Volume : 11, Issue : 11, November – 2024
Title:
FORMULATION AND EVALUATION OF FLOATING EFFERVESCENT TABLETS OF CIMETIDINE
Authors :
Shaista Fatima, Fouzia Khanam, Ruhi anjum * , Faizan sayeed
Abstract :
The Floating Sustained released tablets using effervescent agent containing Cimetidine SR tablets were successfully prepared by wet granulation method. The physiochemical evaluation results for the granules of all trials pass the official limits in angle of repose, compressibility index. The prepared granules were also maintained the physiochemical properties of tablets such as thickness, hardness, weight variation, friability. The optimized formulation contains the average thickness of 3.11±0.02, average hardness of 4.94±0.05, average weight of 300±0.05, friability of 0.45. The optimized formulation F7 which releases the Cimetidine in sustained manner in 1st hour it releases 11.3% but the remaining drug release was sustained up to 8 hours. From the kinetics drug releases the optimized formulation, F7 have displayed zero order release. Hence it may be summarized that the F7 tablets prepared by wet granulation method for sustained release tablets might be a perfect and effective formulation to treat the Peptic ulcer.
Keywords: SR tablets, effervescent, wet granulation, compressibility.
Cite This Article:
Please cite this article in press Shaista Fatima et al ., Formulation And Evaluation Of Floating Effervescent Tablets Of Cimetidine..,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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