Volume : 11, Issue : 12, December – 2024
Title:
SELF-MICRO EMULSIFYING DRUG DELIVERY SYSTEMS FOR IMPROVED SOLUBILITY & BIOAVAILABILITY OF NEBIVOLOL
Authors :
K.Sandhya Rani, D.Raj Kumar
Abstract :
The application of solid self-micro emulsifying drug delivery systems (S-SMEDDS) is one potential formulation approach for Nevibolol. In this study, self-micro emulsifying (SME) combinations of oil, surfactant, and cosurfactant were developed and their emulsifying efficacy was evaluated. Formulation (F4) was shown to be the most effective based on the ternary phase diagram, droplet size, zeta potential, and in vitro drug release data. Self-emulsification in water was quick because of the improved formulation. These results suggest that SMEDDS can be utilized to improve the solubility and dissolution of previously poorly soluble chemicals, such as Nevibolol. In vitro drug release tests revealed that the F4 formulation exhibited a 78.86% and 99.05% drug release at 45 and 120 minutes, respectively.
Keywords: Nevibolol, Self-emulsification, S-SMEDDS, Oil, Surfactant and Co-surfactant.
Cite This Article:
Please cite this article in press Devara Raj kumar et al., Self-Micro Emulsifying Drug Delivery Systems For Improved Solubility & Bioavailability Of Nebivolol.,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
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