Volume : 10, Issue : 05, May – 2023
20.TO DESIGN AND DEVELOPMENT NOVEL EFFERVESCENT ANTIMICROBIAL MOUTHWASH
Mayuri Ashok Borkar, Yograj Mahajan, Burhanuddin Mohammad Husain
Plaque control is utmost essential for the suppression of gingivitis, dental caries, and halitosis-causing microorganisms. The most commonly used tool in the treatment of supragingival plaque are the tooth brushing either mechanical or electrical, dental floss, or interdental brushing. Other means of plaque control are chemical therapeutic agents such as mouthwashes, sprays, chewing gums and varnishes; aid in an effective home care. Nevertheless, mouthwashes have been accepted as the simplest and easiest mode of oral hygiene aid.This could be the main mode of oral cleansing in medically compromised patients and elderly where adequate oral hygiene maintenance could be a major concern. Chlorhexidine (CHX) has been the most widely used mouthwash and is considered as the gold standard in dental practice for about three decades, but not without certain disadvantages such as taste perturbation, tooth discoloration, oral ulcerations, unilateral, or bilateral parotid swelling. Considering these drawback of CHX mouthwash, alternative antiplaque agents have been developed in the recent years with the use of herbal products. Herbs have been the main source of medications since the ancient times of Charaka and Sushruta and have conquered the confidence of the people of Asia. Naturally available herbs such as tulsi, triphala, neem, honey, ajwain, turmeric, Zingiber Officinalis, etc., have been commonly used either alone or in combination as safe and effective antibacterial agents
KEYWORDS- Effervescent, Zingiber Officinale, Antimicrobial, Mouthwash.
Cite This Article:
Please cite this article in press Mayuri Ashok Borkar et al, To Design And Development Novel Effervescent Antimicrobial Mouthwash., Indo Am. J. P. Sci, 2023; 10 (05).
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1. Dr. Sandip .R. Pawar Mr. Gopal Jagannath Ahire, Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh Formulation Development of Mouthwash. © 2022 IJRAR May 2022, Volume 9, Issue 2
2. Mr. Gopal Jagannath Ahire, Dr. Sandip .R. Pawar Ahire, Dr. Bharat .V. Jain, Mr. Tanveer .Y. Shaikh Review of Mouthwash. © 2022 IJRAR may 2022, Volume 9, Issue 2
3. Atanasov AG, Waltenberger B, Pferschy-Wenzig EM, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv 2015;33:1582-614.
4. Chan EW, Wong SK. Phytochemistry and pharmacology of ornamental gingers, Hedychium coronarium and Alpinia purpurata: A review. J Integr Med 2015;13:368-79.
5. Bhakru HK. Ginger. Herbs that Heal. Natural Remedies for Good Health. 1st ed. New Delhi: Orient Paperbacks Publishers, A Division of Vision Books Pvt., Ltd.; 2008. p. 91.
6. Bode AM, Dong Z. The amazing and mighty ginger. In: Benzie IF, Wachtel-Galor S, editors. Herbal Medicine: Biomolecular and Clinical Aspects. 2nd ed. Ch. 7. Boca Raton, FL: CRC Press/Taylor & Francis; 2011.
7. Jung HW, Yoon CH, Park KM, Han HS, Park YK. Hexane fraction of Zingiberis Rhizoma crudus extract inhibits the production of nitric oxide and proinflammatory cytokines in LPS-stimulated BV2 microglial cells via the NF kappa B pathway. Food Chem Toxicol 2009;47:1190-7.
8. Kiuchi F, Iwakami S, Shibuya M, Hanaoka F, Sankawa U. Inhibition of prostaglandin and leukotriene biosynthesis by gingerols and diarylheptanoids. Chem Pharm Bull (Tokyo) 1992;40:387-91.
9. Aktan F, Henness S, Tran VH, Duke CC, Roufogalis BD, Ammit AJ. Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity. Planta Med 2006;72:727-34.
10. Srivastava KC, Mustafa T. Ginger (Zingiber officinale) in rheumatism and musculoskeletal disorders. Med Hypotheses 1992;39:342-8.
11. Guo J, Wu H, Du L, Zhang W, Yang J. Comparative antioxidant properties of some gingerols and Shagaols and the relationship of their contents with the antioxidant potencies of fresh and dried ginger (Gingiber officinale Roscoe). J Agric Sci Technol 2014;16:1063-72.
12. Shirin Adel PR, Prakash J. Chemical composition and antioxidant properties of ginger root (Zingiber officinale). J Med Plants Res 2010;4:2674-9.
13. Rahmani AH, Shabrmi FM, Aly SM. Active ingredients of ginger as potential candidates in the prevention and treatment of diseases via modulation of biological activities. Int J Physiol Pathophysiol Pharmacol 2014;6:125-36.
14. Kim SO, Kundu JK, Shin YK, Park JH, Cho MH, Kim TY, et al. gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 2005;24:2558-67.
15. Lee HS, Seo EY, Kang NE, Kim WK. -gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. J Nutr Biochem 2008;19:313-9.
16. Giriraju A, Yunus GY. Assessment of antimicrobial potential of 10% ginger extract against Streptococcus mutans, Candida albicans, and Enterococcus faecalis: An in vitro study. Indian J Dent Res 2013;24:397-400.
17. Auta KI, Galadima AA, Bassey JU, Olowoniyi OD, Moses OO, Yako AB. Antimicrobial properties of the Ethanolic extracts of Zingiber officinale (Ginger) on Escherichia coli and Pseudomonas
18. Eke, P. I.; Genco, R. J. CDC Periodontal Disease Surveillance Project: Background, Objectives, and Progress Report. J. Periodontol.2007, 78 (7 Suppl.), 1366–1371.
(https://www.healthypeople.gov.(access may 18,2016).
19. Thornton, G. Healthy People 2020 : Current Status and Future Direction Overview of Presentation,National Oral Health Conference, St. Louis, Missori.