Please cite this article in press Sandhya Karumanchi et al., A Review Article On Licorice (Glycyrrhiza Glabra Linn)., Indo Am. J. P. Sci, 2024; 11 (11).

1. Grace MS, Dubuis E, Birrell MA, Belvisi MG (2013) Pre-clinical studies in cough research: Role of Transient Receptor Potential (TRP) channels. Pulm Pharmacol Ther 26: 498-507.
2. Badkhane Y, Yadav AS, Bajaj A, Sharma AK, Raghuwanshi DK (2014) Glycyrrhiza glabra L. A Miracle Medicinal Herb. Indo American J Pharm Res 4: 5808-5813.
3. Azwanida NN (2015) A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation. Med Aromat Plants 4: 196.
4. Yi W, Wetzstein HY (2011) Effects of drying and extraction conditions on the biochemical activity of selected herbs. Hort Sci 46: 70-73.
5. San AMM, Thongpraditchote S, Sithisarn P, Gritsanapan W (2013) Total Phenolics and Total Flavonoids Contents and Hypnotic Effect in Mice of Ziziphus mauritiana Lam. Seed Extract. Evidence-Based Complement Alternat Med 2013: 1-4.
6. T hermo Scientific (2013) Methods Optimization in Accelerated Solvent Extraction. Tech Note 208: 1–4
7. Mukhopadhyay M, Panja P (2008) A novel process for extraction of natural sweetener from licorice (Glycyrrhiza glabra) roots. Sep Purif Technol 63: 539-545.
8. Kaufmann B, Christen P (2002) Recent extraction techniques for natural products: microwave-assisted extraction and pressurised solvent extraction. Phytochem Anal 13: 105-113.
9. Trusheva B, Trunkova D, Bankova V (2007) Different extraction methods of biologically active components from propolis: a preliminary study. Chem Cent J 1: 13
10. Dalgleish T, Williams JMG, Golden AMJ, Perkins N, Barrett LF, et al. (2007) Reduced specificity of autobiographical memory and depression. J Exp Psychol Gen 136: 23-42.
11. Dhanani T, Shah S, Gajbhiye NA, Kumar S (2017) Effect of extraction methods on yield, phytochemical constituents and antioxidant activity of Withania somnifera. Arab J Chem 10: 1193-1199
12. Mukherjee P K, Wahile A, Integrated approaches towards drug development from Ayurveda and other Indian system of medicines, J Ethnopharm 2006; 103, 25-35. https://doi.org/10.1016/j.jep.2005.09.024
13. Karahana F, Avsarb C, Ilker I O, Berber I, Antimicrobial and antioxidant activities of medicinal plant Glycyrrhiza glabra var. glandulifera from different habitats, Biotech Biotechnological Equip 2016 ; 1-8
https://doi.org/10.1080/13102818.2016.1179590
14. Tene V, Malago O, Finzi P V, Vidari G, An ethnobotanical survey of medicinal plants used in Loja and Zamora chinchipi. Equador, J Ethnopharm 2007; 111: 63-81.
https://doi.org/10.1016/j.jep.2006.10.032
15. Kalaiarasi P, Pugalendi K V, Antihyperglycemic effect of 18- beta glycyrrhetinic acid, aglycone of glycyrrhizin on streptozotocin diabetic rats, Europ J Pharm 2009; 1: 269- 73. https://doi.org/10.1016/j.ejphar.2008.12.057
16. Khare, C P, Encyclopaedia of Indian Medicinal Plants, Springer: New York, NY, USA, 2004; pp. 233–235.
17. Ashok S, The Herbs of India, Hi Scan Pvt. Ltd.: Gujrat, India, 2005; Volume 2: p. 566.
18. Damle M, Glycyrrhiza glabra (Liquorice)—A potent medicinal herb, Inter. J. Herb. Medicinal, 2014, 2, 132–136.
19. Kaur R, Dhinds A S, Glycyrrhiza glabra: A phytopharmacological review, IJPSR 2013, 4, 2470–2477.
20. Tewari D, Mocan A, Parvanov E D, Sah A N, Nabavi S M, Huminiecki L, Ma Z F, Lee Y Y, Horba nczuk J O, Atanasov A G, Ethnopharmacological approaches for therapy of jaundice: Part II, Highly used plant species from Acanthaceae, Euphorbiaceae, Asteraceae, Combretaceae, and Fabaceae families, Front. Pharm, 2017, 8, 519.
21. Zadeh J B, Kor Z M, Goftar M K, Licorice (Glycyrrhiza glabra Linn) as a valuable medicinal plant, Inter. J. Advance. Biol. Biomed. Res, 2013, 1: 1281–1288.
22. Biondi D M, Rocco C, Ruberto G, New dihydrostilbene derivatives from the leaves of Glycycrrhiza glabra and evaluation of their antioxidant activity, J. Nat. Prod, 2003, 66: 477–480.
23. Washington D C, Food Chemicals Codex, National Academy Press: USA, 2003; Volume 25.
24. Isbrucker R A, Burdock G A, Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.) its extract and powder as a food ingredient with emphasis on the pharmacology and toxicology of glycyrrhizin, Regul. Toxicol. Pharmacol, 2006, 4: 167–192.
25. Shah, S L, Wahid F, Khan N, Farooq U, Shah A J, Tareen S, Ahmad F, Khan T, Inhibitory effects of Glycyrrhiza glabra and its major constituent Glycyrrhizin on inflammation- associated corneal neovascularization, Evid. Based Complement Alternate Med, 2018, 8.
26. Rackova L, Jancinova V, Petrikova M, Drabikova K, Nosal R, Stefek M, Kovácová M, Mechanism of anti‐inflammatory action of liquorice extract and glycyrrhizin. Natural Product Research, 2007, 21(14), 1234–1241.
27. Biondi D M, Rocco C, Ruberto G, New dihydrostilbene derivatives from the leaves of Glycyrrhiza glabra and evaluation of their antioxidant activity. Journal of Natural Products, 2003; 66(4): 477–480.
28. Haraguchi H, Ishikawa H, Mizutani K, Tamura Y, Kinoshita T, Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorganic & Medicinal Chemistry, 1948; 6(3): 339–347.
29. Xuying W, Ming L, Xiao dong L, Ping H, Hepatoprotective and antihepatocarcinogenic effects of glycyrrhizin and matrine, J Chemico Biological Interac, 2009; 181(1): 15-19. https://doi.org/10.1016/j.cbi.2009.04.013
30. Sianne S, Fanie R V H, Antimalarial activity of plant metabolites, Nat Prod Rep, 2002; 19: 675-692. https://doi.org/10.3390/ijms19051382
31. Hojoa H, Satob J, Antifungal Activity of Licorice (Glycyrrhiza glabra) and potential applications in beverage foods Food Ingredients J Japan 2002; 203.
https://doi.org/10.1016/j.apsb.2015.05.005
32. Ju HS, Li X J, Zhao B L, Han Z W, Xin W, Effects of Glycyrrhiza Flavonoids on lipid peroxidation and active oxygen radicals, Acta Pharm Sinicia, 1989; 24(11): 807-812.
33. Krausse R, Bielenberg J, Blaschek W, Ullmann U. In anti- Helicobacter pylori activity of Extractum liquiritiae glycyrrhizin and its metabolites, J Antimicrob Chemother, 2004; 54(1): 243-246.
34. Ohuchi K, Tsurufuji A, A study of the anti-inflammatory mechanism of glycyrrhizin, Mino Med Rev, 1982; 27: 188- 193.
35. MendesSilva W, Assafim M, Ruta B, Monteiro R Q, Guimaraes J A, Zingali R B, Antithrombotic effect of Glycyrrhizin a plant-derived thrombin inhibitor, Thromb Res 2003; 112: 93-98.
https://doi.org/10.1016/j.thromres.2003.10.014.
36. Dhingra D, Sharma A, Antidepressant‐like activity of Glycyrrhiza glabra L. in mouse models of immobility tests, Progress in Neuro‐Psychopharmacology and Biological Psychiatry, 2006; 30(3): 449–454.
37. Chakravarthi K K, Avadhani R, Beneficial effect of aqueous root extract of Glycyrrhiza glabra on learning and memory using different behavioral models an experimental study, Journal of Natural Science, Biology and Medicine, 2013; 4(2): 420–425.
38. Yokota T, Nishio H, Kubota Y, Mizoguchi M, The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation, Pigment Cell Research, 1998; 11(6): 355–361.
39. Hasanein P, Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats, Acta Physiological Hungarica, 2011; 98(2): 221–230.
40. Plant encyclopaedia, Glycyrrhiza glabra (licorice / liquorice). http:// www. avogel. ch/en/plantencyclopaedia/glycyrrhiza_glabra.php.
41. The Plant list, A working list of all plant species, Glycyrrhiza glabra. http://www. theplantlist.org/tpl1.1/record/ild-7886
42. Pompei R, Pani A, Flore O, Marcialis M A, Loddo B, Antiviral activity of glycyrrhizic acid Experientia 1980; 36: 304. https://doi.org/10.1021/jm0493008
43. Kim Y W, Kang H E, Lee M G, Hwang S J, Kim S C, Lee C, Liquiritigenin a flavonoid aglycone from licorice has a choleretic effect and the ability to induce hepatic transporters and phase-II enzymes, Am J Physiol Gastrointest Liver Physiol, 2009; 296(2): 372-381. https://doi.org/10.1152/ajpgi.90524.2008.
44. Kuroda M, Mimaki Y, Sashida Y, Mae T, Kishida H, Nishiyama H, Tsukagawa M, Konishi E, Takahashi K, Kawada T, Nakagawa K, Kitahara M, Phenolics with PPAR–Ligand- binding activity obtained from Licorice (Glycyrrhiza uralensis roots) and ameliorative effects of Glycyrin on genetically diabetic KK-Ay mice, Bioorg Med Chem Lett, 2004; 55-61. https://doi.org/10.1016/j.bmcl.2003.09.052
45. Lee, C S, Kim Y J, Lee M S, Han E S, Lee S J, 18β‐ Glycyrrhetinic acid induces apoptotic cell death in SiHa cells and exhibits a synergistic effect against antibiotic anti‐ cancer drug toxicity. Life Sciences, 2008; 83(13–14): 481– 489.
46. Sharma, V, Agrawal R C, Shrivastava V K, Assessment of median lethal dose and anti‐mutagenic effects of Glycyrrhiza glabra root extract against chemically induced micronucleus formation in Swiss albino mice, International Journal of Basic & Clinical Pharmacology, 2014; 3(2): 292
47. Deng Q P, Wang M J, Zeng X, Chen G G, Huang R Y, Effects of glycyrrhizin in a mouse model of lung adenocarcinoma, Cellular Physiology and Biochemistry, International Journal of Experimental Cellular Physiology Biochemistry Pharmacology, 2017; 41(4): 1383–1392.
48. Roy S D, Karmakar P R, Dash S, Chakraborty J, Das B, Hair growth stimulating effect and phytochemical evaluation of hydro-alcoholic extract of Glycyrrhiza glabra, Global J Res Med PLants Indigen Med, 2014; 3(2): 40-47.
49. Cronin H, Draelos Z D, Top 10 botanical ingredients in 2010 anti-aging creams, J Cosm Derm, 2010; 9(3): 218-225. https://doi.org/10.1111/j.1473-2165.2010.00516.
50. Mills S Y, Bone K, Principles and Practice of Phytotherapy, Modern Herbal Medicine, Churchill Livingstone, London, 2000.
51. www.banlab.com/healingherbs/yashti madhu.htm [12/09/2009]
52. Trivedi R, Sharma K, Hydroalcoholic extract of Glycyrrhiza glabra attenuates chronic fatigue stress induced behavioral alterations in mice, International Journal of Pharmaceutical & Biological Sciences, 2011; 2: 996-1001.
53. Bhandage A, Shevkar K, Vaishali Undale V, Evaluation of antinociceptive activity of roots of Glycyrrhiza glabra, Journal of Pharmaceutical Research, 2009; 2: 803-7.
54. Ai-Razzuqii R A M, Al-Hussaini J A, Hepatoprotective effect of Glycyrrhiza glabra in CCl4 induced model in acute liver injury, Journal of Physiology & Pharmacology Advances, 2012; 2: 259-63.
55. Sowmya M, Kumar S, Antistress property of Glycyrrhiza glabra on stress induced Drosophila melanogaster, Journal of Stress Physiology & Biochemistry, 2010; 6: 18-27.
56. Sakr S, Shalaby S Y, Carbendazim induced testicular damage & oxidative stress in albino rats Ameliorative effect of liquorice aqueous extract, Toxicol Ind Health, 2012.
57. Rathi S G, Suthar M, Patel P, In vitro cytotoxic screening of Glycyrrhiza glabra, Pharmacology, 2009; 1: 239-43.
58. Rastogi R P, Mehrotra B N, Compendium Indian medicinal plants, CDRI Lucknow, National Institute of Science & information resources N D, 1990-94; 6: 395-98
59. Nitalikar M, Munde K C, Dhore B V, Studies of antibacterial activities of Glycyrrhiza glabra root extract, International Journal of Pharmaceutical Technology & Research, 2010; 2: 899-901.