Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION DEVELOPMENT AND INVITRO EVALUATION OF TIZANIDINE ORAL DISINTEGRATING TABLETS
Authors :
Syed Areefulla Hussainy*, Lubna Zeenath, Abdul Sayeed and Faizan Sayeed
Abstract :
In the present work, chewable release tablets of Tizanidine were prepared by wet granulation method. All the tablets were subjected to weight variation, drug content uniformity, and hardness, and friability, water absorption ratio, wetting time, dissolution, drug excipients interaction and short-term stability FT-IR spectra of the physical mixture revealed that the drug is compatible with the polymers used. The invitro drug release decreased with optimum amount of super disintegrent in the concentration.The formulation TF6 with SSG showed a maximum release of 99.45 % at 18 min. Analysis of drug release mechanism showed that the drug release from the formulations followed the best fit higuchi’s model of drug release diffusion mechanism and follows First order kinetics. Based on the results of evaluation tests formulation coded TF6 was concluded as best formulation.
Keywords: Oro-disintegrating Tablets, Tizanidine, Sublimation Techniques, Direct Compression Techniques.
Cite This Article:
Please cite this article in press Syed Areefulla Hussainy et al., Formulation Development And Invitro Evaluation Of Tizanidine Oral Disintegrating Tablets..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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