederick , P. Snyder James , C. Liotta Dennis and Shoji mamorus “Synthesis andbiological evaluation of novel curcumin analogs on anticancer and anti-angiogenesis agents“.,12(2004) page no.3871-3883
20. 22.Kiranmayi.Gali.; G. Ramakrishnan., R. Kothai., B. JaykarDepartment”in-vitro Anti-Cancer activity of Methanolicextract of leaves of Argemone mexicana Linn”;Vol.3,
21. No.3,pp1329-1333, July-Sept 2011.
22. 23. Kita, Tomoko; Imai, Shinsuke; Sawada, Hiroshi; Kumagai, Hidehiko; Seto, Haruo(2008). “The Biosynthetic Pathway of Curcuminoid in Turmeric (Curcuma longa) as
23. Revealed by 13CLabeled Precursors”. Bioscience, Biotechnology, and Biochemistry 72 (7):1789.