Volume : 11, Issue : 07, July – 2024
Title:
FORMULATION AND EVALUATION OF AQUASOMES FOR TRANSDERMAL DRUG DELIVERY OF AN ANTIBIOTIC DRUG
Authors :
Dr. Satkar Prasad, Sangeeta Dange
Abstract :
Transdermal drug delivery offers a promising approach to enhance the effectiveness and patient compliance of topical antibiotic therapies. This study focuses on formulating and evaluating Aquasomes as carriers for delivering Mupirocin, a potent antibiotic widely used in dermatology. Aquasomes are nano-sized vesicular structures known for their core-shell composition, designed to facilitate enhanced drug permeation through the skin. The formulation process involved encapsulating Mupirocin within Aquasomes, followed by a comprehensive evaluation of their physicochemical properties, in vitro drug release kinetics, skin permeation capabilities, and stability under varying storage conditions. Various analytical techniques were employed to assess the performance of Aquasomes as a drug delivery system. Results indicated successful formulation of Aquasomes with high entrapment efficiency, ensuring efficient encapsulation of Mupirocin. In vitro studies demonstrated controlled and sustained drug release from Aquasomes, suggesting their potential for prolonged therapeutic effects. Skin permeation studies revealed enhanced drug penetration, underscoring Aquasomes’ ability to improve transdermal drug delivery. Stability assessments confirmed that Aquasomes maintained their physical and chemical integrity across different storage conditions.This study provides valuable insights into the application of Aquasomes as carriers for Mupirocin in transdermal drug delivery, potentially enhancing its therapeutic efficacy in treating skin infections and offering a platform for developing user-friendly topical formulations. Further research, including preclinical and clinical trials, is essential to explore the clinical feasibility and safety of Aquasomes in practical dermatological applications. In conclusion, leveraging Aquasomes for transdermal drug delivery represents an innovative strategy to improve therapeutic outcomes and patient adherence in managing skin infections with Mupirocin.
Key words: Aquasomes, Mupirocin, Formulation, Evaluation
Cite This Article:
Please cite this article in press Sangeeta Dange et al., Formulation And Evaluation Of Aquasomes For Transdermal Drug Delivery Of An Antibiotic Drug.,Indo Am. J. P. Sci, 2024; 11 (07).
Number of Downloads : 10
References:
1. Cevc G, Schatzlein AG, Richardsen H, Vierl U. Overcoming semipermeable barriers such as the skin with ultradeformable mixed lipid vesicles transfersomes liposomes or mixed lipid micelles. Langmuir 2003;19:10753-63.
2. Chow GM, Gonzalves KE. Nanotechnology. Molecularly designed materials. J Am Chem Soc 1996;622:335-48.
3. Alleman E, Gurny R, Doelker E. Drug-loaded nanoparticles preparation method and drug targeting tissues. Eur J Pharm Biopharm 1993;39:173-91.
4. Picos DR, Carril MG, Fernandez-Mena D. Methods of obtaining biodegradable microspheres. Rev Cubana Farm 2001;35:126-35.
5. Kossovsky N, Gelman A, Rajguru S, Nguyen R, Sponler E, Hnatyszyn HJ, et al. Control of molecular polymorphism by a structured carbohydrate/ceramic delivery vehicle aquasomes. J Control Release 1996;39:383-8.
6. Cevc G, Blume G, Schatzlein A. Transdermal drug carriers: Basic properties, optimization and transfer efficiency in the case of epicutaneously applied peptides. J Controlled Release 1995;36:3-16.
7. Quintanar-Guerrero D, Ganem-Quintanar A, Allemann E, Fessi H, Doelker E. Influence of the stabilizer coating layer on the purification and freeze-drying of poly(D,L-lactic acid) nanoparticles prepared by an emulsion-diffusion technique. J Microencapsul 1998;15:107-19.
8. Kossovsky N, Gelman A, Hnatyszyn J, Sponsler E, Chow GM. Conformationally stabilizing self-assembling nanostructured delivery vehicle for biochemically reactive pairs. Nano Struct Mater 1995;5:233-47.
9. Banker GS, Rhodes CR. Modern Pharmaceutics. New York: Marcel Dekker Inc.; 1990;4:675-6.
10. Jain S, Mittal A, Jain AK. Enhanced topical delivery of cyclosporine-A using PLGA nanoparticle as carrier. Curr Nanosci 2011;7:524-30.
11. Oviedo R.I., Lopez S.A.D., Gasga R.J., Barreda C.T.Q. Elaboration and structural analysis of aquasomes loaded with indomethecin. Eur J Pharm Sci. 2007; 32:223-230.
12. Vyas S.P., Goyal A.K., Khatri K., Mishra N., Mehta A., Vaidya, B., et al. Aquasomes a nanoparticulate approach for the delivery of antigen. Drug Dev Ind Pharm. 2008; 34:1297-1305.
13. Khopade A.J., Khopade S., Jain N.K. Development of haemoglobin aquasomes from spherical hydroxyapatite cores precipitated in the presence of poly (amidoamine) dendrimer. Drug Dev Ind Pharm. 2002; 241:145-54.
14. Patel, S., et al., Aquasomes: a novel approach in drug carrier system. 2018. Banerjee S, Sen KK. Aquasomes: A novel nanoparticulate drug carrier. J Drug Deliv Sci Technol 2018; 43:446-452.
15. Jain SS, Jagtap PS, Dand NM, Jadhav KR, Kadam VJ. Aquasomes: a novel drug carrier. J Appl Pharm 2012;2(1):184-192.