Volume : 11, Issue : 12, December – 2024

Title:

FORMULATION AND EVALUATION OF CONTROL RELEASE TABLET OF REPAGLINIDE

Authors :

Vishal M. Kanoji*, Dr. Kamble H.V, Dr. Vivek M. Satpute, Mr. Sugriv R. Ghodake

Abstract :

This study focuses on the formulation and evaluation of sustained-release matrix tablets of Repaglinide, a drug widely used for the management of type 2 diabetes. Pre-formulation studies confirmed the physico-chemical properties of Repaglinide, including its melting point, solubility profile, and characteristic functional groups, ensuring the drug’s compatibility for sustained-release formulation. Calibration curves in ethanol, methanol, and phosphate buffer (pH 6.8) exhibited strong linearity, facilitating accurate drug quantification. Pre-compression parameters, including angle of repose, bulk density, tap density, Carr’s index, and Hausner ratio, demonstrated good flowability and compressibility. Post-compression evaluations indicated acceptable weight variation, friability, hardness, and uniform drug content across all formulations. In-vitro dissolution studies revealed that formulations F8 and F12 achieved prolonged drug release over 12 hours, with drug release rates of 84.91% and 99.92%, respectively. These results indicate that sustained-release matrix tablets of Repaglinide can be effectively formulated, offering a promising approach to enhance therapeutic efficacy and patient compliance in diabetes management.
Keywords: Repaglinide, sustained-release tablets, type 2 diabetes, pre-compression parameters, post-compression parameters, in-vitro dissolution, drug release, matrix formulation.

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Cite This Article:

Please cite this article in press Vishal M. Kanoji et al., Formulation And Evaluation Of Control Release Tablet Of Repaglinide..,Indo Am. J. P. Sci, 2024; 11 (12).

Number of Downloads : 10

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