Volume : 11, Issue : 12, December – 2024
Title:
FORMULATION AND IN VITRO EVALUATION OF REPAGLINIDE-LOADED MICROSPHERES
Authors :
G.Laxmi Pavani, T.Ram Chander
Abstract :
The current study was conducted using floating repaglinide microspheres. The polymers HPMC 100 and ethyl cellulose were used. Micromeritic characteristics were tested on floating microspheres. A mean particle size of 381.55±2.54 to 493.24±2.43 micrometers was determined. For floating microsphere formulations F1 through F10, the yield ranged from 84.05±0.39 to 97.48±0.57. To increase the duration of a drug; stomach residence time, floating microspheres were prepared. In vitro, buoyancy ranged from 70.42±1.36 to 95.81±2.11 for formulations F1 through F10, respectively. The range of the entrapment efficiency for formulations F1 through F10 was 81.62±1.72 to 95.62±2.07. Formulations made using HPMC100 were shown to contain up to 90% of the medication, according to the dissolving data. For up to 12 hours, the F5 formulation delayed the maximal drug release.
Keywords: Repaglinide, Microspheres, Micromeritics, buoyancy, drug release.
Cite This Article:
Please cite this article in press Devara Raj kumar et al., Formulation & Evaluation Of Enteric-Coated Capsules For The Treatment Of Ulcerative Colitis.,Indo Am. J. P. Sci, 2024; 11 (12).
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