Volume : 11, Issue : 11, November – 2024
Title:
DESIGN, FORMULATION AND CHARACTERIZATION OF ISAVUCONAZOLE BUCCAL TABLETS
Authors :
Yerrolu Swetha*, L. Satyanarayana
Abstract :
Objective: Isouvconazole is an Antifungal drug used to treat invasive fungal infections. it has oral bioavailability (98%) and half-life 130 hr. It is administered through the buccal mucosa enters directly in the systemic circulation, thereby minimizing the first pass hepatic metabolism and adverse gastro-intestinal effects. Therefore, the present investigation is concerned with the development of the buccal tablets.
Methods: The present work was performed to develop and evaluate buccal tablet containing anti-fungal drug (Isovuconazole). Guargum was used as bucco adhesive polymer. Thickness, hardness, weight variation and drug uniformity were investigated.
Results: The tablet formulations were also subjected to drug release in 900 ml 6.8 phosphate buffer. Ex vivo bioadhesion, was determined. F6 formulations showed maximum amounts of drugs release (99.12%) at the end of 10 hrs dissolution study. F6 also showed maximum bioadhesion (0.276 N).
Conclusion: The results of the study suggested that new buccal tablet formulations of guar gum bucco adhesive polymer can be suitably developed as an alternate to conventional dosage forms.
Keywords: Isovuconazole, Buccal tablet, Ex vivo bioadhesion, Guargum.
Cite This Article:
Please cite this article in press Yerrolu Swetha et al., Design, Formulation And Characterization Of Isavuconazole Buccal Tablets.,Indo Am. J. P. Sci, 2024; 11 (11).
Number of Downloads : 10
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