Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION AND IN-VITRO EVALUATION OF MICONAZOLE BUCCAL PATCHES
Authors :
Faizan Sayeed*, Rubeena Sultana, Syed Areefulla Hussainy, and Abdul Sayeed
Abstract :
The novel trans-buccoadhesive patches of Miconazole were prepared by solvent casting technique by employing the polymers of HPMC, Guar gum and Carbopol to obtain Miconazole buccal patches. The Miconazole buccal mucoadhesive patches were prepared by the method of solvent casting technique employing ‘O’ shape ring placed on a glass surface as substrate by using different polymers such as Hydroxy Propyl Methyl Cellulose – 15 cps (HPMC), Guar gum and Carbopol. Propylene glycol serves as the plasticizer as well as penetration enhancer.The prepared Miconazole mucoadhesive buccal patches were characterized based upon their physico-chemical characteristics like surface pH, swelling percentage, thickness, weight variation, hardness, Percentage Moisture Absorption and Percentage Moisture Loss, drug content andIn-vitro drug release study was performed by usingModified Franz diffusion cell release studies. Based on the results of evaluation tests formulation coded Mf7 was concluded as best formulation. And the optimized formulation folloes First order Higuchi’s drug release mechanism.
Keywords: Miconazole, Buccal Patches, Solvent Casting Techniques
Cite This Article:
Please cite this article in press Faizan Sayeed et al., Formulation And Invitro Evaluation Of Miconazole Buccal Patches..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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