Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION, EVALUATION AND OPTIMIZATION OF NITROFURANTOIN DELAYED RELEASE MATRIX TABLETS
Authors :
Narottam Pal*, A.Srinivasa Rao, Devakoti Nikitha, Farah Naheen Sultana
Abstract :
The aim of the present work was to develop an extended-release dosage form of Nitrofurantoin. Tablets of the above said drug were prepared using hydrophobic and hydrophilic polymers like Badham Gum, Cashew nut tree gum and synthetic polymers Eudragit L- 100 and HPMC K4M, prepared by direct compression method and evaluated for various pre and post compression parameters. Hydrophobic matrix tablets failed to prolong the drug release, whereas Hydrophilic based matrix tablets showed good drug release. Whereas from the dissolution studies it was evident that the formulation (F7) showed better and desired drug release pattern i.e., 99.10 % in 12 hours. It contains the Eudragit L- 100 as extended release material. It followed peppas release kinetics mechanism.
Keywords: Nitrofurantoin, Badham Gum, Cashew nut tree gum, Eudragit L- 100, HPMC K4M, direct compression and extended release system.
Cite This Article:
Please cite this article in press Narottam Pal et al., Formulation, Evaluation And Optimization Of Nitrofurantoin Delayed Release Matrix Tablets..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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