Volume : 11, Issue : 12, December – 2024
Title:
ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF METFORMIN AND ERTUGLIFLOZIN IN PURE AND TABLET DOSAGE FORM BY RP-HPLC
Authors :
G Indira Priyadarshini*, K Sandhyarani, Nagaraju Pappula, V Mounika
Abstract :
A simple, accurate, precise HPLC method was developed for the simultaneous estimation of the Metformin and Ertugliflozin in Tablet dosage form. Retention time of Metformin and Ertugliflozin were found to be 2.336 min and 3.142 min. %RSD of the Metformin and Ertugliflozin were and found to be 0.3 and 0.3 respectively. %Recovery was obtained as 100.30% and 100.49% for Metformin and Ertugliflozin respectively. LOD, LOQ values obtained from regression equations of Metformin and Ertugliflozin were 0.72, 0.01 and 2.18, 0.04 respectively. Regression equation of Metformin is y = 5799x + 2367, and y = 44530x + 320.6 of Ertugliflozin. Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular quality control test in Industries.
Keywords: RP-HPLC, Method Development, Validation, Metformin and Ertugliflozin
Cite This Article:
Please cite this article in press G Indira Priyadarshini et al., Analytical Method Development And Validation For Simultaneous Estimation Of Metformin And Ertugliflozin In Pure And Tablet Dosage Form By RP-HPLC.,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
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