Volume : 11, Issue : 12, December – 2024
Title:
REVIEW ON BUCCAL DRUG DELIVERY SYSTEM
Authors :
Appala Mavya Sri* and V.Saikishore
Abstract :
The buccal area of the oral mucosa delivers an elegant channel of systemic medication distribution within the mouth mucosa. Drugs are delivered via oral mucosal layer, that has a higher first-pass metabolism and degrades in gastrointestinal tract. The medication is immediately transmitted via the systemic circulation via the buccal drug delivery mechanism, which allows for painless administration, quick enzymatic action, high bioavailability, and reduced liver metabolism. The drug delivery system helps the drug to remain at the same place of application longer for once or twice daily dosing. For some drugs, the alternate way of administration results in novel methods of action as opposed to the above-said procedure. The characteristics of the oral mucosa as well as physicochemical properties of the drug pose as a hindrance to the oral mucosal administration of some drugs. Commercial availability of drug is restricted, although most of the drugs are qualitatively assessed for oral transmucosal delivery. This review paper provides a comprehensive overview of the oral mucosa, mucoadhesion, variables influencing the whole process, assessment methodologies, and how to eliminate obstacles when formulating buccal drug delivery formulations.
Keywords: Buccal mucosa, Bucoadhesion, Transmucosal route, Diffusion
Cite This Article:
Please cite this article in press Appala Mavya Sri et al., Review On Buccal Drug Delivery System..,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
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