Volume : 11, Issue : 12, December – 2024

Title:

FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF RISPERIDONE BY USING NATURAL POLYMERS

Authors :

C. Thanusha, J.Bharathi

Abstract :

The present work studied the natural polymer based once a day matrix tablet of Risperidone. From the wide range of hydrophilic polymers, k – carrageenan, λ – carrageenan and locust bean gum. Combinations of the two different gums k- carrageenan and locust bean gum and λ-carrageenan and locust bean gum were formulated in different ratios 20:80, 40:60, 50:50, 60:40 and 80:20 to exploit rheological synergism between two gums. Further the formulations were prepared dorm the formulation which exhibited maximum retardation such that each contains 10% less polymer concentration than the previous formulation in order to achieve the once-a-day matrix tablet of Risperidone containing least amount of polymer. The blends were prepared by non-aqueous wet granulation techniques with lactose as a diluent in formulations. The dried blends were compressed with other necessary excipients. The tablets were evaluated for hardness, thickness, drug content uniformity, in-vitro drug release studies for 24 hours (USP dissolution apparatus II, phosphate buffer-pH 6.8, 50 rpm, 37±0.5ºC), water uptake studies, swelling studies and in of the matrix tablet. The amount of Risperidone released from the tablet formulations was estimated at 210nm using a UV spectrophotometer. The kinetic analysis of selected formulations were performed and found to follow Korsmeyer-Peppas model through non-fickian transport mechanism. The following conclusions can be drawn from the above study. From the results obtained we can conclude that the polymers selected for the study, can be used individually for the sustained drug delivery of Risperidone locust bean gum was used in combination with k-carrageenan and λ-carrageenan in 60:40 and 20:80 ratios respectively with least in vitro drug release and can be used to reduce the concentration of polymer from the tablet.30% polymer reduction in case of k-carrageenan and locust bean gum and 20% with λ-carrageenan and locust bean gum combination was achieved.
Key words: Formulation Development, Invitro Evaluation, Sustained Release Matrix Tablets, Risperidone, Natural Polymers

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