Volume : 11, Issue : 12, December – 2024
Title:
FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF ANTI-DIABETIC DRUG
Authors :
N.Manogna, D. Raj kumar
Abstract :
Abstract:
The objective is to develop and assess Repaglinide floating tablets. Based on FTIR tests, the medication is proven to be compatible with the excipients. The findings indicated that the drug release rates of the preparations were influenced by the drug-polymer ratio. The concentration of sodium bicarbonate has to be at least 10% to achieve buoyancy. The repaglinide formulations remained floating for more than 12 hours, whereas all of the other formulations (RP1–RP9) floated for more than 24 hours. The optimized formulation RP6 showed first-order release instead of zero-order release, indicating that the medication was released from RP1–RP9 by fickian diffusion.
Keywords: Repaglinide, floating tablets, drug-polymer, buoyancy, optimized formulation.
Cite This Article:
Please cite this article in press Devara Raj kumar et al., Formulation And Evaluation Of Gastroretentive Floating Tablets Of Anti-Diabetic Drug.,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
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