Volume : 11, Issue : 07, July – 2024

Title:

A REVIEW ON MELT GRANULATION TECHNIQUES

Authors :

Anumula Chandra Kiran*, G Ramakrishna, M. V. Nagabhushanam,Malinedi Gowthami, Rompicharla Sushma, Tanniru Siva Pavani

Abstract :

In the process of creating pharmaceutical oral dosage forms, granulation is one of the most crucial unit processes. Granulation will enhance flow and compression properties, lessen segregation, increase content uniformity, and get rid of too many tiny particles. The outcomes will be better yields; fewer tablet faults, higher productivity, and less downtime. The collection of tiny particles into larger aggregates is referred to as an agglomeration or granulation. Agglomeration refers to the build up of small particles into larger aggregates with the help of a binding agent or mechanical force, such as water, starch paste, or roller compaction. Although both terms are similarly defined, inspection of the manufacturing process offers a simple method of differentiating the two aggregation phenomena. This analysis concentrates on the most recent developments.
Keywords: Granulation, Agglomeration, Segregation.

Cite This Article:

Please cite this article in press Anumula Chandra Kiran et al., A Review On Melt Granulation Techniques.,Indo Am. J. P. Sci, 2024; 11 (07).

Number of Downloads : 10

References:

1. A. Royce and J. Suryawanshi, 1992 AAPS Eastern Regional Meeting, Poster No. 48, Alternative granulation techniques: Wax granulation, 1992.
2. J. Suryawanshi, R. Sandry, A. Royce, and U. Shah, 1994 AAPS Eastern Regional Meeting, Poster No. 117, Process characterization of a wax granulation technique in a high shear mixer, 1994.
3. B. Lippold, in Oral Controlled Release Products, Therapeutic and Biopharmaceutic Assessment (U. GundertRerny and H. Moller, eds.), Wissenschaftliche Verlagsgesellschaft, Stuttgart, 1990, p. 39.
4. R. Gordon and D. Former, in Pharmaceutical Dosage Forms: Tablets, Vol. 2 (H. Lieberrnan, L. Lachman, and J. Schwartz, eds.), Marcel Dekker, New York, 1989, p. 245.
5. H. P. Bier, H. Leuenberger, and H. Sucker, Die Pharmazeutische Industrie, 41(4), 375-380 (1979).
6. T. Schaefer, P. Holm, and H. G. Kristensen, Drug Dev. Ind. Pharm., 16, 1249 (1990). H. Leuenberger and G. Imanidis, Pharrn. Tech., 10(3), 56 (1986).
7. T. Schaefer, P. Holm, and H. G. Kristensen, Acta Pharm. Nord., 4(4), 245 (1992).
8. P. Flanders, G. A. Dyer, and D. Jordan, Drug Dev. Ind. Pharm., 13(6), 1001 (1987).
9 .C. M. McTaggart, J. A. Ganley, A. Sickmueller, and S. E. Walker, Int. J. Pharm., 19, 139 (1984).
10. Brahmaiah Bonthagarala ,Varun Dasari,, Vijay Kotra, Suryakanta Swain, Sarwar Beg, Qualityby-Design based development and characterization of Pioglitazone loaded liquisolid compact tablets with improved biopharmaceutical attributes, Journal of Drug Delivery Science and Technology, 51 (2019), 345-355
11. Brahmaiah Bonthagarala, Varun Dasari, Vijay Kotra, Solubility enhancement effect at absorption site on bioavailability of Ritonavir using liquisolid technique, Therapeutic Delivery, 2019, Vol. 10, No. 05, 295-310.
12.Brahmaiah Bonthagarala , Prasanth Pasumarthi, Katta Vamshi Kiran, Sathram Nataraja, Sudarshan Donthiboina, Formulation and evaluation of orodispersable Atenolol Maleate Tablets: A comparative Study on Natural Super disintegrents and Synthetic Super disintegrents, International Journal of Research in Ayrveda and Pharmacy, ISSN(Online)-2299-3566, ISSN (Print)-2277-4343, 5(2), Mar-Apr 2014, 185-192.
13. Brahmaiah. B , Madhu Gudipati, GP Bhagath, Formulation and Evaluation of Gastro retentive Floating Drug Delivery System of Metoprolol Tartarate, International Journal of Life Sciences Biotechnology and Pharma Research, ISSN:2250-3137, Vol-2(1), 184-201, January 2013.
14. Brahmaiah Bonthagarala , Sreekanth Nama, Prasanna Kumar Desu, Formulation and Evaluation of Fast Dissolving Films of Sumatriptan, International Journal of Advanced Pharmaceutics, e-ISSN-2249-7706, Print-ISSN-2249-7714, Vol-3 (2), 2013, 102-109.
15. A thesis submitted in fulfillment of the requirement for the degree of Doctor of Philosophy by Melvin X. L. Tan. Bachelor of Engineering (Hons) Department of Chemical Engineering Monas University Clayton Victoria 3800 Australia, November, 2010, 1- 2621.
16. Anas Bhanassi, Dianazidon. Formulation and Evaluation of Aceclofenac fast Dissolving Tablet using Foam Granulation Technique. Indoglobal journal of Pharmaceutical sciences, 2(4), 2012, 342 – 347.
17. Himanshu. K. solanki, Tarashankar Basuri, Recent Advances In Granulation Technology. International Journal of Pharmaceutical Sciences Review and Research, 5(3), 2010, 48-54.
18. Lachman L, Lieberman H. A, Kanig JL, Third edition Granulation, The theory and practice of industrial pharmacy, Verghese Publishing House, Bombay, 1991, 58-59.
19. Mahammed Athar A. Saikh, A Technical Note on Granulation Technology: A Way to Optimize Granules. International Journal of Pharmaceutical Sciences and Research, 4 (1), 2012, 55 – 67. 20.Michael D. Tousey, The granulation process 101 Basic Technologies for Tablet Making Pharmaceutical Technology Tabletting and Granulation, 2002, 8-13.
21. Saikh Mahammed Athar Alli, Updated insight on Foamed Binder Granulation. International research journal of pharmacy, 4 (9), 2013, 35-40.
22. Shethvijay P. Ranpuravicky D. Steam Granulation: Novel Aspects In Granulation Techniques. International Journal of Pharmaceutical Sciences, 3(3), 2012, 2170 – 2184.
23. Yaswanth Allamneni, Navya Allamneni, Foam Granulation technology as a New Innovation in Granulation of Pharmaceutical drugs: An Over view. International journal of Pharmaceutical frontier research, 2 (2), 2012, 68-79