Volume : 11, Issue : 03, March – 2024

Title:

ROLE OF VITAMIN C AND E AGAINST CADMIUM TOXICITY IN FEMALE WISTAR ALBINO RATS OVARIES, LIVER AND KIDNEY

Authors :

Sudarshana ⃰, Dr. Pawan Kumar , Dr. K.K. Yadav

Abstract :

Cadmium is a heavy metal present almost everywhere in the environment and it causes toxicity to different organs of body in female wistar albino rats. Cadmium exposure causes adverse effect to different target organs like kidney, liver and ovaries. The purpose of present study is to evaluate effect of vitamin C and E against cadmium toxicity in female wistar rats. Rats are divided in four groups and we provide different does of cadmium (3/5/7mg/lit) with vitamin C and vitamin E (100mg/kg b.w.). Vitamin C and E shows recovery effect against cadmium toxicity in different organs. The tissue and blood sample were taken from rats for histological analysis after 14 days. Hematological analysis, serum biochemical analysis histopathology of kidney, liver and ovarian tissue of different group of female treated with 3/5/7 mg/lit and (100 mg/kg) show recovery effect of ovary, liver and kidney. The result obtained from present study show protective effect against cadmium toxicity. Vitamin C and E has beneficial effect in the amelioration of cadmium toxicity in female wistar rats.
Keywords: Cadmium, vitamin C, Vitamin E, protective effect, wistar rats, ovary, liver, kidney, heavy metal.

Cite This Article:

Please cite this article in press Sudarshana et al., Role Of Vitamin C And E Against Cadmium Toxicity In Female Wistar Albino Rats Ovaries, Liver And Kidney., Indo Am. J. P. Sci, 2024; 11 (03).

Number of Downloads : 10

References:

1. Andjelkovic M., Djordjevic A.B., Antonijevic E., Anttonijevic B., Stanic M., Stevulijevic J.K., Kalimanovska V., Jovanovic M., Boricic N., Wallace D., Bulat Z., 2019. Toxic effect of acute cadmium and lead exposed in rat blood, liver and kidney. Review, International Journal of environmental and public health, 16(2), 1-21.
2. Bernard A., Lauwerys R., & Gengoux P.,1981. Characterization of the proteinuria induced by prolonged oral administration of cadmium in female rats. Toxicology, 20 (4), 345-57.
3. Filipic M., 2012. Mechanisms of cadmium induced genomic instability. Mutation research / Fundamental and molecular mechanism of mutagenesis, 733(1-2), 69–77.
4. Han Y.L., Sheng Z., Liu G.D., Long L.L., Wang Y.F., Yang W.X, Zhu J.Q., 2015 Cloning, characterization and cadmium inducibility of metallothionein in the testes of the mudskipper Boleophthalmus pectinirostris. Ecotoxicol Environmental Safety, 119, 1–8.
5. Joseph P., 2009. Mechanisms of cadmium carcinogenesis. Toxicology and Applied Pharmacology, 238 (3), 272–279.
6. Layachi N., and Kechrid Z., 2012. Combined protective effect of vitamins C and E on cadmium-induced toxicity liver injury in the rat. African Journal of Biotechnology, 11(93), 16013-16020.
7. Mattie M.D., Freedman J.H., 2001. Protective effects of aspirin and vitamin E (α-tocopherol) against copper-and cadmium-induced toxicity. Biochemical and Biophysical Research Communications 285(4), 921–925.
8. Nakano M, Onodera A, Saito E, Tanabe M, Yajima K, Takahashi J., Chuyen N.V.,2008. Effect of astaxanthin in combination with alpha-tocopherol or ascorbic acid againt oxidative damage in diabetic ODS rats. J Nutr Sci Vitaminol (Tokyo), 54(4), 329–334.
9. Omonkhua, A.A., Obi F.O., 2012. Effects of Vitamin C on Kidney and Bone of Rats Exposed to Low Doses of Cadmium. Nigerian Journal of Basic and Applied Sciences. 20 (4), 297-304.
10. Patrick L., 2003. Toxic metals and antioxidants: Part II The role of antioxidants in arsenic and cadmium toxicity. Alternative Medicine Review, 8(2), 106–28.
11. Peter M., Róbert T., Ferdinand N., 1995. Concentrations of cadmium in ovary, oviductus, uterus, testis and tunica albuginea of testis in cattle. Journal of Environmental Science Health. Part A: Environmental Science and Engineering and Toxicology, 30(8), 1685–1692.
12. Pollack A.Z., Ranasinghe S., Sjaarda L.A., Mumford S.L., 2014. Cadmium and reproductive health in women: a systematic review of the epidemiologic evidence. Current Environmental Health Reports 1(2), 172–184.
13. Poli, V., Aparna, Y., Madduru R., Motireddy S.R., 2022. Protective effect of Vitamin C and E on enzymatic and antioxidant system in liver and kidney toxicity of Cadmium in rats. Applied Food Research, 2 (1), 100098.
14. Rahimzadeh M. R., Rahimzadeh M. R., Kazemi S, Moghadamnia A., 2017 Cadmium toxicity and treatment: An update. Caspian Journal of Internal Medicine, 8(3), 135–45.
15. Gupta R. S., Kim J., Gomes C., Oh S., Park J., Im W.B., Seong J.Y., Ahn R.S., Kwon H.B., Soh J., 2004. Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Molecular and Cellular Endocrinology 221(1-2), 57–66.
16. Sudarshana, Kumar P., Yadav K.K., 2023. Role of cadmium in inhibiting female fertility in wistar rats. International journal of food and nutritional sciences, 2(1), 1175-1185.