Volume : 11, Issue : 11, November – 2024
Title:
DEVELOPMENT AND OPTIMIZATION OF SOLID LIPID NANOPARTICLES OF ESCITALOPRAM
Authors :
G Pravallika, P Sobitha Rani*, A Srinivasa Rao, A Kishore Babu, P Udaya Chandrika
Abstract :
Objective: The study aimed to develop and optimize solid lipid nanoparticles (SLNs) for the delivery of Escitalopram, an antidepressant medication, to enhance its bioavailability, stability, and therapeutic efficacy.
Methods: SLNs encapsulating Escitalopram were formulated using various lipid matrices and surfactants via high-shear homogenization and solvent evaporation techniques. Key formulation parameters such as lipid-to-drug ratio, surfactant concentration, and preparation methods were systematically optimized to achieve the desired particle size, encapsulation efficiency, and stability. The developed SLNs were characterized for particle size, size distribution, zeta potential, morphology, and drug loading. In vitro drug release studies were conducted to evaluate the release profile, and preliminary safety assessments were performed.
Results: The optimized SLNs exhibited a controlled particle size with a narrow size distribution, high drug encapsulation efficiency, and favorable zeta potential, indicating good stability. The release profile demonstrated a sustained release of escitalopram, suggesting an improved control over drug delivery compared to conventional formulations. Preliminary safety evaluations confirmed the biocompatibility of the SLNs, supporting their potential for safe therapeutic use.
Conclusion: The successful development and optimization of escitalopram-loaded SLNs offer a promising alternative to traditional drug delivery systems, with enhanced stability and controlled release properties. These findings suggest potential improvements in patient compliance and therapeutic efficacy. Future studies should focus on in vivo evaluations and clinical trials to further validate the benefits of the SLNs in therapeutic.
Keywords: Escitalopram solid lipid Nanoparticles
Cite This Article:
Please cite this article in press P Sobitha Rani et al., Development And Optimization Of Solid Lipid Nanoparticles Of Escitalopram..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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