Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION AND IN-VITRO EVALUATION OF IMMEDIATE RELEASE TABLETS CONTAINING FEBUXOSTAT
Authors :
Narottam Pal*, A.Srinivasa Rao, Farah Naheen Sultana, Devakoti Nikitha
Abstract :
The aim of the present study is to develop and evaluate the immediate release tablet of Febuxostat by direct compression method. The Superdisintegrant Primojel, Ac-Di-Sol and PolyplasdoneXL10 were used for immediate release of drug from tablet. The prepared tablets were evaluated for all pre-compression parameters and post-compression parameters. The drugexcipients interaction was investigated by FTIR. All formulation showed compliances with Pharmacopoeial standards. The study reveals that formulations prepared by direct compression F3 exhibit highest dissolution using Crospovidone showed faster drug release 98.01% over the period of 45min while disintegration time of the tablet was showed 25sec comparison to other formulations of Febuxostat.
Keywords: Febuxostat, superdisintegrant and Immediate release tablet.
Cite This Article:
Please cite this article in press Narottam Pal et al., Formulation And In-Vitro Evaluation Of Immediate Release Tablets Containing Febuxostat..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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