Volume : 10, Issue : 05, May – 2023
Title:
12.ROLE OF VITAMIN D IN HYPERTHYROIDISM AND HYPOTHYROIDISM
Authors :
Sultan Musayfir M Aljuaid, Sultan saud abdulaziz asali
Abstract :
The fundamental function of vitamin D is to keep the balance of calcium and phosphorus, which protects the health of bones. According to recent research, vitamin D may also play a function in several non-skeletal conditions, including endocrine diseases like type 1 and type 2 diabetes, adrenal disorders, and polycystic ovarian syndrome. Inadequate vitamin D levels are linked to thyroid conditions such as Hashimoto’s thyroiditis. Similarly, it was found that patients with newly diagnosed Graves disease had lower concentrations of 25-hydroxyvitamin D. Thyroid cancer has been linked to faulty vitamin D signalling, according to research. Studies on vitamin D supplementation in thyroid disease patients are carried out. Randomized controlled trials are required to shed light on the effectiveness and safety of vitamin D as a therapeutic tool for this dysfunction, even if observational studies suggest a positive role for it in the therapy of thyroid disease.
Aim of the study:
This review will describe the effects of vitamin D supplementation and concentrate on the role of vitamin D in thyroid diseases such as hyperthyroidism and hypothyroidism.
Methodology:
The literature review is comprehensive research on the role of vitamin D in thyroid disease management. PUBMED is the search engine that was the mainly database used for the search process, and articles were collected from 1990 to 2022. The term used in the search were: Vitamin D, thyroid disorder, hyperthyroidism, hypothyroidism.
Conclusion:
Although several findings support the role of vitamin D in the pathogenesis of thyroid diseases and the strong association in the treatment plan, there is a lack of evidence, and a dearth of intervention studies and clinical trials suggest that vitamin D insufficiency or deficiency may be associated with increased risk of thyroid disease. Therefore, no guidelines or recommendations are currently available for or against recommending vitamin D by the Endocrine Society.
Keywords: Vitamin D, thyroid disorder, hyperthyroidism, hypothyroidism, etc.
Cite This Article:
Please cite this article in press Sultan Musayfir M Aljuaid et al, Role Of Vitamin D In Hyperthyroidism And Hypothyroidism, Indo Am. J. P. Sci, 2023; 10 (05).
Number of Downloads : 10
References:
1. Adams, J.S. and M. Hewison, Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Clin Pract Endocrinol Metab, 2008. 4(2): p. 80-90.
2. Menconi, F., C. Marcocci, and M. Marinò, Diagnosis and classification of Graves’ disease. Autoimmun Rev, 2014. 13(4-5): p. 398-402.
3. Bikle, D., Nonclassic actions of vitamin D. J Clin Endocrinol Metab, 2009. 94(1): p. 26-34.
4. Mazokopakis, E.E., et al., Is vitamin D related to pathogenesis and treatment of Hashimoto’s thyroiditis? Hell J Nucl Med, 2015. 18(3): p. 222-7.
5. Wacker, M. and M.F. Holick, Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients, 2013. 5(1): p. 111-48.
6. Moon, S., et al., Associations between Hashimoto Thyroiditis and Clinical Outcomes of Papillary Thyroid Cancer: A Meta-Analysis of Observational Studies. Endocrinol Metab (Seoul), 2018. 33(4): p. 473-484.
7. Kust, D. and N. Matesa, The impact of familial predisposition on the development of Hashimoto’s thyroiditis. Acta Clin Belg, 2020. 75(2): p. 104-108.
8. Krysiak, R., W. Szkróbka, and B. Okopień, The Effect of Vitamin D on Thyroid Autoimmunity in Levothyroxine-Treated Women with Hashimoto’s Thyroiditis and Normal Vitamin D Status. Exp Clin Endocrinol Diabetes, 2017. 125(4): p. 229-233.
9. Goswami, R., et al., Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. British Journal of Nutrition, 2009. 102(3): p. 382-386.
10. Unal, A.D., et al., Clinical immunologyVitamin D deficiency is related to thyroid antibodies in autoimmune thyroiditis. Central European Journal of Immunology, 2014. 39(4): p. 493-497.
11. Wang, X., et al., Low Serum Vitamin D Is Associated with Anti-Thyroid-Globulin Antibody in Female Individuals. Int J Endocrinol, 2015. 2015: p. 285290.
12. ElRawi, H.A., et al., Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. J Thyroid Res, 2019. 2019: p. 3583250.
13. Shin, D.Y., et al., Low serum vitamin D is associated with anti-thyroid peroxidase antibody in autoimmune thyroiditis. Yonsei Med J, 2014. 55(2): p. 476-81.
14. Simsek, Y., et al., Effects of Vitamin D treatment on thyroid autoimmunity. J Res Med Sci, 2016. 21: p. 85.
15. Krysiak, R., K. Kowalcze, and B. Okopień, Selenomethionine potentiates the impact of vitamin D on thyroid autoimmunity in euthyroid women with Hashimoto’s thyroiditis and low vitamin D status. Pharmacological Reports, 2019. 71(2): p. 367-373.
16. Sadeghi, K., et al., Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol, 2006. 36(2): p. 361-70.
17. Yasuda, T., et al., Serum vitamin D levels are decreased in patients without remission of Graves’ disease. Endocrine, 2013. 43(1): p. 230-232.
18. Sheriba, N.A., et al., Effect of vitamin D3 in treating hyperthyroidism in patients with graves’ disease. The Egyptian Journal of Internal Medicine, 2017. 29(2): p. 64-70.
19. Cho, Y.Y. and Y.J. Chung, Vitamin D supplementation does not prevent the recurrence of Graves’ disease. Scientific Reports, 2020. 10(1).
20. Talaei, A., F. Ghorbani, and Z. Asemi, The Effects of Vitamin D Supplementation on Thyroid Function in Hypothyroid Patients: A Randomized, Double-blind, Placebo-controlled Trial. Indian J Endocrinol Metab, 2018. 22(5): p. 584-588.
21. Holick, M.F., et al., Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab, 2011. 96(7): p. 1911-30.
22. Ashok, T., et al., Relationship Between Vitamin D and Thyroid: An Enigma. Cureus, 2022. 14(1): p. e21069.
23. Agmon-Levin, N., et al., Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol, 2013. 45(2): p. 256-66.
24. Fournier, C., et al., In vivo beneficial effects of cyclosporin A and 1,25-dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol, 1990. 54(1): p. 53-63.
25. Chen, W., H. Lin, and M. Wang, Immune intervention effects on the induction of experimental autoimmune thyroiditis. J Huazhong Univ Sci Technolog Med Sci, 2002. 22(4): p. 343-5, 354.