Volume : 11, Issue : 12, December – 2024
Title:
FORMULATION AND EVALUATION OF INVASOMAL GEL
Authors :
K.Nikhita, Zeenath Ruty
Abstract :
Invasomes laden with ketoconazole were made by a thin-film hydration technique. Drug-to-lipid ratios (IG1 to IG7) were varied to create seven formulations. The produced formulations were assessed for in vitro drug release studies, drug content, entrapment efficiency, zeta potential, and particle size. The viscosity values of the formulations with the highest amount of carbopol 934P (1.0 g) were 589 cp, while the formulations with the lowest amount (0.2 g) were 345 cp. The Spreadability analysis reveals a similar trend, with a less gelling agent and a higher Spreadability. 934P had the lowest value when there was a lot of carbopol present. In the “Homogeneity” investigation, every formulation showed that there was no aggregated mass or clog mass. The IG4 formulation of Invasomes was deemed the best of all the formulations. A prolonged drug release of 76.9% was seen at 14 hours with the “IG4” formulation. SEM analysis showed that the invasomes were distributed widely.
Keywords: Invasomes, thin-film hydration technique, gel, gelling agent, SEM analysis.
Cite This Article:
Please cite this article in press Zeenath Ruty et al Formulation And Evaluation Of Invasomal Gel .,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
References:
1. Dragicevic, N.; Verma, D.D.; Fahr, A. Invasomes: Vesicles for enhanced skin delivery of drugs. In Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement; Springer: Berlin, Germany, 2016; pp. 77–92.
2. P. K. Lakshmi, B. Kalpana, D. Prasanthi. Invasomes-novel Vesicular Carriers for Enhanced Skin Permeation. Systematic Reviews in Pharmacy, 2013, 4(1), 26-30.
3. Uzma Afreen, A. Krishna Shailaja. Overall Review on Invasomes. Research Journal of Nanoscience and Engineering, 3 (4), 2019, 5-9.
4. Kumar, L.; Verma, S.; Singh, K.; Prasad, D.; Jain, A. Ethanol Based Vesicular Carriers in Transdermal Drug Delivery: Nanoethosomes and Transethosomes in Focus. NanoWorld J. 2016, 2, 41–51.
5. Kamran, M.; Ahad, A.; Aqil, M.; Imam, S.S.; Sultana, Y.; Ali, A. Design, formulation and optimization of novel soft nano-carriers for transdermal olmesartan medoxomil delivery: In vitro characterization and in vivo pharmacokinetic assessment. Int. J. Pharm. 2016, 505, 147–158.
6. Zhou, W.; He, S.; Yang, Y.; Jian, D.; Chen, X.; Ding, J. Formulation, characterization and clinical evaluation of propranolol hydrochloride gel for transdermal treatment of superficial infantile hemangioma. Drug Dev. Ind. Pharm. 2015, 41, 1109–1119.
7. Ohradanova-Repic, A.; Nogueira, E.; Hartl, I.; Gomes, A.C.; Preto, A.; Steinhuber, E.; Mühlgrabner, V.; Repic, M.; Kuttke, M.; Zwirzitz, A. Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells. Nanomed. Nanotechnol. Biol. Med. 2018, 14, 123–130.
8. Karimi, N.; Ghanbarzadeh, B.; Hamishehkar, H.; Keivani, F.; Pezeshki, A.; Gholian, M.M. Phytosome and liposome: The beneficial encapsulation systems in drug delivery and food application. Appl. Food Biotechnol. 2015, 2, 17–27.
9. Gauhar R. Qadri, Abdul Ahad, Mohd. Aqil, Syed S. Imam & Asgar Ali. Invasomes of isradipine for enhanced transdermal delivery against hypertension: formulation, characterization, and in-vivo pharmacodynamic study, Artificial Cells, Nanomedicine, and Biotechnology, 2017. 45:1, 139-145,
10. Thanaporn Amnuaikit, Tunyaluk Limsuwana, Pasarat Khongkowb, Prapaporn Boonme. Vesicular carriers containing phenylethyl resorcinol for topical delivery system; liposomes, transfersomes and invasomes. Asian Journal of Pharmaceutical Sciences. 2018. 13,472–484.
11. Chaurasiya P., Ganju E., Upmanyu N., Ray S.K., Jain P. Transfersomes: A novel technique for transdermal drug delivery. J. Drug Deliv. Ther. 2019;9:279–285.
12. Bhasin B., Londhe V.Y. An overview of transfersomal drug delivery. Int. J. Pharm. Sci. Res. 2018;9:2175–2184. doi: 10.13040/IJPSR.0975-8232.9(6).2175-84.
13. Kim B., Cho H.-E., Moon S.H., Ahn H.-J., Bae S., Cho H.-D., An S. Transdermal delivery systems in cosmetics. Biomed. Dermatol. 2020;4:1–12. doi: 10.1186/s41702-019-0053-z
14. Jiang T., Wang T., Li T., Ma Y., Shen S., He B., Mo R. Enhanced transdermal drug delivery by transfersome-embedded oligopeptide hydrogel for topical chemotherapy of melanoma. ACS Nano. 2018;12:9693–9701.
15. Sivannarayana P., Rani A.P., Saikishore V., VenuBabu C., SriRekha V. Transfersomes: Ultra deformable vesicular carrier systems in transdermal drug delivery system. Res. J. Pharm. Dos. Forms Technol. 2012;4:243–255.