Volume : 11, Issue : 12, December – 2024
Title:
PREPARATION AND EVALUATION OF BUCCAL FILMS OF CARVEDILOL
Authors :
Khan Sanib Nazzer, Zeenath Ruhy
Abstract :
An impermeable backing layer was made of ethyl cellulose, and buccal films containing carvedilol were made using the polymers carbopol-P 934 (CP), sodium carboxymethyl cellulose (SCMC), hydroxypropyl methyl cellulose-100K cps (HPMC), and polyvinyl pyrrolidone K 30 (PVP). Through the use of Fourier transform infrared spectroscopy (FTIR), the compatibility of the medication and the polymer was examined. The generated carvedilol films were assessed for surface pH, swelling percentage, thickness, weight variation, hardness, friability, and active ingredient concentration.
Keywords: Carvedilol, Carbopol-P 934, buccal, films.
Cite This Article:
Please cite this article in press Zeenath Ruhy et al., Preparation And Evaluation Of Buccal Films Of Carvedilol .,Indo Am. J. P. Sci, 2024; 11 (12).
Number of Downloads : 10
References:
1. Biswajit B, Nabin K, Bhavesh B. Formulation and evaluation of repaglinide buccal tablet: ex vivo bioadhesion study and ex vivo permeability study. J Appl Pharm Sci 2014;4:96-103.
2. Kothiya OM, Patel BA, Patel KN, Patel MM. Formulation and characterization of sustained release matrix tablets of ivabradine using 32 full factorial design. Int J Appl Pharm 2018;10:59-66.
3. Balaji A, Radhika V, Goud V. Formulation and evaluation of mucoadhesive buccal tablets by using natural polymer. Int J Pharm Sci Res 2014;5:4699-708.
4. Barzegar JM, Ghanbarzadeh S, Adibkia K, Valizadeh H, Bibak S, Mohammadi G, et al. Development and characterization of solid dispersion of piroxicam for improvement of dissolution rate using hydrophilic carriers. Bioimpacts 2014;4:141-8
5. Deshkar S, Satpute A. Formulation and optimization of curcumin solid dispersion pellets for improved solubility. Int J Appl Pharm 2020;12:36-46.
6. Bhanja S, Ellaiah P, Mohanty C, Murthy KVR, Panigrahi B, Padhy S. Design and in vitro evaluation of mucoadhesive buccal tablets of perindopril prepared by sintering technique. Asian J Pharm Clin Res 2010;3:1-10
7. Oza N, Sahoo S, Sagar S. A 32 full factorial design for topical controlled release tazarotene microsponge using HPMC gel. Int J Appl Pharm 2019;11:12-8.
8. Ramana G, Apporva K, Naga Manasa G, Venkata Sai Sowjanya B, Sanjana J. Design and evaluation of sustained-release bilayer matrix tablets of propranolol hydrochloride. J Chem Pharm Sci 2019;12:58-64.
9. Paras M, Narendra C, Hardik P, Rajnikant S. Formulation and evaluation of buccal drug delivery system of ketorolac-tromethamine using mucoadhesive polymers. Int J Pharm Res 2017;9:42-9.
10. Arun JL, Rani S, Manoj Kumar P. Buccal drug delivery system: history and recent developments. Asian J Pharm Clin Res 2016;9:36-42.
11. Vajrala, L. L., Umashankar , M. S., & Alagusundaram , M. Formulation, Optimization and In-Vivo Pharmacokinetic Evaluation of Carvedilol Mucoadhesive Buccal Films by Using Natural Polymers: http://www.doi.org/10.26538/tjnpr/v7i10.32. Tropical Journal of Natural Product Research (TJNPR), 2023; 7(10), 4927–4936.
12. Prerana D. Navti, Rajashree S. Gude, Krupa G. Dharwadkar and Krati V. Naik. Formulation development and evaluation of chitosan based mucoadhesive bilayered buccal patches of carvedilol. IJPSR, 2020; Vol. 11(7): 3148-3159.
13. Adiba Mulla, Rasika Mulik. Formulation development of buccal film of carvedilol phosphate. EPRA International Journal of Research and Development (IJRD).2020;5(11):121-7.
14. Madhusudhan Reddy, K. Balaramanagakishore, P. Srinivasababu. Formulation and evaluation of Carvedilol buccal films. Indian Journal of Research in Pharmacy and Biotechnology, 2017;5(4), -. https://europub.co.uk/articles/-A-33464
15. Verma N, Chattopadhyay P. Effect of novel mucoadhesive buccal patches of carvedilol on isoprenaline-induced tachycardia. J Adv Pharm Technol Res. 2014 Apr;5(2):96-103. doi: 10.4103/2231-4040.133436.