Volume : 11, Issue : 07, July – 2024
Title:
PREPARATION AND CHARACTERIZATION OF NICARIDIPINE BUCCAL MUCOADHESIVE TABLETS
Authors :
Sandeep Panwar*, Dharmendra Singh Rajput, Naveen Gupta
Abstract :
Hypertension is a medical condition where the blood pressure is chronically elevated is one of the commonly found diseases throughout the world. Buccal route of drug delivery have significant attention to the systemic circulation through the jugular vein bypassing the first pass hepatic metabolism leading to high bioavailability. Such routes haveexpanded important notice due to their presystemic metabolism or instability in the acidic environment associated with the oral administration. Along with the variety of buccal layer mucosae of the oral cavity has convenient and easily effective site for the delivery of therapeutic agents. Nicardipine belongs to the drug class known as calcium channel blockers. It relaxes and dilates the blood vessels thereby allowing blood to flow more freely throughout the body. The buccal route has long been advocated as possible route of delivery of drugs having poor oral bioavailability because of high first pass metabolism or degradation in the gastrointestinal tract. The buccal mucosa reaching the heart directly via the internal jugular vein as this route is well vascularised with venous blood draining. Although, the drug fluxes via this route are less than that obtained with sublingual mucosa due to permeability barrier, the relative immobility of buccal musculature, as compared to that of sublingual route, makes this site ideally suited for delivery of drugs. The aim of the present research work is to develop buccal tablets of Nicardipine hydrochloride to reduce dosage frequency; obtain optimized and controlled therapy, better patient compliance.
Keywords: Nicardipine; Buccal tablet; Mucoadhesive; Drug Release; HPMC; Carbopol 934, SCMC
Cite This Article:
Please cite this article in press Sandeep Panwar et al., Preparation And Characterization Of Nicaridipine Buccal Mucoadhesive Tablets, Indo Am. J. P. Sci, 2024; 11 (07).
Number of Downloads : 10
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