Volume : 10, Issue : 05, May – 2023
Title:
55.EVALUATION OF ANTIANXIETY EFFECTS OF ALAFIA MULTIFLORA LEAVES EXTRACTS IN ANIMAL MODELS
Authors :
Md. Salma Sulthana, Gavini Saraswathi, Angidi Shireesha, Jallella Saikumar, Aminul Hoque, Abdus Samad
Abstract :
The presant study focuses on the investigation of anxiolytic effects of methanolic extracts prepared from the mixture of bark and fruits of alafia multiflora. The plant is collected and authenticated. The prepared extract is subjected to phytochemical screening and dose selection studies through acute toxicity studies. The classic anxiolytic benzodiazepine; diazepam has long been reported for its anxiolytic activity in rat with EPM. Alafia multiflora at doses of 100 mg/kg, and 200 mg/kg showed significant anxiolytic activity by increasing the number of entries in open arms along with time spent in open arms and significant reduction in time spent in closed arms. The effect of Alafia multiflora (100, 200 mg/kg) on number of entries in closed arms was insignificant. The anxiolytic activity shown at higher doses of Alafia multiflora (200 mg/kg) was comparable with Diazepam 2 mg/kg. p.o. Alafia multiflora at doses of 100 mg/kg & 200 mg/kg significantly increased the time spent and arm entries in open arms and decreased the time spent in closed arms compared to control. The time spent in neutral zone is also reduced by both the doses compared to control group. Decreased aversion to open arms compared to control group indicates the anxiolytic activity of stem bark of Alafia multiflora and the magnitude of anxiolytic effect of 200 mg/kg and 100 mg/kg extracts of Alafia multiflora were comparable to that of standard drug diazepam 2 mg/kg p.o.
Keywords: Alafia multiflora, diazepam, anxiety, herbal medicine etc.
Cite This Article:
Please cite this article in press Md. Salma Sulthana et al, Evaluation Of Antianxiety Effects Of Alafia Multiflora Leaves Extracts In Animal Models., Indo Am. J. P. Sci, 2023; 10 (05).
Number of Downloads : 10
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