Volume : 11, Issue : 11, November – 2024
Title:
ANTI-INFLAMMATORY ACTIVITY OF COMBINATIONAL EXTRACT OF CALOTROPIS GIGANTEA AND CALOTROPIS PROCERA LEAVES
Authors :
Satyanshai Sharan*, Dr. B.K. Dubey, Dr. Deepak Kumar Basedia, Dr. Sunil Saha, Mr. Bhusan Korde
Abstract :
This study investigates the anti-inflammatory activity of the ethanolic extracts of Calotropis gigantea and Calotropis procera leaves, both individually and in combination, using the formalin-induced paw edema model in rats. The percentage yield of the ethanolic extracts was 7.21% for C. gigantea and 8.74% for C. procera. Phytochemical screening revealed the presence of flavonoids, phenols, and saponins in C. gigantea, and additional glycosides and carbohydrates in C. procera. Quantitative estimation showed higher levels of flavonoids and phenols in C. procera, which may contribute to its enhanced anti-inflammatory effects. The anti-inflammatory activity of the extracts was evaluated by measuring paw edema after formalin injection, with both extracts showing significant reductions in paw volume. The ethanolic extract of C. gigantea reduced paw edema by 43.15% and 51.15% at doses of 100 mg/kg and 200 mg/kg, respectively. The extract of C. procera showed a stronger effect, with a reduction of 48.42% at 100 mg/kg and 55.57% at 200 mg/kg. The combination of both extracts at 100 mg/kg led to a 57.68% reduction in paw edema, suggesting a synergistic anti-inflammatory effect. These results indicate that both plants, individually and in combination, possess significant anti-inflammatory potential, supporting their use as natural remedies for inflammatory conditions.
Keywords: Calotropis gigantea, Calotropis procera, anti-inflammatory activity, ethanolic extract, formalin-induced paw edema, flavonoids, phenols, saponins, synergistic effect, natural remedies.
Cite This Article:
Please cite this article in press Satyanshai Sharan et al., Anti Inflammatory Activity Of Combinational Extract Of Calotropis Gigantea And Calotropis Procera Leaves..,Indo Am. J. P. Sci, 2024; 11 (11).
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