Volume : 11, Issue : 07, July – 2024
Title:
FORMULATION AND IN VITRO EVALUATION OF APREMILAST SUSTAINED RELEASE MATRIX TABLETS
Authors :
K. Bala Bhavani Yogesh , R. Bhargavi Rani , B. Gayathri priya , Dr. N.B.V.Sivaram*
Abstract :
The purpose of the present study was to formulate and evaluate of sustained release tablets of Apremilast. Sustained release tablets of Apremilast were formulated with different concentrations of HPMC K 15,Sodium CMC and Guar Gum by using direct compression method and evaluated for the different evaluation parameters such as thickness, hardness, drug content uniformity, friability, in-vitro drug release studies and release kinetic studies were performed. All the evaluation parameters results were significant. In-vitro drug release studies were performed and drug release kinetics evaluated using the linear regression method was found to follow Zero order, First order, Matrix and Korsemeyer and Peppas’ equation. The prepared formulation shows better and significant results for all the evaluated parameters. The formulation A7 shows maximum percentage of drug release (99.45%) and prolonged release for time period of about 12h, there by improves the bioavailability and patient compliance.
Keywords: Apremilast, HPMC K 15,Sodium CMC and Guar Gum
Cite This Article:
Please cite this article in press N.B.V. Sivaram et al Formulation And In Vitro Evaluation Of Apremilast Sustained Release Matrix Tablets.,Indo Am. J. P. Sci, 2024; 11 (07).
Number of Downloads : 10
References:
1. Singh Surya Pratap, Soni Shankar Lal, Khinchi Mahaveer Prasad, Gulia Ritu, Namdev Abhisek. A Brief Review On Sustained Release Matrix Tablets Of Baclofen. 01/12/2014.
2. Chien Y. W., “Novel Drug Delivery System” (IInd Edn), Revised and expanded, 1992,p.no.139-140.
3. Remington, “The Science and Practice of pharmacy”, 20th Edn, vol.I, p.no.903-913
4. Brahmankar D. M. and Jaiswal S .B. in “Biopharmaceutics and Pharmacokinetics”, “A Treatise,” Vallabh Prakashan, 1st edn, 1995,p.no.347- 352.
5. Lee V. H., Robinson J. R. in ,“Sustained and Controlled Release Drug Delivery System ” Marcel Dekker, New York, p.no. 71-121.,138-171.
6. Lachman Leon, Liberman H.A.and Kanig J.L., “The Theory and Practice of industrial pharmacy” (3rd Edn), Varghese publishing House Bombay, p.no.430.
7. Shargel, L and Yu, ABC (1999), “Modified release drug products”, Applied Biopharmaceutics and Pharmacokinetics, 4th Ed., McGraw Hill, 169-171.
8. Schall, R and Luus, HG (1997), “Bioequivalence of controlled-release calcium antagonists”, Clinical Pharmacokinetics, 32, 75-89.
9. Jantzen, GM and Robinson, JR (1995), “Sustained and controlled-release drug delivery systems”, Modern Pharmaceutics, 3rd Ed., Marcell Dekker, Inc. New York, 72, 575-609.
10. H.D.Zalte , R.B.Saudagar. Review On Sustained Release Matrix Tablet. IJPBS |Volume 3| Issue 4 -OCT-DEC-2013,17-29.
11. Ratnaparkhi M.P., Gupta J.P., Sustained Release Oral Drug Delivery System – An Overview International Journal of Pharma Research & Review. 2(3):11-21, 2013
12. Vyas S.P, Khar R.K.,Controlled drug delivery concept and advances, 2nd Edn Delhi:1-53,(2012)
13. Robinson J.R, Lee V. L, Controlled Drug Delivery:Fundamentals and Applications, 2nd Edn Published by Informa healthcare USA:373-421(2009)
14. Aulton M.E.,Aulton pharmaceutics the design and manufacture of medicins.3rd Edn published by Churchill Livingstone, Elsevier:441-482(2007).
15. Pundir S., Badola A.,Sharma D.,Sustained release matrix technology and recent advance in matrix drug delivery system : a review. International Journal of Drug Research andTechnology,3(1):12-20, (2013).