Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION AND IN-VITRO EVALUATION OF BUCCAL TABLETS OF ATENOLOL
Authors :
Abdul Sayeed*, Ishrath Fatima, Syed Areefulla Hussainy and Faizan Sayeed
Abstract :
The aim of the study was to explore the drug delivery system of Atenolol for treatment of antihypertensive. A satisfactory attempt was made to develop buccal drug delivery system of Atenolol and evaluate it. Influence of the formulation variables on hardness, drug uniformity, mucoadhesive strength, drug release is evident. Formulation Af5 has successfully sustained the release of Atenolol in buccal cavity, with great mucoadhesive strength. The formulation Af5 showed good pre compression and post compression parameters and followes Zero order and higuchi kinetics. After the Stability studies the optimized formulation doesn’t show any remarkable change in drug release. Based on the all experiment results it can be concluded that Guar gum and sodium alginate containing buccal formulation would be the suitable candidate for mucoadhesive drug delivery of Atenolol with sustainedrelease properties for the treatment of Antihypertensive.
Cite This Article:
Please cite this article in press Abdul Sayeed et al., Formulation and in-vitro evaluation of buccal Tablets of atenolol..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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