Volume : 10, Issue : 05, May – 2023
Title:
27.FORMULATION AND EVALUATION OF GASTRO RETENTIVE FLOATING TABLET USING RIVASTIGMINE TARTRATE
Authors :
Hemangi P. Vaishnav*, Nisahn N. Bobade, Shrikant D. Pande
Abstract :
The present investigation was a successful attempt to develop gastro retentive floating tablet of Rivastigmine Tartrate in order to improve controlled release of drug. The formulation was effectively prepared using biocompatible polymer HPMC K4M and sodium alginate chosen in appropriate concentration with the drug. The gastro retentive floating tablet was preapared by direct compression method by applying 32 factorial designs. HPMC K4M (X1) and Sodium Alginate (X2) were selected as independent variables, and nine formulations were prepared in accordance with the experimental design. The prepared tablet was evaluated for different parameter such as wight variation, hardness, friability, floating time, drug content, in vitro dissoluation, swelling index and Dissolution data were analyse for kinetic model to study kinetic release of drug. From the evaluation of floating tablet of rivastigmine tartrate, F6 batch shown results were within limits and % CDR (98.559 ± 0.197) and buoyant up to 12 hours. Therefor, batch F6 was concluded as optimized formulation that could release drug in stomach at controlled release manner and prove to be potential candidate for safe and effective formulation for prolonged period of time.
Keywords: Rivastigmine tartrate, floating tablet, gastro-retentive, 32 factorial designs, Anti’alzheimer, dementia
Cite This Article:
Please cite this article in press Hemangi P. Vaishnav et al, Formulation And Evaluation Of Gastro Retentive Floating Tablet Using Rivastigmine Tartrate., Indo Am. J. P. Sci, 2023; 10 (05).
Number of Downloads : 10
References:
1. Lodh H, Sheeba FR, Chourasia PK, Pardhe HA, Pallavi N. Floating drug delivery system: A brief review. Asian Journal of Pharmacy and Technology. 2020 Nov 18;10(4):255-64.
2. Jain N. K., Advances in controlled and novel drug delivery. New Delhi: CBS publisher and distributors. 2008; 4: 11- 21.
3. Raza M, Jayswal MG, Ahmed A, Majaz Q, Khan GJ. REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM.
4. Rivastigmine tartrate [Internet]. Trc-canada.com. 2019 [cited 31 March 2019]. Available from: https://www.trc-canada.com/prod-img/MSDS/R541000MSDS.pdf
5. Jadi RK, Bomma R, Sellappan V. Development of a new single unit dosage form of propranolol HCl extended release non-effervescent floating matrix tablets: In vitro and in vivo evaluation. Journal of Applied Pharmaceutical Science. 2016 May 28;6(5):112-8.
6. Jadi RK, Bomma R, Sellappan V. Development of a new single unit dosage form of propranolol HCl extended release non-effervescent floating matrix tablets: In vitro and in vivo evaluation. Journal of Applied Pharmaceutical Science. 2016 May 28;6(5):112-8.
7. Chatwal RG, Anand KS. Instrumental methods of chemical analysis. 5th ed. Mumbai: Himalaya Publishing House; 2014.
8. Banker, Gilbert S. “The theory and practice of industrial pharmacy”. Vol. 1. Edited by Leon Lachman, Herbert A. Lieberman, and Joseph L. Kanig. Lea Febiger, Philadelphia, (1970): 1531-1531.
9. Kukati L, Chittimalli K, Shaik NB. Formulation and evaluation of floating tablets of cefpodoxime proxetil. Journal of scientific research. 2014 Aug 26;6(3):563-79.
10. Shilpa BC, Vishnu P, Babu KN, Rao UK, Sai S, Saravani T. A brief review on floating drug delivery system. S Pac J Pharm Bio Sci. 2014;2:137-53.
11. Mayavanshi AV, Gajjar SS. Floating drug delivery systems to increase gastric retention of drugs: A Review. Research Journal of Pharmacy and Technology. 2008 Oct;1(4):345-8.
12. Sutar FY, Gangurde AB, Patil DM. A Scientific Review On: Floating Drug Delivery System (FDDS). IJPRS. 2014;3(3):297-314.
13. Patel SS, Ray S, Thakur RS. Formulation and evaluation of floating drug delivery system containing clarithromycin for Helicobacter pylori. Acta Pol Pharm. 2006 Jan1;63(1):53-61.
14. Tanwar YS, Jamini M, Srivastava B. Formulation and in vitro evaluation of floating tablets of Losartan potassium. Mahidol University Journal of Pharmaceutical Sciences. 2013;40(2):17-24.
15. Padmavathy J, Saravanan D, Rajesh D. Formulation and evaluation of ofloxacin floating tablets using HPMC. International journal of pharmacy and pharmaceutical sciences. 2011;3(1):170-3.
16. Kumar R, Patil MB, Patil SR, Paschapur MS. Formulation and evaluation of effervescent floating tablet of famotidine. Int J Pharm Tech Res. 2009 Jul;1(3):754-63.
17. Aulton M. The Science of Dosage Form Design. 2nd Edition, Churchill Livingstone, Hungary, 2008: 111 & 310.
18. Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Pol Pharm. 2010 May 1;67(3):217-23.
19. Danki LS, Sayeed A, Kadam S, Salger S. Research Journal of Pharmaceutical, Biological And Chemical Scienes. vol. 2010 Sep;1:108-30.