Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION DEVELOPMENT AND IN-VITRO EVALUATION OF EXTENDED-RELEASE TABLETS CONTAINING AZILSARTAN
Authors :
Satyabrata Jena*, Mohammad Sadik Khanushiya, Lalith Sagar Reddy Gade,Sabita Sahoo, A V Kishore Babu, A Srinivasa Rao
Abstract :
The current work was focused to formulate and evaluate extended release tablets of Azilsartan. Eudragit RL, Ethyl Cellulose and Carbopol p934 are matrix polymer can be used in formulation of extended release dosage form. Azilsartan was considered as ideal drug for extended release formulation. The extended release matrix of Azilsartan were prepared by direct compression method in differ matrix polymers ratio. Pre formulation studies have been performed for the Active Pharmaceutical Ingredient. Drug Excipient compatibility studies have been performed and the tablets have been prepared in eight different formulations with the change in the ratios of polymers. These tablets are evaluated for various parameters including the release of drug by using dissolution studies. Hence the study resulted in the development of Azilsartan extended release tablets F4 formulation was considered as optimized formulation. The Kinetic treatment of selected formulation F4 showed that the release of drug follows Zero order models.
Keywords: Azilsartan, Eudragit RL, Ethyl Cellulose, Carbopol p934 and extended release tablets.
Cite This Article:
Please cite this article in press Satyabrata Jena et al., Formulation And In-Vitro Evaluation Of Immediate Release Tablets Containing Febuxostat..,Indo Am. J. P. Sci, 2024; 11 (11).
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