Volume : 11, Issue : 07, July – 2024
Title:
A REVIEW ON SPECTROSCOPIC ANALYSIS OF AMLODIPINE
Authors :
Amritha. A*, Dileep. C. Babu*, Varsha Suresh*, Mrs. Dhanya. S, Mr. Nishad V.M, Dr. R. Xavier Arulappa, Dr. Prasobh G.R
Abstract :
Hypertension is one of the most common communicable diseases nowadays and is the leading cause of death worldwide, affecting 1.4 billion people. Treatment options include the widely used calcium channel blockers, among which amlodipine, a dihydropyridine, has low renal clearance and long half-life and duration of action, which allows it to sustain its anti-hypertensive effect for more than 24 h following a single dose. It has proven to reduce BP variability and successfully lower BP. A simple, sensitive, specific, and validated UV method has been developed for the quantitative determination of Amlodipine besylate in pure and tablet dosage form. UV methods are simple, rapid, and cost-effective. They are suitable for routine quality control analysis in pharmaceutical formulations. UV spectroscopy avoids the need for complex separation techniques.
Key Words: Amlodipine, UV Spectroscopy, L type calcium channel blockers.
Cite This Article:
Please cite this article in press Amritha.A et al Formulation And Evaluation Of Aloin Loaded Microspheres To Treat Diabetes.,Indo Am. J. P. Sci, 2024; 11 (07).
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References:
1. Reynolds EF, editor. The Extra Pharmacopoeia. 31st ed. London: The Royal Pharmaceutical Society; 1996. p. 819-20.
2. Pahor M, Psaty BM, Alderman MH, et al. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Lancet. 2000; 356:1949-54.
3. Saravu K, Balasubramanian R. Near-fatal amlodipine poisoning. J Assoc Physicians India. 2004; 52:156-7.
4. Russel RP. Side effects of calcium channel blockers. Hypertension. 1988; 13.
5. Pahor M, Psaty BM, Alderman MH, et al. Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Lancet. 2000; 356:1949-54.
6. Lai YM, Fukuda N, Su JZ, et al. Novel mechanisms of the ant proliferative effects of amlodipine in vascular smooth muscle cells from spontaneously hypertensive rats. Hypertens Res. 2002; 25:109-15.
7. Yeung PK, Mosher SJ, Pollak PT. Liquid chromatography assay for amlodipine: chemical stability and pharmacokinetics in rabbits. J Pharm Biomed Anal. 1991; 9(7):565-71.
8. Beresford AP, Macrae PV, Stopher DA, Wood BA. Analysis of amlodipine in human plasma by gas chromatography. J Chromatogr B Biomed Sci Appl. 1987; 420:178-83.
9. Mohammadi A, Rezanour N, Ansari Dogaheh M, Ghorbani Bidkorbeh F, Hashem M, Walker RB. A stability- indicating high-performance liquid chromatographic (HPLC) assay for the simultaneous determination of atorvastatin and amlodipine in commercial tablets. J Chromatogr B. 2007;846(1):215-21.
10. Mhaske RA, Garole DJ, Mhaske AA, Sahasrabudhe S. RP-HPLC method for simultaneous determination of amlodipine besylate, valsartan, telmisartan, hydrochlorothiazide and chlorthalidone: application to commercially available drug products. Int J Pharm Sci Res. 2012; 3:141-9.




